KRL93903.1 protein (Lactobacillus hammesii) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

KRL93903.1

Cell surface protein. (332 aa)

Predicted Functional Partners:

KRL93904.1

0.870

KRL93902.1

0.689

KRL97041.1

0.655

KRL94557.1

0.626

KRL93147.1

0.615

KRL97042.1

0.585

KRL93692.1

0.580

KRL94087.1

0.572

KRL93706.1

0.572

KRL95722.1

0.544

Your Current Organism:

Lactobacillus hammesii

NCBI taxonomy Id: 1423753
Other names: L. hammesii DSM 16381, Lactobacillus hammesii DSM 16381

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRL93147.1	KRL93903.1	FD28_GL001595	FD28_GL001094	Extracellular protein.	Cell surface protein.	0.615
KRL93147.1	KRL93904.1	FD28_GL001595	FD28_GL001095	Extracellular protein.	Hypothetical protein.	0.717
KRL93147.1	KRL97041.1	FD28_GL001595	FD28_GL001791	Extracellular protein.	Hypothetical protein.	0.597
KRL93692.1	KRL93903.1	FD28_GL000877	FD28_GL001094	Cell surface protein.	Cell surface protein.	0.580
KRL93692.1	KRL93904.1	FD28_GL000877	FD28_GL001095	Cell surface protein.	Hypothetical protein.	0.506
KRL93692.1	KRL97041.1	FD28_GL000877	FD28_GL001791	Cell surface protein.	Hypothetical protein.	0.755
KRL93692.1	KRL97042.1	FD28_GL000877	FD28_GL001792	Cell surface protein.	Hypothetical protein.	0.753
KRL93706.1	KRL93903.1	FD28_GL000891	FD28_GL001094	Hypothetical protein.	Cell surface protein.	0.572
KRL93706.1	KRL94557.1	FD28_GL000891	FD28_GL000379	Hypothetical protein.	Hypothetical protein.	0.504
KRL93706.1	KRL97041.1	FD28_GL000891	FD28_GL001791	Hypothetical protein.	Hypothetical protein.	0.436
KRL93706.1	KRL97042.1	FD28_GL000891	FD28_GL001792	Hypothetical protein.	Hypothetical protein.	0.651
KRL93902.1	KRL93903.1	FD28_GL001093	FD28_GL001094	Hypothetical protein.	Cell surface protein.	0.689
KRL93902.1	KRL93904.1	FD28_GL001093	FD28_GL001095	Hypothetical protein.	Hypothetical protein.	0.412
KRL93903.1	KRL93147.1	FD28_GL001094	FD28_GL001595	Cell surface protein.	Extracellular protein.	0.615
KRL93903.1	KRL93692.1	FD28_GL001094	FD28_GL000877	Cell surface protein.	Cell surface protein.	0.580
KRL93903.1	KRL93706.1	FD28_GL001094	FD28_GL000891	Cell surface protein.	Hypothetical protein.	0.572
KRL93903.1	KRL93902.1	FD28_GL001094	FD28_GL001093	Cell surface protein.	Hypothetical protein.	0.689
KRL93903.1	KRL93904.1	FD28_GL001094	FD28_GL001095	Cell surface protein.	Hypothetical protein.	0.870
KRL93903.1	KRL94087.1	FD28_GL001094	FD28_GL000634	Cell surface protein.	Hypothetical protein.	0.572
KRL93903.1	KRL94557.1	FD28_GL001094	FD28_GL000379	Cell surface protein.	Hypothetical protein.	0.626

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Network Stats

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Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045892

Negative regulation of transcription, DNA-templated

8 of 599

1.23

1.45

5.61e-06

GO:0051172

Negative regulation of nitrogen compound metabolic process

10 of 1220

1.01

1.12

2.62e-06

GO:0070544

Histone H3-K36 demethylation

2 of 7

2.56

1.12

0.0090

GO:0035518

Histone H2A monoubiquitination

2 of 8

2.5

1.09

0.0102

GO:0010605

Negative regulation of macromolecule metabolic process

10 of 1414

0.95

1.0

5.61e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140680

Histone H3-di/monomethyl-lysine-36 demethylase activity

2 of 3

2.92

1.18

0.0074

GO:0003682

Chromatin binding

5 of 314

1.3

0.89

0.0067

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031519

PcG protein complex

4 of 23

2.34

2.75

4.85e-06

GO:0035102

PRC1 complex

3 of 7

2.73

2.47

2.89e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1795

PcG protein complex, and RNA binding Region

8 of 20

2.7

8.24

4.74e-17

CL:1799

PcG protein complex

5 of 15

2.62

4.78

6.52e-10

CL:1802

RAWUL domain RING finger- and WD40-associated ubiquitin-like

3 of 5

2.88

2.81

7.19e-06

CL:18880

Alpha-macro-globulin thiol-ester bond-forming region, and Membrane attack complex

3 of 24

2.2

1.81

0.00034

CL:18918

Alpha-macro-globulin thiol-ester bond-forming region, and CUB domain

2 of 5

2.7

1.38

0.0031

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8939243

RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

5 of 27

2.37

3.76

3.60e-08

MAP-8943724

Regulation of PTEN gene transcription

5 of 40

2.2

3.39

1.09e-07

MAP-2559580

Oxidative Stress Induced Senescence

5 of 57

2.04

3.01

3.81e-07

MAP-6807070

PTEN Regulation

5 of 75

1.92

2.7

1.06e-06

MAP-3108214

SUMOylation of DNA damage response and repair proteins

4 of 41

2.09

2.52

7.47e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031519

PcG protein complex

3 of 20

2.28

1.6

0.00096

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF17208

RNA binding Region

2 of 2

3.1

1.23

0.0061

PF16207

RAWUL domain RING finger- and WD40-associated ubiquitin-like

2 of 4

2.8

1.17

0.0077

PF12140

SLED domain

2 of 5

2.7

1.16

0.0077

PF02008

CXXC zinc finger domain

2 of 5

2.7

1.16

0.0077

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00561

Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

2 of 9

2.45

0.9

0.0223

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