KRK83028.1 protein (Lactobacillus paralimentarius)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

KRK83028.1

Aryl-alcohol dehydrogenase. (373 aa)

Predicted Functional Partners:

KRK83515.1

0.991

KRK84026.1

0.928

KRK81563.1

0.908

KRK82987.1

0.908

tadA

0.779

KRK81605.1

0.774

KRK82281.1

0.741

KRK84033.1

0.690

KRK84023.1

0.682

KRK85083.1

0.633

Your Current Organism:

Lactobacillus paralimentarius

NCBI taxonomy Id: 1423788
Other names: L. paralimentarius DSM 19674, Lactobacillus paralimentarius DSM 19674

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRK81563.1	KRK82281.1	FC78_GL000616	FC78_GL002286	Esterase family protein.	Hypothetical protein.	0.582
KRK81563.1	KRK83028.1	FC78_GL000616	FC78_GL001835	Esterase family protein.	Aryl-alcohol dehydrogenase.	0.908
KRK81563.1	KRK83515.1	FC78_GL000616	FC78_GL001472	Esterase family protein.	Bifunctional acetaldehyde-CoA alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.432
KRK81563.1	KRK85083.1	FC78_GL000616	FC78_GL000888	Esterase family protein.	Alcohol dehydrogenase.	0.535
KRK81605.1	KRK83028.1	FC78_GL000658	FC78_GL001835	Guanine deaminase.	Aryl-alcohol dehydrogenase.	0.774
KRK81605.1	KRK83515.1	FC78_GL000658	FC78_GL001472	Guanine deaminase.	Bifunctional acetaldehyde-CoA alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.566
KRK81605.1	KRK84026.1	FC78_GL000658	FC78_GL001032	Guanine deaminase.	pduQ protein.	0.510
KRK82281.1	KRK81563.1	FC78_GL002286	FC78_GL000616	Hypothetical protein.	Esterase family protein.	0.582
KRK82281.1	KRK82987.1	FC78_GL002286	FC78_GL001793	Hypothetical protein.	Acetylesterase.	0.582
KRK82281.1	KRK83028.1	FC78_GL002286	FC78_GL001835	Hypothetical protein.	Aryl-alcohol dehydrogenase.	0.741
KRK82987.1	KRK82281.1	FC78_GL001793	FC78_GL002286	Acetylesterase.	Hypothetical protein.	0.582
KRK82987.1	KRK83028.1	FC78_GL001793	FC78_GL001835	Acetylesterase.	Aryl-alcohol dehydrogenase.	0.908
KRK82987.1	KRK83515.1	FC78_GL001793	FC78_GL001472	Acetylesterase.	Bifunctional acetaldehyde-CoA alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.432
KRK82987.1	KRK85083.1	FC78_GL001793	FC78_GL000888	Acetylesterase.	Alcohol dehydrogenase.	0.535
KRK83028.1	KRK81563.1	FC78_GL001835	FC78_GL000616	Aryl-alcohol dehydrogenase.	Esterase family protein.	0.908
KRK83028.1	KRK81605.1	FC78_GL001835	FC78_GL000658	Aryl-alcohol dehydrogenase.	Guanine deaminase.	0.774
KRK83028.1	KRK82281.1	FC78_GL001835	FC78_GL002286	Aryl-alcohol dehydrogenase.	Hypothetical protein.	0.741
KRK83028.1	KRK82987.1	FC78_GL001835	FC78_GL001793	Aryl-alcohol dehydrogenase.	Acetylesterase.	0.908
KRK83028.1	KRK83515.1	FC78_GL001835	FC78_GL001472	Aryl-alcohol dehydrogenase.	Bifunctional acetaldehyde-CoA alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.	0.991
KRK83028.1	KRK84023.1	FC78_GL001835	FC78_GL001029	Aryl-alcohol dehydrogenase.	Hypothetical protein.	0.682

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

24

PPI enrichment p-value:

2.24e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 114

1.5

2.88

8.83e-12

GO:0019538

Protein metabolic process

11 of 319

1.1

1.52

2.64e-10

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 54

1.83

4.7

4.78e-15

GO:0019843

rRNA binding

5 of 43

1.62

1.9

2.41e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 59

1.79

4.59

2.08e-15

GO:0005622

Intracellular anatomical structure

11 of 1577

0.4

0.34

0.0010

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:144

Ribosome

6 of 29

1.87

3.33

8.49e-09

CL:138

Ribosome

7 of 46

1.74

3.24

1.28e-09

CL:131

Ribosome, and Translation regulator activity

8 of 73

1.6

2.97

3.24e-10

CL:126

Ribosome, and Translation regulator activity

9 of 96

1.53

2.89

4.13e-11

CL:121

Translation, and Protein export

10 of 125

1.46

2.75

6.89e-12

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 56

1.81

4.75

1.06e-15

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

8 of 51

1.75

3.57

6.79e-11

GOCC:0043232

Intracellular non-membrane-bounded organelle

9 of 130

1.4

2.34

4.61e-10

GOCC:0015934

Large ribosomal subunit

3 of 14

1.89

1.61

0.00053

GOCC:0043229

Intracellular organelle

10 of 337

1.03

1.29

1.69e-08

GOCC:0022625

Cytosolic large ribosomal subunit

2 of 12

1.78

0.88

0.0188

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 59

1.79

4.56

3.06e-15

KW-0699

rRNA-binding

5 of 39

1.67

2.17

4.38e-06

KW-0488

Methylation

2 of 4

2.26

1.24

0.0048

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