KRL86499.1 protein (Lactobacillus pantheris)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

KRL86499.1

Hypothetical protein. (301 aa)

Predicted Functional Partners:

KRL86498.1

0.753

KRL86497.1

0.739

KRL86496.1

0.720

KRL86493.1

0.659

KRL86495.1

0.590

KRL86492.1

0.550

KRL86487.1

0.543

KRL86494.1

0.541

fmt

0.499

KRL86001.1

0.496

Your Current Organism:

Lactobacillus pantheris

NCBI taxonomy Id: 1423783
Other names: L. pantheris DSM 15945 = JCM 12539 = NBRC 106106, Lactobacillus pantheris DSM 15945, Lactobacillus pantheris DSM 15945 = JCM 12539 = NBRC 106106, Lactobacillus pantheris JCM 12539, Lactobacillus pantheris NBRC 106106

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRL86001.1	KRL86495.1	FC50_GL001408	FC50_GL000744	Hypothetical protein.	Hypothetical protein.	0.500
KRL86001.1	KRL86499.1	FC50_GL001408	FC50_GL000748	Hypothetical protein.	Hypothetical protein.	0.496
KRL86487.1	KRL86495.1	FC50_GL000736	FC50_GL000744	Glycosyltransferase.	Hypothetical protein.	0.543
KRL86487.1	KRL86499.1	FC50_GL000736	FC50_GL000748	Glycosyltransferase.	Hypothetical protein.	0.543
KRL86487.1	fmt	FC50_GL000736	FC50_GL000470	Glycosyltransferase.	Methionyl-trna formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.	0.651
KRL86492.1	KRL86493.1	FC50_GL000741	FC50_GL000742	Lipopolysaccharide biosynthesis glycosyltransferase.	Glycosyltransferase.	0.781
KRL86492.1	KRL86494.1	FC50_GL000741	FC50_GL000743	Lipopolysaccharide biosynthesis glycosyltransferase.	Hypothetical protein.	0.445
KRL86492.1	KRL86495.1	FC50_GL000741	FC50_GL000744	Lipopolysaccharide biosynthesis glycosyltransferase.	Hypothetical protein.	0.482
KRL86492.1	KRL86496.1	FC50_GL000741	FC50_GL000745	Lipopolysaccharide biosynthesis glycosyltransferase.	Group 1 glycosyl transferase.	0.644
KRL86492.1	KRL86497.1	FC50_GL000741	FC50_GL000746	Lipopolysaccharide biosynthesis glycosyltransferase.	UDP-galactopyranose mutase.	0.928
KRL86492.1	KRL86498.1	FC50_GL000741	FC50_GL000747	Lipopolysaccharide biosynthesis glycosyltransferase.	PST family polysaccharide transporter.	0.953
KRL86492.1	KRL86499.1	FC50_GL000741	FC50_GL000748	Lipopolysaccharide biosynthesis glycosyltransferase.	Hypothetical protein.	0.550
KRL86493.1	KRL86492.1	FC50_GL000742	FC50_GL000741	Glycosyltransferase.	Lipopolysaccharide biosynthesis glycosyltransferase.	0.781
KRL86493.1	KRL86494.1	FC50_GL000742	FC50_GL000743	Glycosyltransferase.	Hypothetical protein.	0.594
KRL86493.1	KRL86495.1	FC50_GL000742	FC50_GL000744	Glycosyltransferase.	Hypothetical protein.	0.741
KRL86493.1	KRL86496.1	FC50_GL000742	FC50_GL000745	Glycosyltransferase.	Group 1 glycosyl transferase.	0.588
KRL86493.1	KRL86497.1	FC50_GL000742	FC50_GL000746	Glycosyltransferase.	UDP-galactopyranose mutase.	0.888
KRL86493.1	KRL86498.1	FC50_GL000742	FC50_GL000747	Glycosyltransferase.	PST family polysaccharide transporter.	0.782
KRL86493.1	KRL86499.1	FC50_GL000742	FC50_GL000748	Glycosyltransferase.	Hypothetical protein.	0.659
KRL86494.1	KRL86492.1	FC50_GL000743	FC50_GL000741	Hypothetical protein.	Lipopolysaccharide biosynthesis glycosyltransferase.	0.445

page 1 of 4

Network Stats

number of nodes:

5

number of edges:

7

average node degree:

2.8

avg. local clustering coefficient:

0.9

expected number of edges:

5

PPI enrichment p-value:

0.255

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

6 of 16

2.18

3.97

4.08e-09

GO:0031564

Transcription antitermination

3 of 3

2.61

2.28

5.92e-05

GO:0006353

DNA-templated transcription, termination

3 of 4

2.48

2.24

6.48e-05

GO:0034654

Nucleobase-containing compound biosynthetic process

7 of 165

1.24

1.43

1.06e-05

GO:0010467

Gene expression

7 of 235

1.08

1.1

6.48e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

3 of 9

2.13

1.41

0.0020

GO:0003676

Nucleic acid binding

7 of 589

0.68

0.42

0.0294

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

3 of 10

2.09

1.7

0.00048

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1641

Transcription, DNA-templated, and SNF2, N-terminal

6 of 14

2.24

4.22

1.51e-09

CL:1659

DNA-templated transcription, termination

3 of 5

2.39

2.19

7.37e-05

CL:1645

RNA polymerase

3 of 5

2.39

2.19

7.37e-05

CL:1417

Translation, and Purine nucleoside triphosphate biosynthetic process

7 of 126

1.35

1.73

2.49e-06

CL:1369

Mixed, incl. NAD(P)+ transhydrogenase activity, and NAD synthase

2 of 7

2.07

0.92

0.0188

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

3 of 5

2.39

2.18

7.51e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635486

Infection with Mycobacterium tuberculosis

3 of 84

1.16

0.65

0.0270

MAP-5663205

Infectious disease

3 of 88

1.14

0.64

0.0270

MAP-1643685

Disease

3 of 93

1.12

0.63

0.0270

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0008023

Transcription elongation factor complex

2 of 2

2.61

1.11

0.0097

GOCC:0000428

DNA-directed RNA polymerase complex

3 of 50

1.39

0.74

0.0237

GOCC:0005622

Intracellular

10 of 1477

0.44

0.32

0.0179

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0889

Transcription antitermination

3 of 3

2.61

2.35

4.47e-05

KW-0240

DNA-directed RNA polymerase

3 of 6

2.31

2.19

6.59e-05

KW-0804

Transcription

6 of 123

1.3

1.41

4.47e-05

KW-0806

Transcription termination

2 of 3

2.43

1.37

0.0029

KW-0548

Nucleotidyltransferase

3 of 46

1.42

0.93

0.0082

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