node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHM26403.1 | SHM86415.1 | SAMN05878281_0086 | SAMN05878281_2313 | 4-hydroxy 2-oxovalerate aldolase. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.764 |
SHM26403.1 | SHN09530.1 | SAMN05878281_0086 | SAMN05878281_3573 | 4-hydroxy 2-oxovalerate aldolase. | Acetolactate synthase, large subunit. | 0.846 |
SHM26403.1 | SHN09540.1 | SAMN05878281_0086 | SAMN05878281_3574 | 4-hydroxy 2-oxovalerate aldolase. | Acetolactate synthase, small subunit. | 0.895 |
SHM26403.1 | ilvC | SAMN05878281_0086 | SAMN05878281_3575 | 4-hydroxy 2-oxovalerate aldolase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.723 |
SHM26403.1 | ilvD | SAMN05878281_0086 | SAMN05878281_0181 | 4-hydroxy 2-oxovalerate aldolase. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.860 |
SHM26403.1 | ilvD-2 | SAMN05878281_0086 | SAMN05878281_3572 | 4-hydroxy 2-oxovalerate aldolase. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.860 |
SHM26403.1 | leuB | SAMN05878281_0086 | SAMN05878281_3586 | 4-hydroxy 2-oxovalerate aldolase. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.823 |
SHM26403.1 | leuC | SAMN05878281_0086 | SAMN05878281_3588 | 4-hydroxy 2-oxovalerate aldolase. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.930 |
SHM26403.1 | leuD | SAMN05878281_0086 | SAMN05878281_3587 | 4-hydroxy 2-oxovalerate aldolase. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.938 |
SHM86415.1 | SHM26403.1 | SAMN05878281_2313 | SAMN05878281_0086 | Pyruvate kinase; Belongs to the pyruvate kinase family. | 4-hydroxy 2-oxovalerate aldolase. | 0.764 |
SHM86415.1 | SHN09530.1 | SAMN05878281_2313 | SAMN05878281_3573 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Acetolactate synthase, large subunit. | 0.864 |
SHM86415.1 | SHN09790.1 | SAMN05878281_2313 | SAMN05878281_3589 | Pyruvate kinase; Belongs to the pyruvate kinase family. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.764 |
SHM86415.1 | leuC | SAMN05878281_2313 | SAMN05878281_3588 | Pyruvate kinase; Belongs to the pyruvate kinase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.833 |
SHM86415.1 | leuD | SAMN05878281_2313 | SAMN05878281_3587 | Pyruvate kinase; Belongs to the pyruvate kinase family. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.831 |
SHN09530.1 | SHM26403.1 | SAMN05878281_3573 | SAMN05878281_0086 | Acetolactate synthase, large subunit. | 4-hydroxy 2-oxovalerate aldolase. | 0.846 |
SHN09530.1 | SHM86415.1 | SAMN05878281_3573 | SAMN05878281_2313 | Acetolactate synthase, large subunit. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.864 |
SHN09530.1 | SHN09540.1 | SAMN05878281_3573 | SAMN05878281_3574 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |
SHN09530.1 | SHN09790.1 | SAMN05878281_3573 | SAMN05878281_3589 | Acetolactate synthase, large subunit. | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.933 |
SHN09530.1 | ilvC | SAMN05878281_3573 | SAMN05878281_3575 | Acetolactate synthase, large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.997 |
SHN09530.1 | ilvD | SAMN05878281_3573 | SAMN05878281_0181 | Acetolactate synthase, large subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.955 |