KRM84387.1 protein (Lactobacillus hominis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

KRM84387.1

Hypothetical protein. (118 aa)

Predicted Functional Partners:

KRM84384.1

0.773

KRM84385.1

0.773

KRM84386.1

0.773

KRM84388.1

0.773

KRM84389.1

0.732

KRM84390.1

0.732

KRM84391.1

0.556

KRM84392.1

0.556

KRM84393.1

0.491

KRM84394.1

0.491

Your Current Organism:

Lactobacillus hominis

NCBI taxonomy Id: 1423758
Other names: L. hominis DSM 23910 = CRBIP 24.179, Lactobacillus hominis 61D, Lactobacillus hominis CRBIP 24.179, Lactobacillus hominis CRBIP 24.179 = DSM 23910, Lactobacillus hominis DSM 23910, Lactobacillus hominis DSM 23910 = CRBIP 24.179, Lactobacillus sp. 61D

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRM84384.1	KRM84385.1	FC41_GL000783	FC41_GL000784	Major tail protein.	Hypothetical protein.	0.773
KRM84384.1	KRM84386.1	FC41_GL000783	FC41_GL000785	Major tail protein.	Hypothetical protein.	0.773
KRM84384.1	KRM84387.1	FC41_GL000783	FC41_GL000786	Major tail protein.	Hypothetical protein.	0.773
KRM84384.1	KRM84388.1	FC41_GL000783	FC41_GL000787	Major tail protein.	Phage QLRG family, putative DNA packaging.	0.773
KRM84384.1	KRM84389.1	FC41_GL000783	FC41_GL000788	Major tail protein.	Major head protein.	0.732
KRM84384.1	KRM84390.1	FC41_GL000783	FC41_GL000789	Major tail protein.	ClpP-like protease; Belongs to the peptidase S14 family.	0.732
KRM84384.1	KRM84391.1	FC41_GL000783	FC41_GL000790	Major tail protein.	Phage portal protein, HK97 family.	0.556
KRM84384.1	KRM84392.1	FC41_GL000783	FC41_GL000791	Major tail protein.	Hypothetical protein.	0.556
KRM84384.1	KRM84393.1	FC41_GL000783	FC41_GL000792	Major tail protein.	Phage terminase, large subunit.	0.491
KRM84384.1	KRM84394.1	FC41_GL000783	FC41_GL000793	Major tail protein.	Phage terminase, small subunit, P27 family.	0.491
KRM84385.1	KRM84384.1	FC41_GL000784	FC41_GL000783	Hypothetical protein.	Major tail protein.	0.773
KRM84385.1	KRM84386.1	FC41_GL000784	FC41_GL000785	Hypothetical protein.	Hypothetical protein.	0.773
KRM84385.1	KRM84387.1	FC41_GL000784	FC41_GL000786	Hypothetical protein.	Hypothetical protein.	0.773
KRM84385.1	KRM84388.1	FC41_GL000784	FC41_GL000787	Hypothetical protein.	Phage QLRG family, putative DNA packaging.	0.773
KRM84385.1	KRM84389.1	FC41_GL000784	FC41_GL000788	Hypothetical protein.	Major head protein.	0.732
KRM84385.1	KRM84390.1	FC41_GL000784	FC41_GL000789	Hypothetical protein.	ClpP-like protease; Belongs to the peptidase S14 family.	0.732
KRM84385.1	KRM84391.1	FC41_GL000784	FC41_GL000790	Hypothetical protein.	Phage portal protein, HK97 family.	0.556
KRM84385.1	KRM84392.1	FC41_GL000784	FC41_GL000791	Hypothetical protein.	Hypothetical protein.	0.556
KRM84385.1	KRM84393.1	FC41_GL000784	FC41_GL000792	Hypothetical protein.	Phage terminase, large subunit.	0.491
KRM84385.1	KRM84394.1	FC41_GL000784	FC41_GL000793	Hypothetical protein.	Phage terminase, small subunit, P27 family.	0.491

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

43

average node degree:

7.82

avg. local clustering coefficient:

0.891

expected number of edges:

12

PPI enrichment p-value:

1.62e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006508

Proteolysis

5 of 176

1.33

1.22

0.00050

GO:0009987

Cellular process

11 of 3593

0.36

0.28

0.0221

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140359

ABC-type transporter activity

7 of 32

2.22

5.2

3.57e-12

GO:0042626

ATPase-coupled transmembrane transporter activity

8 of 58

2.02

4.83

1.28e-12

GO:0005524

ATP binding

8 of 550

1.04

1.15

4.65e-06

GO:0036094

Small molecule binding

9 of 819

0.92

0.96

4.10e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016020

Membrane

9 of 2221

0.49

0.31

0.0384

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8633

Serralysin-like metalloprotease, C-terminal, and Peptidase C39, bacteriocin processing

4 of 26

2.06

2.08

6.89e-05

CL:8637

RTX calcium-binding nonapeptide repeat (4 copies), and Peptidase C39 family

3 of 18

2.1

1.67

0.00058

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02010

ABC transporters

7 of 214

1.39

1.94

3.37e-07

map03070

Bacterial secretion system

3 of 51

1.65

1.2

0.0027

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1222449

Mtb iron assimilation by chelation

2 of 13

2.06

1.33

0.0028

MAP-1222499

Latent infection - Other responses of Mtb to phagocytosis

2 of 53

1.45

0.8

0.0194

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030256

Type I protein secretion system complex

5 of 6

2.8

5.16

1.94e-10

GOCC:0032991

Protein-containing complex

7 of 856

0.79

0.58

0.0043

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0067

ATP-binding

7 of 326

1.21

1.39

1.01e-05

KW-0596

Phosphopantetheine

2 of 19

1.9

0.85

0.0240

KW-0472

Membrane

7 of 1240

0.63

0.4

0.0240

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00664

ABC transporter transmembrane region

6 of 14

2.51

5.31

3.01e-11

PF03412

Peptidase C39 family

3 of 4

2.75

2.52

2.33e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039421

Type 1 protein exporter

6 of 15

2.48

5.03

1.03e-10

IPR036640

ABC transporter type 1, transmembrane domain superfamily

6 of 15

2.48

5.03

1.03e-10

IPR011527

ABC transporter type 1, transmembrane domain

6 of 15

2.48

5.03

1.03e-10

IPR017871

ABC transporter-like, conserved site

7 of 50

2.02

4.25

1.03e-10

IPR003439

ABC transporter-like, ATP-binding domain

7 of 58

1.96

4.04

1.57e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

6 of 117

1.59

2.27

6.09e-07

SM00100

Cyclic nucleotide-monophosphate binding domain

2 of 14

2.03

0.98

0.0142

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Textmining

Coexpression

Databases

Fusion

© STRING Consortium 2024

Credits

Access

Info

About