STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdhBTransketolase, C-terminal domain protein; COG: COG0022. (325 aa)    
Predicted Functional Partners:
pdhA
Pyruvate dehydrogenase E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
 0.999
EEJ41344.1
2-oxo acid dehydrogenase acyltransferase (catalytic domain); COG: COG0508.
 0.999
lpdA
Dihydrolipoyl dehydrogenase; COG: COG1249.
 0.999
EEJ40254.1
Pyridine nucleotide-disulfide oxidoreductase; COG: COG1249.
 
 0.993
prs
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 0.958
prs-2
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 0.958
malS
Malic enzyme, NAD binding domain protein; COG: COG0281.
  
 
 0.949
pyk
Pyruvate kinase; COG: COG0469; Belongs to the pyruvate kinase family.
  
 
 0.947
EEJ40057.1
Lactate/malate dehydrogenase, NAD binding domain protein; COG: COG0039.
  
 0.946
fabG3
Oxidoreductase, short chain dehydrogenase/reductase family protein; COG: COG1028.
  
 0.941
Your Current Organism:
Lactobacillus vaginalis
NCBI taxonomy Id: 1423814
Other names: L. vaginalis DSM 5837 = ATCC 49540, Lactobacillus vaginalis ATCC 49540, Lactobacillus vaginalis ATCC 49540 = DSM 5837, Lactobacillus vaginalis DSM 5837, Lactobacillus vaginalis DSM 5837 = ATCC 49540
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.