node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KRL04160.1 | glyA | FD46_GL001277 | FD46_GL001133 | Sua5 YciO YrdC YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.892 |
KRL04160.1 | prfA | FD46_GL001277 | FD46_GL001275 | Sua5 YciO YrdC YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.845 |
KRL04160.1 | upp | FD46_GL001277 | FD46_GL001278 | Sua5 YciO YrdC YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.747 |
KRL04470.1 | glyA | FD46_GL001600 | FD46_GL001133 | Sugar-phosphate isomerase, RpiB LacA LacB family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.948 |
KRL04470.1 | guaA | FD46_GL001600 | FD46_GL000390 | Sugar-phosphate isomerase, RpiB LacA LacB family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.535 |
KRL04470.1 | udk | FD46_GL001600 | FD46_GL001356 | Sugar-phosphate isomerase, RpiB LacA LacB family. | Uridine kinase. | 0.451 |
KRL04470.1 | upp | FD46_GL001600 | FD46_GL001278 | Sugar-phosphate isomerase, RpiB LacA LacB family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.915 |
KRL04490.1 | guaA | FD46_GL001620 | FD46_GL000390 | Cytosine deaminase. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.456 |
KRL04490.1 | pyrR | FD46_GL001620 | FD46_GL001733 | Cytosine deaminase. | Bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.950 |
KRL04490.1 | upp | FD46_GL001620 | FD46_GL001278 | Cytosine deaminase. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.965 |
glyA | KRL04160.1 | FD46_GL001133 | FD46_GL001277 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Sua5 YciO YrdC YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.892 |
glyA | KRL04470.1 | FD46_GL001133 | FD46_GL001600 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Sugar-phosphate isomerase, RpiB LacA LacB family. | 0.948 |
glyA | guaA | FD46_GL001133 | FD46_GL000390 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.820 |
glyA | prfA | FD46_GL001133 | FD46_GL001275 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. | 0.572 |
glyA | pyrH | FD46_GL001133 | FD46_GL001393 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.442 |
glyA | upp | FD46_GL001133 | FD46_GL001278 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.877 |
guaA | KRL04470.1 | FD46_GL000390 | FD46_GL001600 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Sugar-phosphate isomerase, RpiB LacA LacB family. | 0.535 |
guaA | KRL04490.1 | FD46_GL000390 | FD46_GL001620 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Cytosine deaminase. | 0.456 |
guaA | glyA | FD46_GL000390 | FD46_GL001133 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.820 |
guaA | pyrF | FD46_GL000390 | FD46_GL001726 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Orotidine 5-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.727 |