BN53_06665 protein (Lactobacillus pasteurii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

BN53_06665

Histidine protein kinase. (426 aa)

Predicted Functional Partners:

BN53_06670

0.996

BN53_06780

0.966

BN53_06675

0.954

BN53_03145

0.932

BN53_08965

0.925

BN53_07135

0.911

ribB

0.902

BN53_04555

0.896

BN53_02860

0.887

BN53_02520

0.885

Your Current Organism:

Lactobacillus pasteurii

NCBI taxonomy Id: 1423790
Other names: L. pasteurii DSM 23907 = CRBIP 24.76, Lactobacillus pasteurii CRBIP 24.76, Lactobacillus pasteurii CRBIP 24.76 = DSM 23907, Lactobacillus pasteurii DSM 23907, Lactobacillus pasteurii DSM 23907 = CRBIP 24.76

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN53_02520	BN53_06665	BN53_02520	BN53_06665	D-ribose-binding protein.	Histidine protein kinase.	0.885
BN53_02860	BN53_04555	BN53_02860	BN53_04555	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.948
BN53_02860	BN53_06665	BN53_02860	BN53_06665	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex.	Histidine protein kinase.	0.887
BN53_03145	BN53_04555	BN53_03145	BN53_04555	Response regulator.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.835
BN53_03145	BN53_06665	BN53_03145	BN53_06665	Response regulator.	Histidine protein kinase.	0.932
BN53_03145	BN53_08965	BN53_03145	BN53_08965	Response regulator.	Response regulator.	0.467
BN53_03145	ribB	BN53_03145	BN53_05370	Response regulator.	3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family.	0.841
BN53_04555	BN53_02860	BN53_04555	BN53_02860	Pyruvate kinase; Belongs to the pyruvate kinase family.	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex.	0.948
BN53_04555	BN53_03145	BN53_04555	BN53_03145	Pyruvate kinase; Belongs to the pyruvate kinase family.	Response regulator.	0.835
BN53_04555	BN53_06665	BN53_04555	BN53_06665	Pyruvate kinase; Belongs to the pyruvate kinase family.	Histidine protein kinase.	0.896
BN53_04555	BN53_06670	BN53_04555	BN53_06670	Pyruvate kinase; Belongs to the pyruvate kinase family.	DNA-binding response regulator.	0.835
BN53_04555	BN53_06780	BN53_04555	BN53_06780	Pyruvate kinase; Belongs to the pyruvate kinase family.	Response regulator.	0.835
BN53_04555	BN53_07135	BN53_04555	BN53_07135	Pyruvate kinase; Belongs to the pyruvate kinase family.	DNA-binding response regulator.	0.835
BN53_04555	BN53_08965	BN53_04555	BN53_08965	Pyruvate kinase; Belongs to the pyruvate kinase family.	Response regulator.	0.835
BN53_06665	BN53_02520	BN53_06665	BN53_02520	Histidine protein kinase.	D-ribose-binding protein.	0.885
BN53_06665	BN53_02860	BN53_06665	BN53_02860	Histidine protein kinase.	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex.	0.887
BN53_06665	BN53_03145	BN53_06665	BN53_03145	Histidine protein kinase.	Response regulator.	0.932
BN53_06665	BN53_04555	BN53_06665	BN53_04555	Histidine protein kinase.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.896
BN53_06665	BN53_06670	BN53_06665	BN53_06670	Histidine protein kinase.	DNA-binding response regulator.	0.996
BN53_06665	BN53_06675	BN53_06665	BN53_06675	Histidine protein kinase.	GTP pyrophosphokinase family protein.	0.954

page 1 of 3

Network Stats

number of nodes:

5

number of edges:

9

average node degree:

3.6

avg. local clustering coefficient:

0.9

expected number of edges:

11

PPI enrichment p-value:

0.465

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2001295

malonyl-CoA biosynthetic process

2 of 3

2.29

1.15

0.0073

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003700

DNA-binding transcription factor activity

7 of 89

1.36

1.73

3.18e-06

GO:0016743

Carboxyl- or carbamoyltransferase activity

2 of 4

2.17

0.79

0.0348

GO:0003989

acetyl-CoA carboxylase activity

2 of 4

2.17

0.79

0.0348

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009317

acetyl-CoA carboxylase complex

2 of 3

2.29

1.3

0.0038

GO:0005737

Cytoplasm

11 of 1119

0.46

0.38

0.00095

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2244

Mixed, incl. The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to PUBMED:12757941. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules., and Peroxiredoxin activity

4 of 6

2.29

2.56

1.08e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01210

2-Oxocarboxylic acid metabolism

4 of 22

1.73

1.76

0.00012

map00300

Lysine biosynthesis

4 of 24

1.69

1.73

0.00012

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009317

acetyl-CoA carboxylase complex

2 of 4

2.17

0.75

0.0419

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0805

Transcription regulation

7 of 113

1.26

1.52

4.72e-06

KW-0238

DNA-binding

7 of 190

1.04

4.98e-05

KW-0275

Fatty acid biosynthesis

2 of 11

1.73

0.71

0.0408

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01039

Carboxyl transferase domain

2 of 2

2.47

0.83

0.0302

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00345

Helix_turn_helix gluconate operon transcriptional repressor

7 of 12

2.23

5.3

2.51e-12

SM00866

The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain that has a similar fold to PUBMED:12757941. It is believed to modulate activity of bacterial transcription factors in response to binding small molecules.

4 of 5

2.37

3.23

5.11e-07

SM00895

This entry represents the C-terminal ligand binding domain of many members of the GntR family. This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding ...

2 of 3

2.29

1.29

0.0040

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