dacA protein (Lactobacillus uvarum) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

dacA

Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (280 aa)

Predicted Functional Partners:

KRL37283.1

0.971

glmM

0.968

mutS2

0.708

KRL38870.1

0.656

KRL37281.1

0.650

argR

0.473

argR-2

0.473

Your Current Organism:

Lactobacillus uvarum

NCBI taxonomy Id: 1423812
Other names: L. uvarum DSM 19971, Lactobacillus sp. 8, Lactobacillus uvarum DSM 19971

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KRL37281.1	KRL37283.1	FD20_GL000461	FD20_GL000463	Hypothetical protein.	YbbR family protein.	0.647
KRL37281.1	dacA	FD20_GL000461	FD20_GL000462	Hypothetical protein.	Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.	0.650
KRL37281.1	glmM	FD20_GL000461	FD20_GL000464	Hypothetical protein.	Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	0.590
KRL37283.1	KRL37281.1	FD20_GL000463	FD20_GL000461	YbbR family protein.	Hypothetical protein.	0.647
KRL37283.1	dacA	FD20_GL000463	FD20_GL000462	YbbR family protein.	Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.	0.971
KRL37283.1	glmM	FD20_GL000463	FD20_GL000464	YbbR family protein.	Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	0.806
KRL38870.1	dacA	FD20_GL000945	FD20_GL000462	Phosphoglucomutase.	Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.	0.656
KRL38870.1	glmM	FD20_GL000945	FD20_GL000464	Phosphoglucomutase.	Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	0.501
argR	dacA	FD20_GL001300	FD20_GL000462	Arginine repressor; Regulates arginine biosynthesis genes.	Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.	0.473
argR-2	dacA	FD20_GL001708	FD20_GL000462	Arginine catabolic regulator; Regulates arginine biosynthesis genes.	Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.	0.473
dacA	KRL37281.1	FD20_GL000462	FD20_GL000461	Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.	Hypothetical protein.	0.650
dacA	KRL37283.1	FD20_GL000462	FD20_GL000463	Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.	YbbR family protein.	0.971
dacA	KRL38870.1	FD20_GL000462	FD20_GL000945	Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.	Phosphoglucomutase.	0.656
dacA	argR	FD20_GL000462	FD20_GL001300	Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.	Arginine repressor; Regulates arginine biosynthesis genes.	0.473
dacA	argR-2	FD20_GL000462	FD20_GL001708	Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.	Arginine catabolic regulator; Regulates arginine biosynthesis genes.	0.473
dacA	glmM	FD20_GL000462	FD20_GL000464	Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.	Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	0.968
dacA	mutS2	FD20_GL000462	FD20_GL000854	Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.	DNA mismatch repair protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.	0.708
glmM	KRL37281.1	FD20_GL000464	FD20_GL000461	Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	Hypothetical protein.	0.590
glmM	KRL37283.1	FD20_GL000464	FD20_GL000463	Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	YbbR family protein.	0.806
glmM	KRL38870.1	FD20_GL000464	FD20_GL000945	Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.	Phosphoglucomutase.	0.501

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Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.782

expected number of edges:

11

PPI enrichment p-value:

0.000292

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006749

Glutathione metabolic process

3 of 47

2.11

1.09

0.0090

GO:0006534

Cysteine metabolic process

2 of 8

2.71

1.03

0.0133

GO:0009064

Glutamine family amino acid metabolic process

3 of 65

1.97

1.01

0.0117

GO:0006750

Glutathione biosynthetic process

2 of 10

2.61

1.01

0.0146

GO:1901605

Alpha-amino acid metabolic process

4 of 170

1.68

1.0

0.0090

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 44

2.14

1.28

0.0037

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005814

Centriole

3 of 108

1.75

0.83

0.0239

GO:0005813

Centrosome

4 of 413

1.29

0.71

0.0239

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:28614

Glutathione metabolism, and Oxidoreductase activity, acting on a sulfur group of donors

8 of 127

2.11

5.12

1.06e-12

CL:28680

Gamma-glutamyltranspeptidase, and Glutamate-cysteine ligase complex

3 of 7

2.94

2.75

9.75e-06

CL:28789

Mixed, incl. Metalloaminopeptidase activity, and Aspartate and asparagine metabolism

4 of 38

2.33

2.64

8.07e-06

CL:28620

Glutathione conjugation, and Glutathione peroxidase

4 of 39

2.32

2.63

8.07e-06

CL:28845

Negative regulation of cilium assembly, and Domain in ubiquitin-specific proteases.

3 of 10

2.79

2.57

1.94e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00480

Glutathione metabolism

5 of 126

1.91

2.78

5.66e-07

map00270

Cysteine and methionine metabolism

4 of 78

2.02

2.52

5.36e-06

map00250

Alanine, aspartate and glutamate metabolism

2 of 64

1.8

0.84

0.0229

map04216

Ferroptosis

2 of 74

1.74

0.82

0.0243

map01100

Metabolic pathways

9 of 3053

0.78

0.72

4.65e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-174403

Glutathione synthesis and recycling

4 of 19

2.63

3.37

4.63e-07

MAP-156590

Glutathione conjugation

4 of 34

2.38

2.96

1.92e-06

MAP-156580

Phase II - Conjugation of compounds

4 of 95

1.93

2.02

6.44e-05

MAP-211859

Biological oxidations

4 of 254

1.51

1.17

0.0022

MAP-5620912

Anchoring of the basal body to the plasma membrane

3 of 105

1.76

1.11

0.0058

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0097721

Ciliary vesicle

2 of 4

3.01

1.32

0.0042

GOCC:0005814

Centriole

3 of 59

2.01

1.23

0.0042

GOCC:0005815

Microtubule organizing center

4 of 215

1.58

1.1

0.0042

GOCC:0005813

Centrosome

3 of 120

1.71

0.99

0.0098

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