KRL06729.1 protein (Lactobacillus hordei) - STRING interaction network

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

KRL06729.1

HAD superfamily hydrolase. (270 aa)

Predicted Functional Partners:

KRL06728.1

0.605

KRL06727.1

0.601

KRL06725.1

0.448

KRL07449.1

0.417

pdhA

0.412

KRL06812.1

0.410

KRL06813.1

0.410

Your Current Organism:

Lactobacillus hordei

NCBI taxonomy Id: 1423759
Other names: L. hordei DSM 19519, Lactobacillus hordei DSM 19519

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRL06725.1	KRL06727.1	FC92_GL000425	FC92_GL000427	23S rRNA m(5)C methyltransferase.	N-6 adenine-specific DNA methylase YitW.	0.573
KRL06725.1	KRL06728.1	FC92_GL000425	FC92_GL000428	23S rRNA m(5)C methyltransferase.	S9 family serine peptidase.	0.538
KRL06725.1	KRL06729.1	FC92_GL000425	FC92_GL000429	23S rRNA m(5)C methyltransferase.	HAD superfamily hydrolase.	0.448
KRL06727.1	KRL06725.1	FC92_GL000427	FC92_GL000425	N-6 adenine-specific DNA methylase YitW.	23S rRNA m(5)C methyltransferase.	0.573
KRL06727.1	KRL06728.1	FC92_GL000427	FC92_GL000428	N-6 adenine-specific DNA methylase YitW.	S9 family serine peptidase.	0.752
KRL06727.1	KRL06729.1	FC92_GL000427	FC92_GL000429	N-6 adenine-specific DNA methylase YitW.	HAD superfamily hydrolase.	0.601
KRL06728.1	KRL06725.1	FC92_GL000428	FC92_GL000425	S9 family serine peptidase.	23S rRNA m(5)C methyltransferase.	0.538
KRL06728.1	KRL06727.1	FC92_GL000428	FC92_GL000427	S9 family serine peptidase.	N-6 adenine-specific DNA methylase YitW.	0.752
KRL06728.1	KRL06729.1	FC92_GL000428	FC92_GL000429	S9 family serine peptidase.	HAD superfamily hydrolase.	0.605
KRL06729.1	KRL06725.1	FC92_GL000429	FC92_GL000425	HAD superfamily hydrolase.	23S rRNA m(5)C methyltransferase.	0.448
KRL06729.1	KRL06727.1	FC92_GL000429	FC92_GL000427	HAD superfamily hydrolase.	N-6 adenine-specific DNA methylase YitW.	0.601
KRL06729.1	KRL06728.1	FC92_GL000429	FC92_GL000428	HAD superfamily hydrolase.	S9 family serine peptidase.	0.605
KRL06729.1	KRL06812.1	FC92_GL000429	FC92_GL000334	HAD superfamily hydrolase.	Pyruvate dehydrogenase E1 component beta subunit.	0.410
KRL06729.1	KRL06813.1	FC92_GL000429	FC92_GL000335	HAD superfamily hydrolase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.410
KRL06729.1	KRL07449.1	FC92_GL000429	FC92_GL001838	HAD superfamily hydrolase.	Hypothetical protein.	0.417
KRL06729.1	pdhA	FC92_GL000429	FC92_GL000333	HAD superfamily hydrolase.	Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).	0.412
KRL06812.1	KRL06729.1	FC92_GL000334	FC92_GL000429	Pyruvate dehydrogenase E1 component beta subunit.	HAD superfamily hydrolase.	0.410
KRL06812.1	KRL06813.1	FC92_GL000334	FC92_GL000335	Pyruvate dehydrogenase E1 component beta subunit.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.999
KRL06812.1	pdhA	FC92_GL000334	FC92_GL000333	Pyruvate dehydrogenase E1 component beta subunit.	Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).	0.999
KRL06813.1	KRL06729.1	FC92_GL000335	FC92_GL000429	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	HAD superfamily hydrolase.	0.410

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Network Stats

number of nodes:

2

number of edges:

1

average node degree:

1

avg. local clustering coefficient:

1

expected number of edges:

1

PPI enrichment p-value:

0.5

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070006

Metalloaminopeptidase activity

4 of 9

2.41

2.88

3.04e-06

GO:0030145

Manganese ion binding

3 of 9

2.29

2.03

0.00013

GO:0046914

Transition metal ion binding

5 of 110

1.42

1.46

0.00013

GO:0046872

Metal ion binding

8 of 627

0.87

0.8

0.00013

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005965

Protein farnesyltransferase complex

2 of 3

2.59

1.03

0.0132

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8231

Mixed, incl. Pyrimidine nucleotide-sugar transmembrane transport, and Macromolecule depalmitoylation

6 of 35

2.0

3.43

2.02e-08

CL:8236

Pyrimidine nucleotide-sugar transmembrane transport, and Aminopeptidase activity

5 of 21

2.14

3.34

1.05e-07

CL:6054

Terpenoid backbone biosynthesis, and Short chain dehydrogenase

4 of 22

2.02

2.37

1.31e-05

CL:8258

Pyrimidine nucleotide-sugar transmembrane transport, and Aminopeptidase P, N-terminal

3 of 10

2.24

1.96

0.00017

CL:8260

Nucleotide-sugar transporter, and Aminopeptidase P, N-terminal

2 of 5

2.37

1.18

0.0066

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00900

Terpenoid backbone biosynthesis

4 of 20

2.06

2.55

5.82e-06

map00260

Glycine, serine and threonine metabolism

4 of 20

2.06

2.55

5.82e-06

map01100

Metabolic pathways

8 of 959

0.68

0.55

0.0011

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005965

Protein farnesyltransferase complex

2 of 3

2.59

0.99

0.0156

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0464

Manganese

3 of 12

2.16

1.81

0.00031

KW-0031

Aminopeptidase

2 of 11

2.02

0.93

0.0172

KW-0479

Metal-binding

5 of 353

0.91

0.58

0.0172

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00557

Metallopeptidase family M24

4 of 10

2.37

2.81

3.81e-06

PF00432

Prenyltransferase and squalene oxidase repeat

2 of 3

2.59

1.08

0.0108

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029149

Creatinase/Aminopeptidase P/Spt16, N-terminal

4 of 5

2.67

3.13

1.48e-06

IPR036005

Creatinase/aminopeptidase-like

4 of 10

2.37

2.72

5.86e-06

IPR000994

Peptidase M24

4 of 10

2.37

2.72

5.86e-06

IPR007865

Aminopeptidase P, N-terminal

3 of 3

2.76

2.36

4.70e-05

IPR045089

Prenyltransferase subunit beta

2 of 3

2.59

1.03

0.0133

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01011

Aminopeptidase P, N-terminal domain

3 of 3

2.76

2.55

2.05e-05

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