AOT70604.1 protein (Geosporobacter ferrireducens)

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

AOT70604.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (284 aa)

Predicted Functional Partners:

AOT70605.1

0.598

AOT68501.1

0.557

AOT70603.1

0.492

AOT71792.1

0.453

hisC

0.438

AOT71414.1

0.431

AOT71413.1

0.420

Your Current Organism:

Geosporobacter ferrireducens

NCBI taxonomy Id: 1424294
Other names: G. ferrireducens, Geosporobacter sp. IRF9, JCM 19987, KCTC 15395, strain IRF9

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOT68501.1	AOT70604.1	Gferi_02170	Gferi_14105	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.557
AOT70603.1	AOT70604.1	Gferi_14100	Gferi_14105	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.492
AOT70604.1	AOT68501.1	Gferi_14105	Gferi_02170	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.557
AOT70604.1	AOT70603.1	Gferi_14105	Gferi_14100	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.492
AOT70604.1	AOT70605.1	Gferi_14105	Gferi_14110	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.598
AOT70604.1	AOT71413.1	Gferi_14105	Gferi_18900	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.420
AOT70604.1	AOT71414.1	Gferi_14105	Gferi_18905	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA helicase II; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.431
AOT70604.1	AOT71792.1	Gferi_14105	Gferi_20995	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.453
AOT70604.1	hisC	Gferi_14105	Gferi_25825	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidinol-phosphate transaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.438
AOT70605.1	AOT70604.1	Gferi_14110	Gferi_14105	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.598
AOT71413.1	AOT70604.1	Gferi_18900	Gferi_14105	ATP-dependent endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.420
AOT71413.1	AOT71414.1	Gferi_18900	Gferi_18905	ATP-dependent endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA helicase II; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.959
AOT71414.1	AOT70604.1	Gferi_18905	Gferi_14105	DNA helicase II; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.431
AOT71414.1	AOT71413.1	Gferi_18905	Gferi_18900	DNA helicase II; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATP-dependent endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.959
AOT71792.1	AOT70604.1	Gferi_20995	Gferi_14105	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.453
AOT71792.1	hisC	Gferi_20995	Gferi_25825	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidinol-phosphate transaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	0.649
hisC	AOT70604.1	Gferi_25825	Gferi_14105	Histidinol-phosphate transaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.438
hisC	AOT71792.1	Gferi_25825	Gferi_20995	Histidinol-phosphate transaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.649

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.822

expected number of edges:

16

PPI enrichment p-value:

9.64e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070403

NAD+ binding

3 of 4

2.39

1.74

0.00055

GO:0008410

CoA-transferase activity

3 of 9

2.04

1.43

0.0017

GO:0003857

3-hydroxyacyl-CoA dehydrogenase activity

2 of 2

2.52

1.2

0.0064

GO:0016616

Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

4 of 47

1.45

1.1

0.0027

GO:0004300

enoyl-CoA hydratase activity

2 of 3

2.34

1.1

0.0092

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1889

Mixed, incl. Coenzyme A transferase, and Dioxygenase

5 of 11

2.18

3.39

1.02e-07

CL:1865

Mixed, incl. Degradation of aromatic compounds, and Coenzyme A transferase

6 of 23

1.94

3.28

2.70e-08

CL:1511

Carbon metabolism, and Oxidoreductase activity

11 of 200

1.26

2.04

1.56e-11

CL:1706

NAD+ binding, and Beta-ketoacyl synthase, N-terminal domain

3 of 13

1.88

1.42

0.0014

CL:1700

Mixed, incl. Enoyl-CoA hydratase/isomerase, and Oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor

4 of 34

1.59

1.4

0.00065

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00650

Butanoate metabolism

8 of 52

1.71

3.43

6.57e-11

map00362

Benzoate degradation

4 of 35

1.58

1.55

0.00022

map00071

Fatty acid degradation

3 of 17

1.77

1.5

0.00070

map00281

Geraniol degradation

2 of 3

2.34

1.48

0.0017

map00072

Synthesis and degradation of ketone bodies

2 of 10

1.82

1.05

0.0083

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

3 of 13

1.88

1.25

0.0034

GOCC:0009346

Citrate lyase complex

2 of 4

2.22

1.02

0.0125

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00725

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain

3 of 4

2.39

1.8

0.00042

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006176

3-hydroxyacyl-CoA dehydrogenase, NAD binding

3 of 4

2.39

1.59

0.0011

IPR006108

3-hydroxyacyl-CoA dehydrogenase, C-terminal

3 of 4

2.39

1.59

0.0011

IPR004165

Coenzyme A transferase family I

3 of 6

2.22

1.56

0.0011

IPR008927

6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily

3 of 16

1.79

1.07

0.0075

IPR037171

NagB/RpiA transferase-like

3 of 22

1.65

0.91

0.0141

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00882

Coenzyme A transferase

3 of 6

2.22

1.92

0.00020

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