KRL11462.1 protein (Lactobacillus otakiensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

KRL11462.1

Hypothetical protein. (244 aa)

Predicted Functional Partners:

KRL11463.1

0.815

KRL09003.1

0.639

KRL08607.1

0.639

KRL10300.1

0.601

KRL09265.1

0.587

KRL11464.1

0.567

KRL09868.1

0.544

KRL09669.1

0.448

KRL11558.1

0.443

KRL09075.1

0.420

Your Current Organism:

Lactobacillus otakiensis

NCBI taxonomy Id: 1423780
Other names: L. otakiensis DSM 19908 = JCM 15040, Lactobacillus otakiensis DSM 19908, Lactobacillus otakiensis DSM 19908 = JCM 15040, Lactobacillus otakiensis JCM 15040, Lactobacillus otakiensis JCM 15040 = DSM 19908

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRL08607.1	KRL09003.1	FD05_GL001772	FD05_GL001095	Hypothetical protein.	Helix-turn-helix domain-containing protein.	0.661
KRL08607.1	KRL09669.1	FD05_GL001772	FD05_GL000649	Hypothetical protein.	Hypothetical protein.	0.511
KRL08607.1	KRL11462.1	FD05_GL001772	FD05_GL002095	Hypothetical protein.	Hypothetical protein.	0.639
KRL09003.1	KRL08607.1	FD05_GL001095	FD05_GL001772	Helix-turn-helix domain-containing protein.	Hypothetical protein.	0.661
KRL09003.1	KRL09669.1	FD05_GL001095	FD05_GL000649	Helix-turn-helix domain-containing protein.	Hypothetical protein.	0.489
KRL09003.1	KRL09868.1	FD05_GL001095	FD05_GL000853	Helix-turn-helix domain-containing protein.	Hypothetical protein.	0.458
KRL09003.1	KRL10300.1	FD05_GL001095	FD05_GL000424	Helix-turn-helix domain-containing protein.	Hypothetical protein.	0.453
KRL09003.1	KRL11462.1	FD05_GL001095	FD05_GL002095	Helix-turn-helix domain-containing protein.	Hypothetical protein.	0.639
KRL09075.1	KRL10300.1	FD05_GL001167	FD05_GL000424	Hypothetical protein.	Hypothetical protein.	0.437
KRL09075.1	KRL11462.1	FD05_GL001167	FD05_GL002095	Hypothetical protein.	Hypothetical protein.	0.420
KRL09265.1	KRL10300.1	FD05_GL001360	FD05_GL000424	dUTPase.	Hypothetical protein.	0.576
KRL09265.1	KRL11462.1	FD05_GL001360	FD05_GL002095	dUTPase.	Hypothetical protein.	0.587
KRL09669.1	KRL08607.1	FD05_GL000649	FD05_GL001772	Hypothetical protein.	Hypothetical protein.	0.511
KRL09669.1	KRL09003.1	FD05_GL000649	FD05_GL001095	Hypothetical protein.	Helix-turn-helix domain-containing protein.	0.489
KRL09669.1	KRL09868.1	FD05_GL000649	FD05_GL000853	Hypothetical protein.	Hypothetical protein.	0.435
KRL09669.1	KRL10300.1	FD05_GL000649	FD05_GL000424	Hypothetical protein.	Hypothetical protein.	0.534
KRL09669.1	KRL11462.1	FD05_GL000649	FD05_GL002095	Hypothetical protein.	Hypothetical protein.	0.448
KRL09669.1	KRL11558.1	FD05_GL000649	FD05_GL002195	Hypothetical protein.	Hypothetical protein.	0.436
KRL09868.1	KRL09003.1	FD05_GL000853	FD05_GL001095	Hypothetical protein.	Helix-turn-helix domain-containing protein.	0.458
KRL09868.1	KRL09669.1	FD05_GL000853	FD05_GL000649	Hypothetical protein.	Hypothetical protein.	0.435

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.915

expected number of edges:

10

PPI enrichment p-value:

2.83e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051382

Kinetochore assembly

3 of 12

2.72

1.93

0.00029

GO:0007059

Chromosome segregation

5 of 220

1.68

1.59

0.00029

GO:0000712

Resolution of meiotic recombination intermediates

2 of 17

2.4

0.87

0.0257

GO:0036297

Interstrand cross-link repair

2 of 25

2.23

0.81

0.0327

GO:0031297

Replication fork processing

2 of 29

2.16

0.78

0.0359

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0080122

AMP transmembrane transporter activity

2 of 4

3.02

1.16

0.0082

GO:0015228

Coenzyme A transmembrane transporter activity

2 of 4

3.02

1.16

0.0082

GO:0043262

Adenosine-diphosphatase activity

2 of 7

2.78

1.15

0.0082

GO:0015217

ADP transmembrane transporter activity

2 of 9

2.67

1.15

0.0082

GO:0005347

ATP transmembrane transporter activity

2 of 16

2.42

1.01

0.0140

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000775

Chromosome, centromeric region

5 of 150

1.85

2.32

7.01e-06

GO:0071821

FANCM-MHF complex

2 of 5

2.93

1.58

0.0014

GO:0043240

Fanconi anaemia nuclear complex

2 of 9

2.67

1.4

0.0028

GO:0000776

Kinetochore

3 of 101

1.8

1.24

0.0030

GO:0005694

Chromosome

6 of 900

1.15

1.03

0.00057

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4083

Centromere complex assembly, and AMP transport

7 of 16

2.97

8.07

5.63e-16

CL:4087

Centromere complex assembly, and Inner kinetochore

6 of 11

3.06

7.34

2.20e-14

CL:4090

Centromere complex assembly, and Inner kinetochore

3 of 6

3.02

3.0

3.36e-06

CL:2471

Fanconi anaemia nuclear complex, and CENP-S protein

2 of 12

2.55

1.13

0.0085

CL:2198

DNA replication, and Fanconi anemia pathway

3 of 165

1.58

0.8

0.0229

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

sdu03460

Fanconi anemia pathway

2 of 46

1.96

0.76

0.0376

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-774815

Nucleosome assembly

5 of 62

2.23

3.39

1.30e-07

MAP-606279

Deposition of new CENPA-containing nucleosomes at the centromere

5 of 62

2.23

3.39

1.30e-07

MAP-73886

Chromosome Maintenance

5 of 129

1.91

2.64

1.47e-06

MAP-499943

Interconversion of nucleotide di- and triphosphates

3 of 43

2.17

1.72

0.00049

MAP-141444

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal

3 of 108

1.77

1.11

0.0057

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0071821

FANCM-MHF complex

2 of 5

2.93

1.44

0.0025

GOCC:0000779

Condensed chromosome, centromeric region

3 of 48

2.12

1.36

0.0025

GOCC:0000776

Kinetochore

3 of 54

2.07

1.35

0.0025

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