STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ALF11584.1Competence protein ComE; Derived by automated computational analysis using gene prediction method: Protein Homology. (151 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.942
tdk
Thymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.936
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
 0.931
ALF11981.1
Deoxycytidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.922
ALF10717.1
5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.
  
 
  0.906
ALF08610.1
5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family.
  
 
  0.905
cmk
Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.903
ALF11583.1
Competence protein ComEC; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.865
ALF11489.1
Xaa-Pro dipeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
    0.607
ALF10704.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
  
  
 0.430
Your Current Organism:
Parageobacillus thermoglucosidasius
NCBI taxonomy Id: 1426
Other names: ATCC 43742, BGSC 95A1, Bacillus sp. BGSC W9A92, Bacillus thermoglucosidasius, CCUG 28887, CIP 106930, DSM 2542, Geobacillus thermoglucosidans, Geobacillus thermoglucosidasius, LMG 7137, LMG:7137, NBRC 107763, NCIMB 11955, NRRL B-14516, P. thermoglucosidasius, Parageobacillus thermoglucosidans, strain R-35637
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