SMC41026.1 protein (Moheibacter sediminis) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

SMC41026.1

Hypothetical protein. (322 aa)

Predicted Functional Partners:

SMC41066.1

0.888

SMC41002.1

0.674

SMC40803.1

0.553

SMC89510.1

0.551

SMC36730.1

0.546

SMC41012.1

0.507

SMC40992.1

0.505

SMC59367.1

0.505

SMC75600.1

0.505

SMC75690.1

0.475

Your Current Organism:

Moheibacter sediminis

NCBI taxonomy Id: 1434700
Other names: CGMCC 1.12708, Empedobacter sp. M0116, JCM 19634, M. sediminis, Moheibacter sediminis Zhang et al. 2014, strain M0116

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SMC36730.1	SMC40992.1	SAMN06296427_101497	SAMN06296427_10224	Adenine-specific DNA methylase, N12 class.	Type I restriction enzyme, S subunit.	0.735
SMC36730.1	SMC41002.1	SAMN06296427_101497	SAMN06296427_10225	Adenine-specific DNA methylase, N12 class.	Type I restriction enzyme, S subunit.	0.735
SMC36730.1	SMC41026.1	SAMN06296427_101497	SAMN06296427_10227	Adenine-specific DNA methylase, N12 class.	Hypothetical protein.	0.546
SMC36730.1	SMC41066.1	SAMN06296427_101497	SAMN06296427_10228	Adenine-specific DNA methylase, N12 class.	Type I restriction enzyme, R subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification.	0.878
SMC36730.1	SMC59367.1	SAMN06296427_101497	SAMN06296427_104114	Adenine-specific DNA methylase, N12 class.	Type I restriction enzyme, S subunit.	0.784
SMC36730.1	SMC75600.1	SAMN06296427_101497	SAMN06296427_10781	Adenine-specific DNA methylase, N12 class.	Restriction endonuclease S subunit.	0.766
SMC40803.1	SMC41026.1	SAMN06296427_10212	SAMN06296427_10227	Hypothetical protein.	Hypothetical protein.	0.553
SMC40992.1	SMC36730.1	SAMN06296427_10224	SAMN06296427_101497	Type I restriction enzyme, S subunit.	Adenine-specific DNA methylase, N12 class.	0.735
SMC40992.1	SMC41012.1	SAMN06296427_10224	SAMN06296427_10226	Type I restriction enzyme, S subunit.	Site-specific recombinase XerD; Belongs to the 'phage' integrase family.	0.461
SMC40992.1	SMC41026.1	SAMN06296427_10224	SAMN06296427_10227	Type I restriction enzyme, S subunit.	Hypothetical protein.	0.505
SMC40992.1	SMC41066.1	SAMN06296427_10224	SAMN06296427_10228	Type I restriction enzyme, S subunit.	Type I restriction enzyme, R subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification.	0.936
SMC40992.1	SMC89510.1	SAMN06296427_10224	SAMN06296427_11225	Type I restriction enzyme, S subunit.	Helicase conserved C-terminal domain-containing protein.	0.735
SMC41002.1	SMC36730.1	SAMN06296427_10225	SAMN06296427_101497	Type I restriction enzyme, S subunit.	Adenine-specific DNA methylase, N12 class.	0.735
SMC41002.1	SMC41012.1	SAMN06296427_10225	SAMN06296427_10226	Type I restriction enzyme, S subunit.	Site-specific recombinase XerD; Belongs to the 'phage' integrase family.	0.689
SMC41002.1	SMC41026.1	SAMN06296427_10225	SAMN06296427_10227	Type I restriction enzyme, S subunit.	Hypothetical protein.	0.674
SMC41002.1	SMC41066.1	SAMN06296427_10225	SAMN06296427_10228	Type I restriction enzyme, S subunit.	Type I restriction enzyme, R subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification.	0.952
SMC41002.1	SMC75600.1	SAMN06296427_10225	SAMN06296427_10781	Type I restriction enzyme, S subunit.	Restriction endonuclease S subunit.	0.474
SMC41002.1	SMC89510.1	SAMN06296427_10225	SAMN06296427_11225	Type I restriction enzyme, S subunit.	Helicase conserved C-terminal domain-containing protein.	0.735
SMC41012.1	SMC40992.1	SAMN06296427_10226	SAMN06296427_10224	Site-specific recombinase XerD; Belongs to the 'phage' integrase family.	Type I restriction enzyme, S subunit.	0.461
SMC41012.1	SMC41002.1	SAMN06296427_10226	SAMN06296427_10225	Site-specific recombinase XerD; Belongs to the 'phage' integrase family.	Type I restriction enzyme, S subunit.	0.689

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Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.914

expected number of edges:

19

PPI enrichment p-value:

0.0062

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005975

Carbohydrate metabolic process

9 of 357

1.19

1.53

2.78e-07

GO:0051161

Arabitol metabolic process

2 of 2

2.79

1.08

0.0113

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004475

mannose-1-phosphate guanylyltransferase activity

3 of 3

2.79

2.37

4.44e-05

GO:0047813

D-arabinitol 4-dehydrogenase activity

2 of 2

2.79

1.42

0.0026

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 268

1.21

1.29

4.44e-05

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1061

Carbohydrate kinase, FGGY, N-terminal, and Arabitol metabolic process

4 of 5

2.69

3.31

6.82e-07

CL:923

Mixed, incl. Pentose phosphate pathway, and Glycolysis / Gluconeogenesis

6 of 83

1.65

2.29

1.37e-06

CL:1019

Phosphotransferase system (PTS), and ROK family

2 of 5

2.39

1.14

0.0081

CL:4718

Mixed, incl. O-Antigen nucleotide sugar biosynthesis, and Peptidyl-tyrosine modification

3 of 41

1.65

1.03

0.0074

CL:4723

Peptidyl-tyrosine modification, and Bacterial sugar transferase

2 of 15

1.91

0.78

0.0332

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00040

Pentose and glucuronate interconversions

5 of 31

2.0

3.06

1.98e-07

map00051

Fructose and mannose metabolism

5 of 50

1.79

2.55

9.03e-07

map00541

O-Antigen nucleotide sugar biosynthesis

3 of 31

1.77

1.46

0.00086

map02060

Phosphotransferase system (PTS)

2 of 8

2.19

1.29

0.0037

map00520

Amino sugar and nucleotide sugar metabolism

3 of 77

1.38

0.93

0.0068

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08125

Mannitol dehydrogenase C-terminal domain

2 of 2

2.79

1.2

0.0068

PF00483

Nucleotidyl transferase

2 of 2

2.79

1.2

0.0068

PF07883

Cupin domain

3 of 23

1.9

1.11

0.0068

PF02782

FGGY family of carbohydrate kinases, C-terminal domain

2 of 5

2.39

1.08

0.0105

PF00370

FGGY family of carbohydrate kinases, N-terminal domain

2 of 5

2.39

1.08

0.0105

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006375

Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase

3 of 3

2.79

2.12

0.00013

IPR001538

Mannose-6-phosphate isomerase, type II, C-terminal

3 of 3

2.79

2.12

0.00013

IPR005835

Nucleotidyl transferase domain

3 of 9

2.31

1.77

0.00046

IPR013118

Mannitol dehydrogenase, C-terminal

2 of 2

2.79

1.19

0.0071

IPR029044

Nucleotide-diphospho-sugar transferases

3 of 35

1.72

0.99

0.0104

(more ...)

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