AOT69183.1 protein (Geosporobacter ferrireducens)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AOT69183.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)

Predicted Functional Partners:

AOT69182.1

0.945

AOT71111.1

0.924

AOT70774.1

0.841

AOT69184.1

0.824

AOT69041.1

0.794

AOT69046.1

0.792

AOT69139.1

0.786

AOT69185.1

0.773

AOT69047.1

0.765

AOT69208.1

0.762

Your Current Organism:

Geosporobacter ferrireducens

NCBI taxonomy Id: 1424294
Other names: G. ferrireducens, Geosporobacter sp. IRF9, JCM 19987, KCTC 15395, strain IRF9

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOT69041.1	AOT69183.1	Gferi_05390	Gferi_06160	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.794
AOT69041.1	AOT70774.1	Gferi_05390	Gferi_15040	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.591
AOT69041.1	AOT71111.1	Gferi_05390	Gferi_17080	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.442
AOT69046.1	AOT69047.1	Gferi_05415	Gferi_05420	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.820
AOT69046.1	AOT69183.1	Gferi_05415	Gferi_06160	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.792
AOT69046.1	AOT70774.1	Gferi_05415	Gferi_15040	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.580
AOT69046.1	AOT71111.1	Gferi_05415	Gferi_17080	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.411
AOT69047.1	AOT69046.1	Gferi_05420	Gferi_05415	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.820
AOT69047.1	AOT69183.1	Gferi_05420	Gferi_06160	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.765
AOT69047.1	AOT70774.1	Gferi_05420	Gferi_15040	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.833
AOT69139.1	AOT69183.1	Gferi_05930	Gferi_06160	DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.786
AOT69139.1	AOT70774.1	Gferi_05930	Gferi_15040	DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.547
AOT69182.1	AOT69183.1	Gferi_06155	Gferi_06160	DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.945
AOT69182.1	AOT69184.1	Gferi_06155	Gferi_06165	DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.810
AOT69182.1	AOT69185.1	Gferi_06155	Gferi_06170	DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
AOT69182.1	AOT70774.1	Gferi_06155	Gferi_15040	DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.547
AOT69183.1	AOT69041.1	Gferi_06160	Gferi_05390	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.794
AOT69183.1	AOT69046.1	Gferi_06160	Gferi_05415	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.792
AOT69183.1	AOT69047.1	Gferi_06160	Gferi_05420	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.765
AOT69183.1	AOT69139.1	Gferi_06160	Gferi_05930	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.786

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.823

expected number of edges:

11

PPI enrichment p-value:

1.3e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

8 of 26

2.04

4.96

8.45e-13

GO:0000160

Phosphorelay signal transduction system

9 of 47

1.84

4.28

7.99e-13

GO:0050794

Regulation of cellular process

10 of 372

0.98

1.17

6.21e-08

GO:0006355

Regulation of transcription, DNA-templated

5 of 266

0.83

0.5

0.0265

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

9 of 27

2.08

5.72

5.75e-15

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045121

Membrane raft

3 of 22

1.69

1.35

0.0013

GO:0016021

Integral component of membrane

10 of 941

0.58

0.48

0.00059

GO:0005886

Plasma membrane

8 of 948

0.48

0.34

0.0169

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4951

Phosphorelay signal transduction system, and Nucleotide cyclase

11 of 55

1.86

5.34

1.03e-17

CL:4953

Phosphorelay signal transduction system, and Nucleotide cyclase

9 of 35

1.97

5.11

2.62e-14

CL:4955

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and OmpR/PhoB-type DNA-binding domain

6 of 16

2.13

4.18

7.10e-10

CL:4957

Two-component regulatory system, and Histidine kinase N terminal

5 of 11

2.21

3.69

2.44e-08

CL:4969

Two-component regulatory system

3 of 5

2.33

2.15

7.94e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

far02020

Two-component system

8 of 90

1.5

2.57

1.76e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016020

Membrane

10 of 700

0.71

0.63

8.76e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

9 of 106

1.48

2.68

1.23e-10

KW-0902

Two-component regulatory system

4 of 13

2.04

2.47

8.24e-06

KW-0067

ATP-binding

7 of 299

0.92

0.85

0.00017

KW-0175

Coiled coil

8 of 414

0.84

0.77

0.00011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

9 of 20

2.21

6.37

1.39e-15

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

9 of 21

2.19

6.3

1.39e-15

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

9 of 23

2.15

6.16

1.39e-15

IPR005467

Histidine kinase domain

9 of 26

2.09

5.89

2.44e-15

IPR003594

Histidine kinase/HSP90-like ATPase

9 of 32

2.0

5.38

9.65e-15

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

9 of 21

2.19

6.59

1.66e-16

SM00387

Histidine kinase-like ATPases

9 of 32

2.0

5.55

2.02e-15

SM00304

HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain

5 of 10

2.25

3.99

5.91e-09

SM00091

PAS domain

6 of 23

1.97

3.73

1.87e-09

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 11

1.81

0.93

0.0151

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