KRM50711.1 protein (Lactobacillus kefiri) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

KRM50711.1

Type II secretion system protein E. (329 aa)

Predicted Functional Partners:

KRM50712.1

0.997

KRM50714.1

0.961

KRM50713.1

0.952

KRM49547.1

0.904

KRM52207.1

0.814

KRM53863.1

0.812

KRM50710.1

0.741

comEA

0.724

KRM53639.1

0.667

KRM50717.1

0.551

Your Current Organism:

Lactobacillus kefiri

NCBI taxonomy Id: 1423764
Other names: L. kefiri DSM 20587 = JCM 5818, Lactobacillus kefiri DSM 20587, Lactobacillus kefiri DSM 20587 = JCM 5818, Lactobacillus kefiri JCM 5818

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRM49547.1	KRM50711.1	FC95_GL000487	FC95_GL001875	Peptidase A24A domain-containing protein.	Type II secretion system protein E.	0.904
KRM49547.1	KRM50712.1	FC95_GL000487	FC95_GL001876	Peptidase A24A domain-containing protein.	Type II secretion system F domain-containing protein.	0.898
KRM49547.1	KRM50713.1	FC95_GL000487	FC95_GL001877	Peptidase A24A domain-containing protein.	Competence protein ComGC.	0.624
KRM49547.1	KRM50714.1	FC95_GL000487	FC95_GL001878	Peptidase A24A domain-containing protein.	Hypothetical protein.	0.668
KRM49547.1	KRM52207.1	FC95_GL000487	FC95_GL001403	Peptidase A24A domain-containing protein.	DNA internalization-related competence protein ComEC Rec2.	0.804
KRM49547.1	KRM53863.1	FC95_GL000487	FC95_GL000330	Peptidase A24A domain-containing protein.	Helicase domain-containing protein.	0.439
KRM49547.1	comEA	FC95_GL000487	FC95_GL001401	Peptidase A24A domain-containing protein.	Competence protein ComEA.	0.660
KRM50710.1	KRM50711.1	FC95_GL001874	FC95_GL001875	Hypothetical protein.	Type II secretion system protein E.	0.741
KRM50710.1	KRM50712.1	FC95_GL001874	FC95_GL001876	Hypothetical protein.	Type II secretion system F domain-containing protein.	0.686
KRM50710.1	KRM50713.1	FC95_GL001874	FC95_GL001877	Hypothetical protein.	Competence protein ComGC.	0.646
KRM50710.1	KRM50714.1	FC95_GL001874	FC95_GL001878	Hypothetical protein.	Hypothetical protein.	0.458
KRM50710.1	KRM50717.1	FC95_GL001874	FC95_GL001881	Hypothetical protein.	Adenine-specific DNA methylase.	0.491
KRM50710.1	KRM52207.1	FC95_GL001874	FC95_GL001403	Hypothetical protein.	DNA internalization-related competence protein ComEC Rec2.	0.443
KRM50711.1	KRM49547.1	FC95_GL001875	FC95_GL000487	Type II secretion system protein E.	Peptidase A24A domain-containing protein.	0.904
KRM50711.1	KRM50710.1	FC95_GL001875	FC95_GL001874	Type II secretion system protein E.	Hypothetical protein.	0.741
KRM50711.1	KRM50712.1	FC95_GL001875	FC95_GL001876	Type II secretion system protein E.	Type II secretion system F domain-containing protein.	0.997
KRM50711.1	KRM50713.1	FC95_GL001875	FC95_GL001877	Type II secretion system protein E.	Competence protein ComGC.	0.952
KRM50711.1	KRM50714.1	FC95_GL001875	FC95_GL001878	Type II secretion system protein E.	Hypothetical protein.	0.961
KRM50711.1	KRM50717.1	FC95_GL001875	FC95_GL001881	Type II secretion system protein E.	Adenine-specific DNA methylase.	0.551
KRM50711.1	KRM52207.1	FC95_GL001875	FC95_GL001403	Type II secretion system protein E.	DNA internalization-related competence protein ComEC Rec2.	0.814

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.739

expected number of edges:

12

PPI enrichment p-value:

8.67e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008360

Regulation of cell shape

6 of 118

1.96

2.95

2.83e-07

GO:0007163

Establishment or maintenance of cell polarity

6 of 162

1.82

2.59

8.96e-07

GO:0030865

Cortical cytoskeleton organization

4 of 51

2.14

2.36

1.99e-05

GO:0032956

Regulation of actin cytoskeleton organization

6 of 286

1.57

1.96

8.33e-06

GO:0030036

Actin cytoskeleton organization

7 of 487

1.41

1.76

5.20e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003924

GTPase activity

4 of 287

1.39

0.64

0.0437

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043296

Apical junction complex

4 of 115

1.79

1.52

0.00064

GO:0005911

Cell-cell junction

5 of 376

1.37

1.2

0.00088

GO:0005938

Cell cortex

4 of 238

1.48

1.08

0.0036

GO:0005923

Bicellular tight junction

3 of 96

1.74

1.05

0.0078

GO:0005856

Cytoskeleton

7 of 1958

0.8

0.56

0.0078

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14053

Mixed, incl. Small GTPase Rho, and RHOU GTPase cycle

3 of 65

1.91

0.81

0.0285

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

fca04530

Tight junction

7 of 146

1.93

3.97

1.66e-10

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2173791

TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

3 of 15

2.55

2.02

0.00018

MAP-416572

Sema4D induced cell migration and growth-cone collapse

2 of 9

2.6

1.31

0.0040

MAP-400685

Sema4D in semaphorin signaling

2 of 12

2.47

1.26

0.0049

MAP-9012999

RHO GTPase cycle

6 of 577

1.27

1.23

0.00024

MAP-416482

G alpha (12/13) signalling events

3 of 85

1.8

1.19

0.0040

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070161

Anchoring junction

5 of 306

1.46

1.29

0.00077

GOCC:0070160

Tight junction

3 of 56

1.98

1.24

0.0039

GOCC:0005911

Cell-cell junction

4 of 219

1.51

1.08

0.0039

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0342

GTP-binding

4 of 170

1.62

1.41

0.00073

KW-0547

Nucleotide-binding

5 of 961

0.97

0.59

0.0200

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003578

Small GTPase Rho

4 of 22

2.51

2.78

5.67e-06

IPR001806

Small GTPase

4 of 130

1.74

1.26

0.0024

IPR005225

Small GTP-binding protein domain

4 of 151

1.67

1.21

0.0028

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00174

Rho (Ras homology) subfamily of Ras-like small GTPases

4 of 20

2.55

3.34

4.66e-07

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Textmining

Cooccurrence

Databases

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About