STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KRN03327.1Ribonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (235 aa)    
Predicted Functional Partners:
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
   
 0.917
rnhB
Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
  
 
 0.859
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
 
 0.845
KRN01263.1
Single strand binding protein.
   
 
 0.691
KRN01206.1
Single-stranded DNA binding protein (Ssb).
   
 
 0.691
KRN02685.1
Single-stranded DNA binding protein (Ssb); Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
   
 
 0.691
KRN02616.1
Hypothetical protein.
  
     0.644
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
 0.631
KRN03328.1
Hypothetical protein.
       0.604
KRN03326.1
Hypothetical protein.
 
     0.574
Your Current Organism:
Lactobacillus senmaizukei
NCBI taxonomy Id: 1423803
Other names: L. senmaizukei DSM 21775 = NBRC 103853, Lactobacillus senmaizukei DSM 21775, Lactobacillus senmaizukei DSM 21775 = NBRC 103853, Lactobacillus senmaizukei L13, Lactobacillus senmaizukei NBRC 103853, Lactobacillus senmaizukei NBRC 103853 = DSM 21775
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.