node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SER69615.1 | SER69635.1 | SAMN04488559_103155 | SAMN04488559_103156 | 16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Protein phosphatase. | 0.918 |
SER69615.1 | SER77156.1 | SAMN04488559_103155 | SAMN04488559_105147 | 16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.457 |
SER69615.1 | def | SAMN04488559_103155 | SAMN04488559_103153 | 16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.839 |
SER69615.1 | fmt | SAMN04488559_103155 | SAMN04488559_103154 | 16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.992 |
SER69615.1 | priA | SAMN04488559_103155 | SAMN04488559_103152 | 16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | Replication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.800 |
SER69635.1 | SER69615.1 | SAMN04488559_103156 | SAMN04488559_103155 | Protein phosphatase. | 16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.918 |
SER69635.1 | def | SAMN04488559_103156 | SAMN04488559_103153 | Protein phosphatase. | Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. | 0.750 |
SER69635.1 | fmt | SAMN04488559_103156 | SAMN04488559_103154 | Protein phosphatase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.955 |
SER69635.1 | priA | SAMN04488559_103156 | SAMN04488559_103152 | Protein phosphatase. | Replication restart DNA helicase PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.805 |
SER77156.1 | SER69615.1 | SAMN04488559_105147 | SAMN04488559_103155 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 16S rRNA (cytosine967-C5)-methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.457 |
SER77156.1 | SER81100.1 | SAMN04488559_105147 | SAMN04488559_106136 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Acyl-CoA reductase; Belongs to the aldehyde dehydrogenase family. | 0.430 |
SER77156.1 | SES06787.1 | SAMN04488559_105147 | SAMN04488559_12612 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formiminotetrahydrofolate cyclodeaminase. | 0.477 |
SER77156.1 | fmt | SAMN04488559_105147 | SAMN04488559_103154 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.932 |
SER77156.1 | folD | SAMN04488559_105147 | SAMN04488559_11737 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.560 |
SER77156.1 | glyA | SAMN04488559_105147 | SAMN04488559_101174 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.935 |
SER81100.1 | SER77156.1 | SAMN04488559_106136 | SAMN04488559_105147 | Acyl-CoA reductase; Belongs to the aldehyde dehydrogenase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.430 |
SER81100.1 | SES06787.1 | SAMN04488559_106136 | SAMN04488559_12612 | Acyl-CoA reductase; Belongs to the aldehyde dehydrogenase family. | Formiminotetrahydrofolate cyclodeaminase. | 0.472 |
SER81100.1 | fmt | SAMN04488559_106136 | SAMN04488559_103154 | Acyl-CoA reductase; Belongs to the aldehyde dehydrogenase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.904 |
SER81100.1 | folD | SAMN04488559_106136 | SAMN04488559_11737 | Acyl-CoA reductase; Belongs to the aldehyde dehydrogenase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.498 |
SER81100.1 | glyA | SAMN04488559_106136 | SAMN04488559_101174 | Acyl-CoA reductase; Belongs to the aldehyde dehydrogenase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.476 |