node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KRL08601.1 | KRL09496.1 | FD05_GL001766 | FD05_GL001598 | ComE operon protein 2. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.957 |
KRL08601.1 | tdk | FD05_GL001766 | FD05_GL001061 | ComE operon protein 2. | Thymidine kinase. | 0.949 |
KRL08601.1 | thyA | FD05_GL001766 | FD05_GL001255 | ComE operon protein 2. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.952 |
KRL08601.1 | tmk | FD05_GL001766 | FD05_GL001567 | ComE operon protein 2. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.948 |
KRL09464.1 | KRL09469.1 | FD05_GL001565 | FD05_GL001570 | DNA polymerase III subunit delta. | Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | 0.942 |
KRL09464.1 | recR | FD05_GL001565 | FD05_GL001569 | DNA polymerase III subunit delta. | Recombination protein recR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.945 |
KRL09464.1 | rsmI | FD05_GL001565 | FD05_GL001563 | DNA polymerase III subunit delta. | Ribosomal RNA small subunit methyltransferase I; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. | 0.918 |
KRL09464.1 | tmk | FD05_GL001565 | FD05_GL001567 | DNA polymerase III subunit delta. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.958 |
KRL09469.1 | KRL09464.1 | FD05_GL001570 | FD05_GL001565 | Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | DNA polymerase III subunit delta. | 0.942 |
KRL09469.1 | recR | FD05_GL001570 | FD05_GL001569 | Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | Recombination protein recR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.997 |
KRL09469.1 | rsmI | FD05_GL001570 | FD05_GL001563 | Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | Ribosomal RNA small subunit methyltransferase I; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. | 0.825 |
KRL09469.1 | tmk | FD05_GL001570 | FD05_GL001567 | Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.922 |
KRL09474.1 | KRL09475.1 | FD05_GL001575 | FD05_GL001576 | Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Ribonucleoside-diphosphate reductase. | 0.999 |
KRL09474.1 | KRL09496.1 | FD05_GL001575 | FD05_GL001598 | Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.753 |
KRL09474.1 | thyA | FD05_GL001575 | FD05_GL001255 | Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.636 |
KRL09474.1 | tmk | FD05_GL001575 | FD05_GL001567 | Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.952 |
KRL09475.1 | KRL09474.1 | FD05_GL001576 | FD05_GL001575 | Ribonucleoside-diphosphate reductase. | Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.999 |
KRL09475.1 | KRL09496.1 | FD05_GL001576 | FD05_GL001598 | Ribonucleoside-diphosphate reductase. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.459 |
KRL09475.1 | tmk | FD05_GL001576 | FD05_GL001567 | Ribonucleoside-diphosphate reductase. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.951 |
KRL09496.1 | KRL08601.1 | FD05_GL001598 | FD05_GL001766 | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | ComE operon protein 2. | 0.957 |