queH protein (Lactobacillus camelliae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

queH

Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (256 aa)

Predicted Functional Partners:

rnhB

0.889

queA

0.723

KRN25368.1

0.524

KRN25366.1

0.518

KRN18609.1

0.453

Your Current Organism:

Lactobacillus camelliae

NCBI taxonomy Id: 1423730
Other names: L. camelliae DSM 22697 = JCM 13995, Lactobacillus camelliae DSM 22697, Lactobacillus camelliae DSM 22697 = JCM 13995, Lactobacillus camelliae JCM 13995, Lactobacillus camelliae JCM 13995 = DSM 22697

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRN18609.1	queH	FC75_GL000549	FC75_GL000637	BadF BadG BcrA BcrD ATPase family protein.	Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).	0.453
KRN25366.1	queH	FC75_GL000636	FC75_GL000637	Hypothetical protein.	Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).	0.518
KRN25368.1	queH	FC75_GL000638	FC75_GL000637	Hypothetical protein.	Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).	0.524
queA	queH	FC75_GL001675	FC75_GL000637	S-adenosylmethionine tRNA-ribosyltransferase-isomerase (queuine synthetase); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).	Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).	0.723
queH	KRN18609.1	FC75_GL000637	FC75_GL000549	Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).	BadF BadG BcrA BcrD ATPase family protein.	0.453
queH	KRN25366.1	FC75_GL000637	FC75_GL000636	Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).	Hypothetical protein.	0.518
queH	KRN25368.1	FC75_GL000637	FC75_GL000638	Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).	Hypothetical protein.	0.524
queH	queA	FC75_GL000637	FC75_GL001675	Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).	S-adenosylmethionine tRNA-ribosyltransferase-isomerase (queuine synthetase); Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).	0.723
queH	rnhB	FC75_GL000637	FC75_GL002419	Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).	Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	0.889
rnhB	queH	FC75_GL002419	FC75_GL000637	Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.	Hypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).	0.889

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.889

expected number of edges:

19

PPI enrichment p-value:

0.0903

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046710

GDP metabolic process

3 of 7

2.86

2.26

7.37e-05

GO:0046037

GMP metabolic process

3 of 13

2.59

2.04

0.00017

GO:0046940

Nucleoside monophosphate phosphorylation

3 of 29

2.24

1.59

0.0010

GO:0010737

Protein kinase A signaling

2 of 9

2.58

1.31

0.0041

GO:0009150

Purine ribonucleotide metabolic process

4 of 242

1.45

1.07

0.0033

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004679

AMP-activated protein kinase activity

2 of 7

2.68

0.96

0.0185

GO:0004385

Guanylate kinase activity

2 of 6

2.75

0.96

0.0185

GO:0004691

cAMP-dependent protein kinase activity

2 of 8

2.63

0.95

0.0185

GO:0004115

3,5-cyclic-AMP phosphodiesterase activity

2 of 21

2.21

0.88

0.0238

GO:0016301

Kinase activity

5 of 625

1.13

0.68

0.0185

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005952

cAMP-dependent protein kinase complex

2 of 12

2.45

0.88

0.0253

GO:0030141

Secretory granule

2 of 15

2.35

0.87

0.0253

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15653

GDP metabolic process, and Dpy-30 motif

4 of 5

3.13

4.21

2.11e-08

CL:444

Mixed, incl. Atos-like, conserved domain, and Response to mechanical stimulus

2 of 6

2.75

1.48

0.0020

CL:3205

cAMP-dependent protein kinase complex, and Protein kinase, C-terminal

2 of 24

2.15

0.91

0.0200

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

6 of 223

1.66

2.52

2.06e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-418555

G alpha (s) signalling events

4 of 31

2.34

2.82

3.40e-06

MAP-111885

Opioid Signalling

4 of 49

2.14

2.51

9.45e-06

MAP-438064

Post NMDA receptor activation events

3 of 24

2.33

2.11

9.47e-05

MAP-111997

CaM pathway

3 of 25

2.31

2.11

9.47e-05

MAP-111933

Calmodulin induced events

3 of 25

2.31

2.11

9.47e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0002177

Manchette

2 of 4

2.93

1.24

0.0057

GOCC:0001669

Acrosomal vesicle

2 of 4

2.93

1.24

0.0057

GOCC:0005952

cAMP-dependent protein kinase complex

2 of 12

2.45

1.09

0.0099

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00471

Metal dependent phosphohydrolases with conserved HD motif.

2 of 26

2.11

0.78

0.0360

SM00015

Short calmodulin-binding motif containing conserved Ile and Gln residues.

2 of 20

2.23

0.78

0.0360

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Databases

Fusion

Textmining

Cooccurrence

Experiments

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About