KRM79590.1 protein (Lactobacillus dextrinicus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

KRM79590.1

Galactose operon transcriptional regulator, LacI family. (330 aa)

Predicted Functional Partners:

galK

0.926

galT

0.881

CcpA

0.791

GalE

0.779

KRM78342.1

0.768

KRM78742.1

0.764

KRM79951.1

0.750

KRM79816.1

0.662

KRM79922.1

0.585

Pyk

0.457

Your Current Organism:

Lactobacillus dextrinicus

NCBI taxonomy Id: 1423738
Other names: L. dextrinicus DSM 20335, Lactobacillus dextrinicus DSM 20335

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CcpA	KRM79590.1	FC84_GL000857	FC84_GL001058	CcpA transcriptional regulator (catabolic control protein A).	Galactose operon transcriptional regulator, LacI family.	0.791
CcpA	KRM79922.1	FC84_GL000857	FC84_GL000621	CcpA transcriptional regulator (catabolic control protein A).	ptsH protein.	0.828
CcpA	Pyk	FC84_GL000857	FC84_GL001339	CcpA transcriptional regulator (catabolic control protein A).	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.457
GalE	KRM79590.1	FC84_GL001057	FC84_GL001058	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	Galactose operon transcriptional regulator, LacI family.	0.779
GalE	KRM79816.1	FC84_GL001057	FC84_GL000513	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	Aldose 1-epimerase; Catalyzes the interconversion of alpha and beta anomers of maltose.	0.674
GalE	galK	FC84_GL001057	FC84_GL001056	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily.	0.997
GalE	galT	FC84_GL001057	FC84_GL001055	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	Galactose-1-phosphate uridylyltransferase.	0.999
KRM78342.1	KRM79590.1	FC84_GL001165	FC84_GL001058	LacI family sugar-binding transcriptional regulator.	Galactose operon transcriptional regulator, LacI family.	0.768
KRM78342.1	KRM79922.1	FC84_GL001165	FC84_GL000621	LacI family sugar-binding transcriptional regulator.	ptsH protein.	0.583
KRM78342.1	Pyk	FC84_GL001165	FC84_GL001339	LacI family sugar-binding transcriptional regulator.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.457
KRM78742.1	KRM79590.1	FC84_GL000369	FC84_GL001058	Bacterial regulatory s, lacI family protein.	Galactose operon transcriptional regulator, LacI family.	0.764
KRM78742.1	KRM79922.1	FC84_GL000369	FC84_GL000621	Bacterial regulatory s, lacI family protein.	ptsH protein.	0.585
KRM78742.1	Pyk	FC84_GL000369	FC84_GL001339	Bacterial regulatory s, lacI family protein.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.457
KRM79590.1	CcpA	FC84_GL001058	FC84_GL000857	Galactose operon transcriptional regulator, LacI family.	CcpA transcriptional regulator (catabolic control protein A).	0.791
KRM79590.1	GalE	FC84_GL001058	FC84_GL001057	Galactose operon transcriptional regulator, LacI family.	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	0.779
KRM79590.1	KRM78342.1	FC84_GL001058	FC84_GL001165	Galactose operon transcriptional regulator, LacI family.	LacI family sugar-binding transcriptional regulator.	0.768
KRM79590.1	KRM78742.1	FC84_GL001058	FC84_GL000369	Galactose operon transcriptional regulator, LacI family.	Bacterial regulatory s, lacI family protein.	0.764
KRM79590.1	KRM79816.1	FC84_GL001058	FC84_GL000513	Galactose operon transcriptional regulator, LacI family.	Aldose 1-epimerase; Catalyzes the interconversion of alpha and beta anomers of maltose.	0.662
KRM79590.1	KRM79922.1	FC84_GL001058	FC84_GL000621	Galactose operon transcriptional regulator, LacI family.	ptsH protein.	0.585
KRM79590.1	KRM79951.1	FC84_GL001058	FC84_GL000652	Galactose operon transcriptional regulator, LacI family.	Bacterial regulatory s, lacI family protein.	0.750

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.878

expected number of edges:

13

PPI enrichment p-value:

1.85e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0021577

Hindbrain structural organization

5 of 7

3.26

6.11

6.72e-12

GO:1903895

Negative regulation of IRE1-mediated unfolded protein response

5 of 10

3.11

5.92

1.27e-11

GO:0031204

Post-translational protein targeting to membrane, translocation

5 of 10

3.11

5.92

1.27e-11

GO:0006983

ER overload response

5 of 11

3.07

5.88

1.39e-11

GO:0035437

Maintenance of protein localization in endoplasmic reticulum

5 of 16

2.9

5.58

3.69e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140662

ATP-dependent protein folding chaperone

10 of 36

2.85

12.13

7.01e-25

GO:0044183

Protein folding chaperone

11 of 65

2.64

11.79

7.01e-26

GO:0051787

Misfolded protein binding

7 of 33

2.73

7.54

1.98e-15

GO:0043022

Ribosome binding

5 of 75

2.23

3.72

2.23e-08

GO:0031625

Ubiquitin protein ligase binding

6 of 212

1.86

3.16

2.42e-08

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034663

Endoplasmic reticulum chaperone complex

5 of 8

3.2

6.16

5.09e-12

GO:0005793

Endoplasmic reticulum-Golgi intermediate compartment

5 of 75

2.23

3.59

4.69e-08

GO:0042470

Melanosome

5 of 88

2.16

3.45

6.75e-08

GO:0005788

Endoplasmic reticulum lumen

5 of 89

2.16

3.44

6.75e-08

GO:0030176

Integral component of endoplasmic reticulum membrane

5 of 132

1.99

3.04

2.06e-07

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37761919

(2023) Hsp70 Gene Family in Sebastiscus marmoratus: The Genome-Wide Identification and Transcriptome Analysis under Thermal Stress.

4 of 10

3.01

3.94

6.01e-08

PMID:33150058

(2020) Genome-wide identification of Hsp70110 genes in rainbow trout and their regulated expression in response to heat stress.

3 of 9

2.93

2.61

1.74e-05

PMID:30501106

(2018) Genome-Wide Identification of Hsp70 Genes in the Large Yellow Croaker (Larimichthys crocea) and Their Regulated Expression Under Cold and Heat Stress.

3 of 8

2.98

2.61

1.74e-05

PMID:34880782

(2021) HSP90 and HSP70 Families in Lateolabrax maculatus: Genome-Wide Identification, Molecular Characterization, and Expression Profiles in Response to Various Environmental Stressors.

2 of 8

2.81

1.23

0.0060

PMID:30691127

(2019) The Hsp70 Gene Family in Boleophthalmus pectinirostris: Genome-Wide Identification and Expression Analysis under High Ammonia Stress.

2 of 7

2.86

1.23

0.0060

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10359

Protein folding, and Conjugation with cellular fusion

11 of 79

2.55

10.96

1.09e-24

CL:10366

Mixed, incl. Misfolded protein binding, and Chaperone DnaJ, C-terminal

9 of 59

2.59

9.25

5.66e-20

CL:10448

Mixed, incl. Endoplasmic reticulum chaperone complex, and Protein folding in endoplasmic reticulum

5 of 15

2.93

5.7

2.33e-11

CL:10370

Mixed, incl. Protein refolding, and DnaJ C terminal domain

4 of 34

2.48

3.33

4.10e-07

CL:10467

Hindbrain structural organization, and Calreticulin family

3 of 5

3.19

3.32

9.55e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

onl03060

Protein export

3 of 22

2.54

2.7

8.43e-06

onl04141

Protein processing in endoplasmic reticulum

5 of 179

1.85

2.65

8.39e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3371453

Regulation of HSF1-mediated heat shock response

11 of 98

2.46

10.35

2.90e-24

MAP-3371556

Cellular response to heat stress

11 of 157

2.25

8.67

2.04e-22

MAP-983170

Antigen Presentation: Folding, assembly and peptide loading of class I MHC

5 of 84

2.18

3.55

4.27e-08

MAP-2262752

Cellular responses to stress

11 of 878

1.51

3.19

1.63e-14

MAP-8953897

Cellular responses to stimuli

11 of 889

1.5

3.17

1.63e-14

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0067

ATP-binding

6 of 982

1.19

1.15

0.00024

KW-0175

Coiled coil

8 of 3711

0.74

0.6

0.0012

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06723

MreB/Mbl protein

8 of 15

3.13

10.5

1.96e-20

PF00012

Hsp70 protein

4 of 7

3.16

4.55

4.94e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029047

Heat shock protein 70kD, peptide-binding domain superfamily

7 of 10

3.25

9.12

1.41e-17

IPR013126

Heat shock protein 70 family

7 of 13

3.14

8.89

2.80e-17

IPR018181

Heat shock protein 70, conserved site

6 of 10

3.19

7.57

1.09e-14

IPR043129

ATPase, nucleotide binding domain

7 of 49

2.56

6.67

4.17e-14

IPR029048

Heat shock protein 70kD, C-terminal domain superfamily

5 of 9

3.15

6.05

7.64e-12

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About