KRM37637.1 protein (Lactobacillus hamsteri) - STRING interaction network

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRM37637.1	KRM37638.1	FC39_GL000096	FC39_GL000097	Exopolyphosphatase.	Hypothetical protein.	0.637
KRM37637.1	KRM37640.1	FC39_GL000096	FC39_GL000099	Exopolyphosphatase.	Exopolyphosphatase.	0.994
KRM37637.1	KRM41214.1	FC39_GL000096	FC39_GL001225	Exopolyphosphatase.	GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.954
KRM37637.1	ppaC	FC39_GL000096	FC39_GL001017	Exopolyphosphatase.	Manganese-dependent inorganic pyrophosphatase.	0.437
KRM37637.1	ppk	FC39_GL000096	FC39_GL000098	Exopolyphosphatase.	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	0.978
KRM37638.1	KRM37637.1	FC39_GL000097	FC39_GL000096	Hypothetical protein.	Exopolyphosphatase.	0.637
KRM37638.1	KRM37640.1	FC39_GL000097	FC39_GL000099	Hypothetical protein.	Exopolyphosphatase.	0.905
KRM37638.1	ppk	FC39_GL000097	FC39_GL000098	Hypothetical protein.	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	0.835
KRM37640.1	KRM37637.1	FC39_GL000099	FC39_GL000096	Exopolyphosphatase.	Exopolyphosphatase.	0.994
KRM37640.1	KRM37638.1	FC39_GL000099	FC39_GL000097	Exopolyphosphatase.	Hypothetical protein.	0.905
KRM37640.1	KRM41214.1	FC39_GL000099	FC39_GL001225	Exopolyphosphatase.	GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	0.954
KRM37640.1	ppaC	FC39_GL000099	FC39_GL001017	Exopolyphosphatase.	Manganese-dependent inorganic pyrophosphatase.	0.437
KRM37640.1	ppk	FC39_GL000099	FC39_GL000098	Exopolyphosphatase.	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	0.977
KRM41214.1	KRM37637.1	FC39_GL001225	FC39_GL000096	GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	Exopolyphosphatase.	0.954
KRM41214.1	KRM37640.1	FC39_GL001225	FC39_GL000099	GTP diphosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.	Exopolyphosphatase.	0.954
ppaC	KRM37637.1	FC39_GL001017	FC39_GL000096	Manganese-dependent inorganic pyrophosphatase.	Exopolyphosphatase.	0.437
ppaC	KRM37640.1	FC39_GL001017	FC39_GL000099	Manganese-dependent inorganic pyrophosphatase.	Exopolyphosphatase.	0.437
ppk	KRM37637.1	FC39_GL000098	FC39_GL000096	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	Exopolyphosphatase.	0.978
ppk	KRM37638.1	FC39_GL000098	FC39_GL000097	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	Hypothetical protein.	0.835
ppk	KRM37640.1	FC39_GL000098	FC39_GL000099	Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family.	Exopolyphosphatase.	0.977

Network Stats

number of nodes:

number of edges:

average node degree:

2.86

avg. local clustering coefficient:

0.8

expected number of edges:

PPI enrichment p-value:

