LOC103372825 protein (Stegastes partitus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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Coexpression

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[Homology]

Score

LOC103372825

Zgc:171558. (909 aa)

Predicted Functional Partners:

ENSSPAP00000017331

0.909

ENSSPAP00000017360

0.909

RIMS2

0.909

LOC103354437

0.855

rap1a

0.855

LOC103368175

0.855

adcy6

0.834

LOC103363729

0.834

adcy7

0.831

LOC103368946

0.829

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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... protein annotations:

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000017331	ENSSPAP00000017360	ENSSPAP00000017331	ENSSPAP00000017360	C2 domain-containing protein.	PDZ domain-containing protein.	0.984
ENSSPAP00000017331	LOC103372825	ENSSPAP00000017331	ENSSPAP00000004231	C2 domain-containing protein.	Zgc:171558.	0.909
ENSSPAP00000017331	RIMS2	ENSSPAP00000017331	ENSSPAP00000026430	C2 domain-containing protein.	Regulating synaptic membrane exocytosis 2.	0.867
ENSSPAP00000017360	ENSSPAP00000017331	ENSSPAP00000017360	ENSSPAP00000017331	PDZ domain-containing protein.	C2 domain-containing protein.	0.984
ENSSPAP00000017360	LOC103372825	ENSSPAP00000017360	ENSSPAP00000004231	PDZ domain-containing protein.	Zgc:171558.	0.909
ENSSPAP00000017360	RIMS2	ENSSPAP00000017360	ENSSPAP00000026430	PDZ domain-containing protein.	Regulating synaptic membrane exocytosis 2.	0.867
LOC103354437	LOC103363729	ENSSPAP00000019043	ENSSPAP00000026422	RAP1A, member of RAS oncogene family a.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.465
LOC103354437	LOC103368175	ENSSPAP00000019043	ENSSPAP00000028612	RAP1A, member of RAS oncogene family a.	Uncharacterized protein.	0.899
LOC103354437	LOC103368946	ENSSPAP00000019043	ENSSPAP00000005782	RAP1A, member of RAS oncogene family a.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.465
LOC103354437	LOC103372825	ENSSPAP00000019043	ENSSPAP00000004231	RAP1A, member of RAS oncogene family a.	Zgc:171558.	0.855
LOC103354437	adcy6	ENSSPAP00000019043	ENSSPAP00000021922	RAP1A, member of RAS oncogene family a.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.465
LOC103354437	adcy7	ENSSPAP00000019043	ENSSPAP00000026817	RAP1A, member of RAS oncogene family a.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.465
LOC103354437	rap1a	ENSSPAP00000019043	ENSSPAP00000019988	RAP1A, member of RAS oncogene family a.	Uncharacterized protein.	0.899
LOC103363729	LOC103354437	ENSSPAP00000026422	ENSSPAP00000019043	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	RAP1A, member of RAS oncogene family a.	0.465
LOC103363729	LOC103368175	ENSSPAP00000026422	ENSSPAP00000028612	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.465
LOC103363729	LOC103368946	ENSSPAP00000026422	ENSSPAP00000005782	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.523
LOC103363729	LOC103372825	ENSSPAP00000026422	ENSSPAP00000004231	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Zgc:171558.	0.834
LOC103363729	adcy7	ENSSPAP00000026422	ENSSPAP00000026817	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.792
LOC103363729	rap1a	ENSSPAP00000026422	ENSSPAP00000019988	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.465
LOC103368175	LOC103354437	ENSSPAP00000028612	ENSSPAP00000019043	Uncharacterized protein.	RAP1A, member of RAS oncogene family a.	0.899

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Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.948

expected number of edges:

47

PPI enrichment p-value:

0.53

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

7 of 229

1.81

3.04

2.77e-08

GO:0010467

Gene expression

9 of 1738

1.04

1.14

4.44e-06

GO:0022618

Ribonucleoprotein complex assembly

3 of 155

1.61

0.8

0.0239

GO:0000387

Spliceosomal snRNP assembly

2 of 30

2.15

0.75

0.0415

GO:0034641

Cellular nitrogen compound metabolic process

9 of 3050

0.79

0.67

0.00044

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1990935

Splicing factor binding

2 of 4

3.02

1.34

0.0038

GO:0003723

RNA binding

8 of 1208

1.14

1.24

2.24e-05

GO:0003676

Nucleic acid binding

9 of 3699

0.71

0.53

0.0038

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005686

U2 snRNP

5 of 20

2.72

5.12

1.89e-10

GO:0071011

Precatalytic spliceosome

6 of 53

2.38

4.86

1.24e-10

GO:0005684

U2-type spliceosomal complex

6 of 92

2.14

4.22

5.76e-10

GO:0071005

U2-type precatalytic spliceosome

5 of 48

2.34

4.12

5.07e-09

GO:0005681

Spliceosomal complex

7 of 176

1.92

3.93

1.89e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18986

U2 snRNP, and Nuclear cap binding complex

6 of 23

2.74

5.91

5.02e-12

CL:18988

U2 snRNP

4 of 12

2.84

4.05

3.05e-08

CL:19002

Splicing factor binding, and PSP, proline-rich

3 of 5

3.1

3.14

1.97e-06

CL:19016

U4 snRNP

2 of 5

2.92

1.53

0.0017

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

7 of 266

1.74

3.21

1.84e-09

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72165

mRNA Splicing - Minor Pathway

6 of 59

2.33

4.64

2.98e-10

MAP-72172

mRNA Splicing

7 of 296

1.7

2.88

1.45e-08

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

7 of 391

1.57

2.48

5.54e-08

MAP-8953854

Metabolism of RNA

9 of 946

1.3

1.91

1.45e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990904

Ribonucleoprotein complex

9 of 447

1.63

3.22

3.44e-11

GOCC:0097525

Spliceosomal snRNP complex

4 of 40

2.32

2.85

2.87e-06

GOCC:0005681

Spliceosomal complex

4 of 107

1.89

2.04

4.99e-05

GOCC:0005687

U4 snRNP

2 of 6

2.84

1.63

0.0011

GOCC:0005689

U12-type spliceosomal complex

2 of 8

2.72

1.53

0.0016

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0687

Ribonucleoprotein

4 of 93

1.96

2.16

3.14e-05

KW-0694

RNA-binding

4 of 347

1.38

1.06

0.0027

KW-0689

Ribosomal protein

2 of 63

1.82

0.7

0.0469

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