STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRM96938.1Branched-chain amino acid aminotransferase. (347 aa)    
Predicted Functional Partners:
ilvD
Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family.
  
 0.983
KRM96193.1
2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 0.969
KRM96904.1
Homoserine dehydrogenase.
  
 
 0.933
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
  
 
 0.920
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 
 0.916
KRM96940.1
L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily.
    
 0.912
KRM96762.1
Transport protein.
  
 
 0.825
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
    
 0.821
ldh-2
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate.
    
 0.821
KRM97541.1
Bifunctional glutamate--cysteine ligase glutathione synthetase; Belongs to the glutamate--cysteine ligase type 1 family.
   
 
 0.819
Your Current Organism:
Lactobacillus aquaticus
NCBI taxonomy Id: 1423725
Other names: L. aquaticus DSM 21051, Lactobacillus aquaticus DSM 21051
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.