KRL68605.1 protein (Lactobacillus diolivorans)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

KRL68605.1

Hypothetical protein. (801 aa)

Predicted Functional Partners:

KRL64904.1

0.565

KRL67439.1

0.499

KRL65049.1

0.490

KRL64905.1

0.487

KRL65761.1

0.470

KRL65119.1

0.438

KRL68604.1

0.433

KRL70170.1

0.425

KRL64494.1

0.423

KRL69327.1

0.412

Your Current Organism:

Lactobacillus diolivorans

NCBI taxonomy Id: 1423739
Other names: L. diolivorans DSM 14421, Lactobacillus diolivorans DSM 14421

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRL64494.1	KRL64904.1	FC85_GL001004	FC85_GL000692	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.	Hypothetical protein.	0.600
KRL64494.1	KRL64905.1	FC85_GL001004	FC85_GL000693	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.	Hypothetical protein.	0.687
KRL64494.1	KRL65049.1	FC85_GL001004	FC85_GL000542	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.	Hypothetical protein.	0.478
KRL64494.1	KRL65119.1	FC85_GL001004	FC85_GL000477	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.	Glycoside hydrolase family protein.	0.481
KRL64494.1	KRL65761.1	FC85_GL001004	FC85_GL003110	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.	Hypothetical protein.	0.718
KRL64494.1	KRL67439.1	FC85_GL001004	FC85_GL002683	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.	Glycosyl hydrolase family 25.	0.447
KRL64494.1	KRL68605.1	FC85_GL001004	FC85_GL002423	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.	Hypothetical protein.	0.423
KRL64494.1	KRL69327.1	FC85_GL001004	FC85_GL001493	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.	Hypothetical protein.	0.614
KRL64494.1	KRL70170.1	FC85_GL001004	FC85_GL003029	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.	Hypothetical protein.	0.551
KRL64904.1	KRL64494.1	FC85_GL000692	FC85_GL001004	Hypothetical protein.	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.	0.600
KRL64904.1	KRL64905.1	FC85_GL000692	FC85_GL000693	Hypothetical protein.	Hypothetical protein.	0.553
KRL64904.1	KRL65049.1	FC85_GL000692	FC85_GL000542	Hypothetical protein.	Hypothetical protein.	0.771
KRL64904.1	KRL65119.1	FC85_GL000692	FC85_GL000477	Hypothetical protein.	Glycoside hydrolase family protein.	0.769
KRL64904.1	KRL65761.1	FC85_GL000692	FC85_GL003110	Hypothetical protein.	Hypothetical protein.	0.773
KRL64904.1	KRL67439.1	FC85_GL000692	FC85_GL002683	Hypothetical protein.	Glycosyl hydrolase family 25.	0.722
KRL64904.1	KRL68605.1	FC85_GL000692	FC85_GL002423	Hypothetical protein.	Hypothetical protein.	0.565
KRL64904.1	KRL69327.1	FC85_GL000692	FC85_GL001493	Hypothetical protein.	Hypothetical protein.	0.773
KRL64904.1	KRL70170.1	FC85_GL000692	FC85_GL003029	Hypothetical protein.	Hypothetical protein.	0.768
KRL64905.1	KRL64494.1	FC85_GL000693	FC85_GL001004	Hypothetical protein.	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.	0.687
KRL64905.1	KRL64904.1	FC85_GL000693	FC85_GL000692	Hypothetical protein.	Hypothetical protein.	0.553

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.947

expected number of edges:

12

PPI enrichment p-value:

2.31e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044205

De novo UMP biosynthetic process

4 of 8

2.73

3.3

7.37e-07

GO:0006207

De novo pyrimidine nucleobase biosynthetic process

4 of 12

2.55

3.24

7.45e-07

GO:0042128

Nitrate assimilation

2 of 7

2.48

1.36

0.0032

GO:0044281

Small molecule metabolic process

7 of 1150

0.81

0.63

0.0024

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050464

Nitrate reductase (NADPH) activity

2 of 2

3.03

1.18

0.0076

GO:0004152

Dihydroorotate dehydrogenase activity

2 of 2

3.03

1.18

0.0076

GO:0004590

orotidine-5-phosphate decarboxylase activity

2 of 3

2.85

1.17

0.0076

GO:0043546

Molybdopterin cofactor binding

2 of 5

2.63

1.16

0.0076

GO:0030151

Molybdenum ion binding

2 of 9

2.38

1.15

0.0076

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10878

De novo UMP biosynthetic process, and Purine nucleobase transmembrane transporter activity

6 of 10

2.81

6.17

1.95e-12

CL:10881

De novo UMP biosynthetic process

3 of 5

2.81

2.86

5.50e-06

CL:10002

Molybdenum ion binding, and Prosthetic group metabolic process

3 of 15

2.33

2.17

7.36e-05

CL:10004

Oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor, and Nitronate monooxygenase

2 of 6

2.55

1.37

0.0031

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

plj00240

Pyrimidine metabolism

3 of 25

2.11

1.85

0.00024

plj00910

Nitrogen metabolism

2 of 16

2.13

1.13

0.0074

plj01100

Metabolic pathways

6 of 1076

0.77

0.55

0.0075

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-500753

Pyrimidine biosynthesis

4 of 7

2.79

3.71

1.30e-07

MAP-8956320

Nucleotide biosynthesis

4 of 23

2.27

2.78

3.43e-06

MAP-15869

Metabolism of nucleotides

4 of 80

1.73

1.65

0.00024

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01180

Dihydroorotate dehydrogenase

2 of 2

3.03

1.28

0.0050

PF03404

Mo-co oxidoreductase dimerisation domain

2 of 5

2.63

1.13

0.0087

PF00174

Oxidoreductase molybdopterin binding domain

2 of 5

2.63

1.13

0.0087

PF00970

Oxidoreductase FAD-binding domain

2 of 10

2.33

1.01

0.0137

PF00175

Oxidoreductase NAD-binding domain

2 of 18

2.07

0.81

0.0314

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036400

Cytochrome b5-like heme/steroid binding domain superfamily

3 of 21

2.18

1.3

0.0036

IPR001199

Cytochrome b5-like heme/steroid binding domain

3 of 21

2.18

1.3

0.0036

IPR005720

Dihydroorotate dehydrogenase domain

2 of 2

3.03

1.29

0.0047

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

2 of 5

2.63

1.05

0.0123

IPR008335

Eukaryotic molybdopterin oxidoreductase

2 of 5

2.63

1.05

0.0123

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

3 of 22

2.16

1.72

0.00048

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