KRL21303.1 protein (Lactobacillus gallinarum)

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Score

KRL21303.1

6-o-methylguanine dna methyltransferase, dna binding domain protein. (181 aa)

Predicted Functional Partners:

KRL21302.1

0.785

KRL21304.1

0.720

KRL21305.1

0.523

sigA

0.428

dinG

0.415

polA

0.403

Your Current Organism:

Lactobacillus gallinarum

NCBI taxonomy Id: 1423748
Other names: L. gallinarum DSM 10532 = JCM 2011, Lactobacillus gallinarum DSM 10532, Lactobacillus gallinarum DSM 10532 = JCM 2011, Lactobacillus gallinarum JCM 2011, Lactobacillus gallinarum JCM 2011 = DSM 10532

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRL21302.1	KRL21303.1	FC37_GL001387	FC37_GL001388	Tellurium resistance protein.	6-o-methylguanine dna methyltransferase, dna binding domain protein.	0.785
KRL21302.1	KRL21304.1	FC37_GL001387	FC37_GL001389	Tellurium resistance protein.	Nad-dependent deacetylase.	0.712
KRL21302.1	KRL21305.1	FC37_GL001387	FC37_GL001390	Tellurium resistance protein.	Conserved hypothetical membrane protein.	0.524
KRL21303.1	KRL21302.1	FC37_GL001388	FC37_GL001387	6-o-methylguanine dna methyltransferase, dna binding domain protein.	Tellurium resistance protein.	0.785
KRL21303.1	KRL21304.1	FC37_GL001388	FC37_GL001389	6-o-methylguanine dna methyltransferase, dna binding domain protein.	Nad-dependent deacetylase.	0.720
KRL21303.1	KRL21305.1	FC37_GL001388	FC37_GL001390	6-o-methylguanine dna methyltransferase, dna binding domain protein.	Conserved hypothetical membrane protein.	0.523
KRL21303.1	dinG	FC37_GL001388	FC37_GL001098	6-o-methylguanine dna methyltransferase, dna binding domain protein.	ATP-dependent DNA helicase DinG; 3'-5' exonuclease.	0.415
KRL21303.1	polA	FC37_GL001388	FC37_GL001234	6-o-methylguanine dna methyltransferase, dna binding domain protein.	DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.403
KRL21303.1	sigA	FC37_GL001388	FC37_GL001121	6-o-methylguanine dna methyltransferase, dna binding domain protein.	Rna polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	0.428
KRL21304.1	KRL21302.1	FC37_GL001389	FC37_GL001387	Nad-dependent deacetylase.	Tellurium resistance protein.	0.712
KRL21304.1	KRL21303.1	FC37_GL001389	FC37_GL001388	Nad-dependent deacetylase.	6-o-methylguanine dna methyltransferase, dna binding domain protein.	0.720
KRL21304.1	KRL21305.1	FC37_GL001389	FC37_GL001390	Nad-dependent deacetylase.	Conserved hypothetical membrane protein.	0.629
KRL21305.1	KRL21302.1	FC37_GL001390	FC37_GL001387	Conserved hypothetical membrane protein.	Tellurium resistance protein.	0.524
KRL21305.1	KRL21303.1	FC37_GL001390	FC37_GL001388	Conserved hypothetical membrane protein.	6-o-methylguanine dna methyltransferase, dna binding domain protein.	0.523
KRL21305.1	KRL21304.1	FC37_GL001390	FC37_GL001389	Conserved hypothetical membrane protein.	Nad-dependent deacetylase.	0.629
dinG	KRL21303.1	FC37_GL001098	FC37_GL001388	ATP-dependent DNA helicase DinG; 3'-5' exonuclease.	6-o-methylguanine dna methyltransferase, dna binding domain protein.	0.415
dinG	polA	FC37_GL001098	FC37_GL001234	ATP-dependent DNA helicase DinG; 3'-5' exonuclease.	DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	0.973
polA	KRL21303.1	FC37_GL001234	FC37_GL001388	DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	6-o-methylguanine dna methyltransferase, dna binding domain protein.	0.403
polA	dinG	FC37_GL001234	FC37_GL001098	DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	ATP-dependent DNA helicase DinG; 3'-5' exonuclease.	0.973
polA	sigA	FC37_GL001234	FC37_GL001121	DNA-directed DNA polymerase; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.	Rna polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	0.542

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Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.8

expected number of edges:

7

PPI enrichment p-value:

0.476

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045454

Cell redox homeostasis

3 of 9

2.06

1.21

0.0048

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016667

Oxidoreductase activity, acting on a sulfur group of donors

4 of 20

1.84

1.7

0.00027

GO:0016668

Oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor

3 of 9

2.06

1.47

0.0014

GO:0004148

Dihydrolipoyl dehydrogenase activity

2 of 2

2.54

1.15

0.0080

GO:0050660

Flavin adenine dinucleotide binding

3 of 37

1.45

0.76

0.0236

GO:0016491

Oxidoreductase activity

7 of 292

0.92

0.75

0.0014

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:701

Thioredoxin domain, and Cellular response to oxidative stress

5 of 11

2.2

3.25

2.41e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00380

Tryptophan metabolism

2 of 9

1.89

0.83

0.0254

map00310

Lysine degradation

2 of 9

1.89

0.83

0.0254

map00630

Glyoxylate and dicarboxylate metabolism

3 of 39

1.42

0.75

0.0239

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0676

Redox-active center

4 of 11

2.1

2.44

1.16e-05

KW-0274

FAD

3 of 25

1.62

1.11

0.0043

KW-0560

Oxidoreductase

6 of 166

1.1

1.01

0.00034

KW-0520

NAD

3 of 41

1.4

0.88

0.0103

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

3 of 4

2.41

1.86

0.00033

PF00578

AhpC/TSA family

3 of 8

2.11

1.61

0.00078

PF13738

Pyridine nucleotide-disulphide oxidoreductase

2 of 3

2.36

1.02

0.0135

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036249

Thioredoxin-like superfamily

5 of 27

1.81

2.12

1.97e-05

IPR013766

Thioredoxin domain

4 of 13

2.03

2.07

6.44e-05

IPR012999

Pyridine nucleotide-disulphide oxidoreductase, class I, active site

3 of 3

2.54

2.03

0.00017

IPR001100

Pyridine nucleotide-disulphide oxidoreductase, class I

3 of 3

2.54

2.03

0.00017

IPR016156

FAD/NAD-linked reductase, dimerisation domain superfamily

3 of 4

2.41

2.0

0.00018

(more ...)

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