metN protein (Lactobacillus oeni) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

metN

ABC transporter ATP-binding component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (357 aa)

Predicted Functional Partners:

KRL05943.1

0.999

KRL05945.1

0.999

KRL05789.1

0.998

KRL04554.1

0.913

KRL05252.1

0.899

KRL05999.1

0.898

KRL05652.1

0.885

KRL05106.1

0.879

KRL05738.1

0.847

KRL05792.1

0.770

Your Current Organism:

Lactobacillus oeni

NCBI taxonomy Id: 1423777
Other names: L. oeni DSM 19972, Lactobacillus oeni DSM 19972

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRL04554.1	metN	FD46_GL001685	FD46_GL000709	Oligopeptide ABC transporter.	ABC transporter ATP-binding component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.	0.913
KRL05106.1	metN	FD46_GL001051	FD46_GL000709	Branched-chain amino acid ABC transporter, permease protein; Belongs to the binding-protein-dependent transport system permease family.	ABC transporter ATP-binding component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.	0.879
KRL05252.1	metN	FD46_GL000962	FD46_GL000709	ABC transporter.	ABC transporter ATP-binding component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.	0.899
KRL05652.1	metN	FD46_GL000397	FD46_GL000709	Peptide nickel transport system permease protein.	ABC transporter ATP-binding component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.	0.885
KRL05738.1	metN	FD46_GL000489	FD46_GL000709	ABC transporter transmembrane protein.	ABC transporter ATP-binding component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.	0.847
KRL05789.1	KRL05943.1	FD46_GL000545	FD46_GL000708	Hypothetical protein.	D-methionine ABC transporter binding protein; Belongs to the nlpA lipoprotein family.	0.897
KRL05789.1	KRL05945.1	FD46_GL000545	FD46_GL000710	Hypothetical protein.	ABC-type metal ion transport system, permease component.	0.999
KRL05789.1	metN	FD46_GL000545	FD46_GL000709	Hypothetical protein.	ABC transporter ATP-binding component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.	0.998
KRL05792.1	KRL05945.1	FD46_GL000548	FD46_GL000710	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	ABC-type metal ion transport system, permease component.	0.465
KRL05792.1	metN	FD46_GL000548	FD46_GL000709	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	ABC transporter ATP-binding component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.	0.770
KRL05943.1	KRL05789.1	FD46_GL000708	FD46_GL000545	D-methionine ABC transporter binding protein; Belongs to the nlpA lipoprotein family.	Hypothetical protein.	0.897
KRL05943.1	KRL05945.1	FD46_GL000708	FD46_GL000710	D-methionine ABC transporter binding protein; Belongs to the nlpA lipoprotein family.	ABC-type metal ion transport system, permease component.	0.999
KRL05943.1	metN	FD46_GL000708	FD46_GL000709	D-methionine ABC transporter binding protein; Belongs to the nlpA lipoprotein family.	ABC transporter ATP-binding component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.	0.999
KRL05945.1	KRL05789.1	FD46_GL000710	FD46_GL000545	ABC-type metal ion transport system, permease component.	Hypothetical protein.	0.999
KRL05945.1	KRL05792.1	FD46_GL000710	FD46_GL000548	ABC-type metal ion transport system, permease component.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.465
KRL05945.1	KRL05943.1	FD46_GL000710	FD46_GL000708	ABC-type metal ion transport system, permease component.	D-methionine ABC transporter binding protein; Belongs to the nlpA lipoprotein family.	0.999
KRL05945.1	metN	FD46_GL000710	FD46_GL000709	ABC-type metal ion transport system, permease component.	ABC transporter ATP-binding component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.	0.999
KRL05999.1	metN	FD46_GL000331	FD46_GL000709	Multidrug protein lipid ABC transporter family ATP-binding and permease.	ABC transporter ATP-binding component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.	0.898
metN	KRL04554.1	FD46_GL000709	FD46_GL001685	ABC transporter ATP-binding component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.	Oligopeptide ABC transporter.	0.913
metN	KRL05106.1	FD46_GL000709	FD46_GL001051	ABC transporter ATP-binding component; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.	Branched-chain amino acid ABC transporter, permease protein; Belongs to the binding-protein-dependent transport system permease family.	0.879

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Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.884

expected number of edges:

13

PPI enrichment p-value:

0.035

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 114

1.48

3.0

1.12e-13

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 53

1.77

4.37

1.47e-14

GO:0019843

rRNA binding

4 of 42

1.47

1.16

0.0020

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 60

1.72

4.16

8.83e-15

GO:0015935

Small ribosomal subunit

2 of 8

1.89

1.08

0.0078

GO:0005622

Intracellular anatomical structure

11 of 1255

0.44

0.38

0.00035

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:901

Structural constituent of ribosome

10 of 57

1.74

4.17

3.15e-14

CL:980

Structural constituent of ribosome

4 of 10

2.1

2.74

2.34e-06

CL:902

rRNA-binding, and RNA polymerase

6 of 38

1.69

2.72

6.37e-08

CL:903

rRNA-binding, and Protein transport by the Sec complex

5 of 31

1.7

2.33

1.84e-06

CL:905

rRNA-binding

3 of 26

1.56

1.14

0.0032

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 58

1.73

4.26

5.36e-15

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

8 of 52

1.68

3.25

2.20e-10

GOCC:0043232

Intracellular non-membrane-bounded organelle

9 of 147

1.28

1.92

4.29e-09

GOCC:0022626

Cytosolic ribosome

3 of 22

1.63

1.22

0.0024

GOCC:0043229

Intracellular organelle

10 of 324

0.98

1.17

4.30e-08

GOCC:0044391

Ribosomal subunit

3 of 27

1.54

1.11

0.0036

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 62

1.7

4.05

1.91e-14

KW-0699

rRNA-binding

4 of 39

1.51

1.39

0.00046

KW-0820

tRNA-binding

2 of 12

1.72

0.74

0.0352

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