KRL86923.1 protein (Lactobacillus pantheris)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

KRL86923.1

ABC superfamily ATP binding cassette transporter, ABC protein. (568 aa)

Predicted Functional Partners:

KRL86924.1

0.998

ecfT

0.981

KRL86922.1

0.979

KRL88197.1

0.948

KRL88195.1

0.772

KRL88118.1

0.740

KRL86765.1

0.740

ecfA-2

0.725

KRL88120.1

0.724

KRL86763.1

0.724

Your Current Organism:

Lactobacillus pantheris

NCBI taxonomy Id: 1423783
Other names: L. pantheris DSM 15945 = JCM 12539 = NBRC 106106, Lactobacillus pantheris DSM 15945, Lactobacillus pantheris DSM 15945 = JCM 12539 = NBRC 106106, Lactobacillus pantheris JCM 12539, Lactobacillus pantheris NBRC 106106

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRL86763.1	KRL86765.1	FC50_GL000407	FC50_GL000409	Oligopeptide ABC superfamily ATP binding cassette transporter, permease protein.	Oligopeptide ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily.	0.998
KRL86763.1	KRL86923.1	FC50_GL000407	FC50_GL000116	Oligopeptide ABC superfamily ATP binding cassette transporter, permease protein.	ABC superfamily ATP binding cassette transporter, ABC protein.	0.724
KRL86763.1	KRL88118.1	FC50_GL000407	FC50_GL000313	Oligopeptide ABC superfamily ATP binding cassette transporter, permease protein.	ABC-type dipeptide oligopeptide nickel transport system, ATPase component; Belongs to the ABC transporter superfamily.	0.989
KRL86763.1	KRL88195.1	FC50_GL000407	FC50_GL000052	Oligopeptide ABC superfamily ATP binding cassette transporter, permease protein.	Hypothetical protein.	0.724
KRL86765.1	KRL86763.1	FC50_GL000409	FC50_GL000407	Oligopeptide ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily.	Oligopeptide ABC superfamily ATP binding cassette transporter, permease protein.	0.998
KRL86765.1	KRL86923.1	FC50_GL000409	FC50_GL000116	Oligopeptide ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily.	ABC superfamily ATP binding cassette transporter, ABC protein.	0.740
KRL86765.1	KRL88120.1	FC50_GL000409	FC50_GL000315	Oligopeptide ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily.	ABC-type dipeptide oligopeptide nickel transport system, permease component.	0.995
KRL86765.1	KRL88195.1	FC50_GL000409	FC50_GL000052	Oligopeptide ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily.	Hypothetical protein.	0.740
KRL86922.1	KRL86923.1	FC50_GL000115	FC50_GL000116	Hypothetical protein.	ABC superfamily ATP binding cassette transporter, ABC protein.	0.979
KRL86922.1	KRL86924.1	FC50_GL000115	FC50_GL000117	Hypothetical protein.	ABC transporter, permease protein.	0.997
KRL86922.1	KRL88195.1	FC50_GL000115	FC50_GL000052	Hypothetical protein.	Hypothetical protein.	0.602
KRL86922.1	KRL88197.1	FC50_GL000115	FC50_GL000054	Hypothetical protein.	Hypothetical protein.	0.900
KRL86922.1	ecfA-2	FC50_GL000115	FC50_GL001020	Hypothetical protein.	Cobalt transporter ATP-binding subunit; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.886
KRL86922.1	ecfT	FC50_GL000115	FC50_GL001018	Hypothetical protein.	ABC-type cobalt transport system, permease component CbiQ related transporter; Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.	0.906
KRL86923.1	KRL86763.1	FC50_GL000116	FC50_GL000407	ABC superfamily ATP binding cassette transporter, ABC protein.	Oligopeptide ABC superfamily ATP binding cassette transporter, permease protein.	0.724
KRL86923.1	KRL86765.1	FC50_GL000116	FC50_GL000409	ABC superfamily ATP binding cassette transporter, ABC protein.	Oligopeptide ABC transporter ATP-binding protein; Belongs to the ABC transporter superfamily.	0.740
KRL86923.1	KRL86922.1	FC50_GL000116	FC50_GL000115	ABC superfamily ATP binding cassette transporter, ABC protein.	Hypothetical protein.	0.979
KRL86923.1	KRL86924.1	FC50_GL000116	FC50_GL000117	ABC superfamily ATP binding cassette transporter, ABC protein.	ABC transporter, permease protein.	0.998
KRL86923.1	KRL88118.1	FC50_GL000116	FC50_GL000313	ABC superfamily ATP binding cassette transporter, ABC protein.	ABC-type dipeptide oligopeptide nickel transport system, ATPase component; Belongs to the ABC transporter superfamily.	0.740
KRL86923.1	KRL88120.1	FC50_GL000116	FC50_GL000315	ABC superfamily ATP binding cassette transporter, ABC protein.	ABC-type dipeptide oligopeptide nickel transport system, permease component.	0.724

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

35

PPI enrichment p-value:

0.000481

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 310

1.69

3.81

2.30e-13

GO:0042254

Ribosome biogenesis

5 of 289

1.42

1.45

0.00014

GO:0042274

Ribosomal small subunit biogenesis

3 of 79

1.76

1.27

0.0024

GO:0071704

Organic substance metabolic process

11 of 4908

0.53

0.45

0.00026

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 152

2.0

5.84

9.88e-17

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022627

Cytosolic small ribosomal subunit

9 of 27

2.7

9.79

1.57e-20

GO:0005840

Ribosome

10 of 171

1.94

5.68

4.03e-17

GO:0005737

Cytoplasm

10 of 4816

0.5

0.39

0.0025

GO:0005622

Intracellular anatomical structure

11 of 7157

0.36

0.3

0.0065

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10092

Cytosolic small ribosomal subunit

9 of 25

2.73

9.95

1.06e-20

CL:10093

Cytosolic small ribosomal subunit

7 of 16

2.82

8.2

1.38e-16

CL:10006

GTP hydrolysis and joining of the 60S ribosomal subunit

10 of 93

2.21

7.61

1.48e-19

CL:9984

GTP hydrolysis and joining of the 60S ribosomal subunit, and Translation elongation factor activity

11 of 121

2.14

7.54

1.06e-20

CL:10124

Cytosolic small ribosomal subunit, and TNF signaling

2 of 9

2.52

1.43

0.0024

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 170

1.95

5.72

2.95e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72695

Formation of the ternary complex, and subsequently, the 43S complex

11 of 93

2.25

8.6

3.21e-22

MAP-72702

Ribosomal scanning and start codon recognition

11 of 101

2.22

8.37

3.78e-22

MAP-72706

GTP hydrolysis and joining of the 60S ribosomal subunit

11 of 114

2.16

7.97

8.90e-22

MAP-975956

Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)

11 of 127

2.12

7.6

2.07e-21

MAP-1799339

SRP-dependent cotranslational protein targeting to membrane

11 of 128

2.11

7.58

2.07e-21

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0022627

Cytosolic small ribosomal subunit

8 of 33

2.56

7.8

1.07e-16

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 132

2.06

6.47

4.15e-18

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