STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (216 aa)    
Predicted Functional Partners:
tdk
Thymidine kinase.
 
 
 0.971
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.969
recR
Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
    
 0.955
KRK79810.1
DNA polymerase III subunit delta.
 
  
 0.952
KRK79787.1
deoxyUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
  
 
 0.951
KRK81102.1
Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.937
KRK81101.1
Ribonucleotide-diphosphate reductase subunit beta.
  
 
 0.930
KRK79098.1
Haloacid dehalogenase family hydrolase.
   
  0.903
KRK79811.1
Hypothetical protein; Involved in initiation control of chromosome replication. Belongs to the YabA family.
  
    0.896
KRK79809.1
Aminotransferase class iv.
 
    0.893
Your Current Organism:
Lactobacillus nodensis
NCBI taxonomy Id: 1423775
Other names: L. nodensis DSM 19682 = JCM 14932 = NBRC 107160, Lactobacillus nodensis DSM 19682, Lactobacillus nodensis DSM 19682 = JCM 14932 = NBRC 107160, Lactobacillus nodensis JCM 14932, Lactobacillus nodensis NBRC 107160
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