KRM07140.1 protein (Lactobacillus ghanensis)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Score

KRM07140.1

Nitroreductase. (215 aa)

Predicted Functional Partners:

birA

0.581

KRM04729.1

0.562

KRM05564.1

0.490

KRM06043.1

0.463

KRM05703.1

0.462

KRM05705.1

0.462

menE

0.462

KRM07139.1

0.439

KRM06046.1

0.432

KRM05764.1

0.428

Your Current Organism:

Lactobacillus ghanensis

NCBI taxonomy Id: 1423750
Other names: L. ghanensis DSM 18630, Lactobacillus ghanensis DSM 18630

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRM04729.1	KRM07140.1	FC89_GL001975	FC89_GL000457	ABC transporter permease.	Nitroreductase.	0.562
KRM05564.1	KRM07140.1	FC89_GL001266	FC89_GL000457	Dioxygenase.	Nitroreductase.	0.490
KRM05564.1	birA	FC89_GL001266	FC89_GL001815	Dioxygenase.	Biotin operon repressor biotin--[acetyl-CoA-carboxylase] synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.	0.604
KRM05703.1	KRM05705.1	FC89_GL001410	FC89_GL001412	o-succinylbenzoate--CoA ligase.	acetyl-CoA synthetase.	0.585
KRM05703.1	KRM07140.1	FC89_GL001410	FC89_GL000457	o-succinylbenzoate--CoA ligase.	Nitroreductase.	0.462
KRM05705.1	KRM05703.1	FC89_GL001412	FC89_GL001410	acetyl-CoA synthetase.	o-succinylbenzoate--CoA ligase.	0.585
KRM05705.1	KRM07140.1	FC89_GL001412	FC89_GL000457	acetyl-CoA synthetase.	Nitroreductase.	0.462
KRM05764.1	KRM07140.1	FC89_GL001473	FC89_GL000457	Glutamate synthase large subunit.	Nitroreductase.	0.428
KRM06043.1	KRM06046.1	FC89_GL000910	FC89_GL000913	Hypothetical protein.	Transcription regulator.	0.813
KRM06043.1	KRM07140.1	FC89_GL000910	FC89_GL000457	Hypothetical protein.	Nitroreductase.	0.463
KRM06046.1	KRM06043.1	FC89_GL000913	FC89_GL000910	Transcription regulator.	Hypothetical protein.	0.813
KRM06046.1	KRM07140.1	FC89_GL000913	FC89_GL000457	Transcription regulator.	Nitroreductase.	0.432
KRM07139.1	KRM07140.1	FC89_GL000456	FC89_GL000457	Hypothetical protein.	Nitroreductase.	0.439
KRM07140.1	KRM04729.1	FC89_GL000457	FC89_GL001975	Nitroreductase.	ABC transporter permease.	0.562
KRM07140.1	KRM05564.1	FC89_GL000457	FC89_GL001266	Nitroreductase.	Dioxygenase.	0.490
KRM07140.1	KRM05703.1	FC89_GL000457	FC89_GL001410	Nitroreductase.	o-succinylbenzoate--CoA ligase.	0.462
KRM07140.1	KRM05705.1	FC89_GL000457	FC89_GL001412	Nitroreductase.	acetyl-CoA synthetase.	0.462
KRM07140.1	KRM05764.1	FC89_GL000457	FC89_GL001473	Nitroreductase.	Glutamate synthase large subunit.	0.428
KRM07140.1	KRM06043.1	FC89_GL000457	FC89_GL000910	Nitroreductase.	Hypothetical protein.	0.463
KRM07140.1	KRM06046.1	FC89_GL000457	FC89_GL000913	Nitroreductase.	Transcription regulator.	0.432

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

52

average node degree:

9.45

avg. local clustering coefficient:

0.958

expected number of edges:

20

PPI enrichment p-value:

2.86e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

6 of 62

1.51

1.91

6.21e-06

GO:0000160

Phosphorelay signal transduction system

5 of 52

1.51

1.66

5.65e-05

GO:0050794

Regulation of cellular process

9 of 253

1.08

1.24

2.38e-06

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

5 of 25

1.83

2.27

8.43e-06

GO:0000155

Phosphorelay sensor kinase activity

4 of 24

1.75

1.79

0.00011

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 171

1.14

1.22

2.82e-05

GO:0016740

Transferase activity

9 of 591

0.71

0.61

0.00028

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

7 of 579

0.61

0.36

0.0471

GO:0016021

Integral component of membrane

8 of 769

0.54

0.33

0.0471

GO:0016020

Membrane

9 of 1176

0.41

0.28

0.0471

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2148

Phosphorelay signal transduction system, and RNA polymerase sigma factor 54 interaction domain

11 of 41

1.96

6.07

1.09e-18

CL:2155

Mixed, incl. PAS domain, and Phosphoric diester hydrolase activity

8 of 21

2.11

5.5

6.46e-14

CL:2161

PAS-associated, C-terminal, and Bacterial chemotaxis

6 of 10

2.31

4.88

6.39e-11

CL:2163

Diguanylate cyclase, and Regulation of signaling

3 of 5

2.31

2.21

5.90e-05

CL:2215

Sigma-54 interaction domain, ATP-binding site 1, and PAS fold

3 of 7

2.16

2.01

0.00012

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

10 of 277

1.08

1.42

8.29e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

4 of 74

1.26

0.79

0.0122

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001610

PAC motif

4 of 8

2.23

2.3

3.24e-05

IPR035965

PAS domain superfamily

4 of 10

2.13

2.26

3.27e-05

IPR000014

PAS domain

4 of 10

2.13

2.26

3.27e-05

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

4 of 17

1.9

1.92

9.67e-05

IPR005467

Histidine kinase domain

4 of 20

1.83

1.81

0.00014

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

4 of 9

2.17

2.71

3.74e-06

SM00091

PAS domain

4 of 11

2.09

2.64

3.74e-06

SM00388

His Kinase A (phosphoacceptor) domain

4 of 17

1.9

2.31

1.03e-05

SM00387

Histidine kinase-like ATPases

4 of 22

1.79

2.1

1.92e-05

SM00065

Domain present in phytochromes and cGMP-specific phosphodiesterases.

2 of 5

2.13

1.25

0.0042

(more ...)

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