KRL65001.1 protein (Lactobacillus diolivorans)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

KRL65001.1

Integral membrane protein. (259 aa)

Predicted Functional Partners:

KRL62900.1

0.727

KRL69508.1

0.462

KRL64444.1

0.462

KRL65002.1

0.452

KRL69998.1

0.425

Your Current Organism:

Lactobacillus diolivorans

NCBI taxonomy Id: 1423739
Other names: L. diolivorans DSM 14421, Lactobacillus diolivorans DSM 14421

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRL62900.1	KRL64444.1	FC85_GL001770	FC85_GL000954	Hypothetical protein.	PDZ DHR GLGF domain-containing protein.	0.462
KRL62900.1	KRL65001.1	FC85_GL001770	FC85_GL000797	Hypothetical protein.	Integral membrane protein.	0.727
KRL62900.1	KRL69508.1	FC85_GL001770	FC85_GL000388	Hypothetical protein.	Serine protease do-like protein.	0.462
KRL64444.1	KRL62900.1	FC85_GL000954	FC85_GL001770	PDZ DHR GLGF domain-containing protein.	Hypothetical protein.	0.462
KRL64444.1	KRL65001.1	FC85_GL000954	FC85_GL000797	PDZ DHR GLGF domain-containing protein.	Integral membrane protein.	0.462
KRL65001.1	KRL62900.1	FC85_GL000797	FC85_GL001770	Integral membrane protein.	Hypothetical protein.	0.727
KRL65001.1	KRL64444.1	FC85_GL000797	FC85_GL000954	Integral membrane protein.	PDZ DHR GLGF domain-containing protein.	0.462
KRL65001.1	KRL65002.1	FC85_GL000797	FC85_GL000798	Integral membrane protein.	MFS family major facilitator transporter.	0.452
KRL65001.1	KRL69508.1	FC85_GL000797	FC85_GL000388	Integral membrane protein.	Serine protease do-like protein.	0.462
KRL65001.1	KRL69998.1	FC85_GL000797	FC85_GL000028	Integral membrane protein.	Hypothetical protein.	0.425
KRL65002.1	KRL65001.1	FC85_GL000798	FC85_GL000797	MFS family major facilitator transporter.	Integral membrane protein.	0.452
KRL69508.1	KRL62900.1	FC85_GL000388	FC85_GL001770	Serine protease do-like protein.	Hypothetical protein.	0.462
KRL69508.1	KRL65001.1	FC85_GL000388	FC85_GL000797	Serine protease do-like protein.	Integral membrane protein.	0.462
KRL69998.1	KRL65001.1	FC85_GL000028	FC85_GL000797	Hypothetical protein.	Integral membrane protein.	0.425

Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.958

expected number of edges:

28

PPI enrichment p-value:

0.000288

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 362

1.8

4.85

1.50e-16

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

11 of 174

2.12

7.38

1.90e-20

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005761

Mitochondrial ribosome

9 of 82

2.36

7.78

3.79e-18

GO:0044391

Ribosomal subunit

10 of 151

2.14

6.98

1.54e-18

GO:0005840

Ribosome

11 of 204

2.05

6.89

4.88e-20

GO:0005762

Mitochondrial large ribosomal subunit

7 of 53

2.44

6.41

4.89e-14

GO:0098798

Mitochondrial protein-containing complex

9 of 274

1.83

4.52

5.76e-14

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4633

Organellar large ribosomal subunit, and Ribosomal protein L23

9 of 25

2.87

10.51

3.01e-21

CL:4635

Organellar large ribosomal subunit, and Ribosomal protein L23

8 of 20

2.92

9.73

1.95e-19

CL:4506

Mitochondrial translation elongation

10 of 95

2.34

8.41

3.61e-20

CL:4660

Mixed, incl. Ribosomal protein S12/S23, and Ribosomal protein L14p/L23e

5 of 7

3.17

6.19

4.34e-12

CL:4637

Ribosomal protein L23, and Organellar large ribosomal subunit

3 of 8

2.89

2.8

7.53e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lco03010

Ribosome

10 of 121

2.24

7.88

4.80e-20

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5389840

Mitochondrial translation elongation

9 of 93

2.3

7.21

4.37e-17

MAP-5419276

Mitochondrial translation termination

9 of 94

2.3

7.19

4.37e-17

MAP-5368287

Mitochondrial translation

9 of 100

2.27

7.1

4.37e-17

MAP-72766

Translation

10 of 337

1.79

4.59

2.54e-15

MAP-392499

Metabolism of proteins

10 of 2732

0.88

0.92

1.95e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

11 of 154

2.17

7.89

2.99e-21

GOCC:0005761

Mitochondrial ribosome

9 of 78

2.38

7.89

3.03e-18

GOCC:0044391

Ribosomal subunit

10 of 118

2.25

7.76

1.76e-19

GOCC:0005762

Mitochondrial large ribosomal subunit

7 of 47

2.49

6.7

1.81e-14

GOCC:0098798

Mitochondrial protein complex

9 of 228

1.91

4.96

1.63e-14

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

11 of 159

2.16

7.93

9.70e-22

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