0.0929

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0021517

Ventral spinal cord development

5 of 46

2.29

3.26

3.39e-07

GO:0021510

Spinal cord development

6 of 99

2.04

3.17

1.40e-07

GO:0021522

Spinal cord motor neuron differentiation

4 of 30

2.38

2.79

4.21e-06

GO:0021520

Spinal cord motor neuron cell fate specification

3 of 9

2.78

2.55

2.02e-05

GO:0021953

Central nervous system neuron differentiation

6 of 175

1.79

2.53

1.04e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0001228

DNA-binding transcription activator activity, RNA polymerase II-specific

6 of 458

1.37

1.42

0.00011

GO:0030274

LIM domain binding

2 of 7

2.71

1.36

0.0033

GO:0140110

Transcription regulator activity

10 of 1931

0.97

1.03

4.15e-06

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

8 of 1368

1.02

0.99

0.00011

GO:1990837

Sequence-specific double-stranded DNA binding

8 of 1564

0.96

0.9

0.00015

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000785

Chromatin

9 of 1285

1.1

1.27

2.20e-06

GO:0005667

Transcription regulator complex

4 of 517

1.14

0.56

0.0469

GO:0043232

Intracellular non-membrane-bounded organelle

10 of 5191

0.54

0.39

0.0093

GO:0005634

Nucleus

11 of 7672

0.41

0.31

0.0129

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:30127719

(2018) Necessity and Sufficiency of Ldb1 in the Generation, Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.

8 of 52

2.44

5.61

3.75e-12

PMID:27939581

(2016) Expression of Terminal Effector Genes in Mammalian Neurons Is Maintained by a Dynamic Relay of Transient Enhancers.

7 of 29

2.64

5.44

3.02e-11

PMID:28139974

(2017) The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 alpha-enhancer activity.

7 of 31

2.61

5.41

3.05e-11

PMID:29694927

(2018) Transcription factor mechanisms guiding motor neuron differentiation and diversification.

7 of 34

2.57

5.31

4.07e-11

PMID:23193182

(2013) Islet alpha-, beta-, and delta-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor.

7 of 38

2.52

5.16

6.56e-11

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:20507

Mixed, incl. Neuron fate commitment, and Maturity onset diabetes of the young

9 of 83

2.29

6.95

1.76e-16

CL:20510

Mixed, incl. Neuron fate commitment, and Forebrain regionalization

8 of 57

2.4

6.91

1.68e-15

CL:20603

Mixed, incl. Sequence-specific single-strand DNA-binding protein, and Insulin gene enhancer protein ISL-1/2-like

5 of 10

2.95

5.58

4.26e-11

CL:20605

Insulin gene enhancer protein ISL-1/2-like, and Medial motor column neuron differentiation

4 of 5

3.16

4.58

4.32e-09

CL:20512

Mixed, incl. Telencephalon regionalization, and Cerebral cortex GABAergic interneuron differentiation

3 of 38

2.15

1.62

0.00078

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

hsa04950

Maturity onset diabetes of the young

3 of 25

2.33

2.03

0.00014

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

HSA-9010553

Regulation of expression of SLITs and ROBOs

4 of 169

1.63

1.12

0.0041

HSA-400511

Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)

2 of 12

2.47

1.0

0.0147

HSA-1266738

Developmental Biology

6 of 1108

0.99

0.68

0.0088

Disease-gene Associations (DISEASES)

disease

description

count in network

strength

signal

false discovery rate

DOID:7378

Pituitary hypoplasia

2 of 5

2.86

0.87

0.0273

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0371

Homeobox

6 of 236

1.66

2.34

9.50e-07

KW-0440

LIM domain

3 of 70

1.89

1.54

0.00076

KW-0238

DNA-binding

9 of 1971

0.91

0.92

1.57e-05

KW-0217

Developmental protein

6 of 971

1.04

0.91

0.00070

KW-0010

Activator

5 of 684

1.12

0.91

0.0017

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01803

LIM-domain binding protein

2 of 2

3.25

1.34

0.0039

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017970

Homeobox, conserved site

6 of 188

1.76

2.36

2.68e-06

IPR001356

Homeobox domain

6 of 239

1.65

2.12

5.46e-06

IPR009057

Homeobox-like domain superfamily

6 of 300

1.55

1.88

1.38e-05

IPR041363

LIM interaction domain

2 of 2

3.25

1.4

0.0030

IPR029005

LIM-domain binding protein/SEUSS

2 of 2

3.25

1.4

0.0030

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00389

Homeodomain

6 of 237

1.66

2.31

1.19e-06

SM00132

Zinc-binding domain present in Lin-11, Isl-1, Mec-3.

3 of 71

1.88

1.24

0.0034

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