STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrDDihydroorotate dehydrogenase 1B; Catalyzes the conversion of dihydroorotate to orotate. (322 aa)    
Predicted Functional Partners:
pyrB
Aspartate carbamoyltransferase catalytic subunit; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
 
 0.999
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
 0.999
pyrF
Orotidine 5-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
 
 0.999
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
 
 0.999
carB
Carbamoyl phosphate synthase large subunit; Belongs to the CarB family.
 
 0.996
carA
Carbamoyl phosphate synthase small subunit; Belongs to the CarA family.
 
  
 0.981
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
  
 0.961
KRL99991.1
Uracil permease.
  
  
 0.958
KRL97416.1
Glutamate synthase subunit beta.
 
 0.950
guaB
Inosine 5-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.937
Your Current Organism:
Lactobacillus satsumensis
NCBI taxonomy Id: 1423801
Other names: L. satsumensis DSM 16230 = JCM 12392, Lactobacillus satsumensis DSM 16230, Lactobacillus satsumensis DSM 16230 = JCM 12392, Lactobacillus satsumensis JCM 12392, Lactobacillus satsumensis JCM 12392 = DSM 16230
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.