node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
UBB | get3 | ENSSPAP00000003565 | ENSSPAP00000009209 | Ubiquitin B. | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.748 |
UBB | mysm1 | ENSSPAP00000003565 | ENSSPAP00000017862 | Ubiquitin B. | Myb-like, SWIRM and MPN domains 1. | 0.997 |
UBB | ngly1 | ENSSPAP00000003565 | ENSSPAP00000008535 | Ubiquitin B. | N-glycanase 1. | 0.886 |
UBB | psmc1 | ENSSPAP00000003565 | ENSSPAP00000008264 | Ubiquitin B. | Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. | 0.984 |
UBB | psmd14 | ENSSPAP00000003565 | ENSSPAP00000007064 | Ubiquitin B. | Proteasome 26S subunit, non-ATPase 14. | 0.995 |
UBB | psmd2 | ENSSPAP00000003565 | ENSSPAP00000004622 | Ubiquitin B. | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. | 0.985 |
UBB | rad23b | ENSSPAP00000003565 | ENSSPAP00000004252 | Ubiquitin B. | RAD23 homolog B, nucleotide excision repair protein. | 0.961 |
UBB | traf7 | ENSSPAP00000003565 | ENSSPAP00000020334 | Ubiquitin B. | TNF receptor-associated factor 7. | 0.960 |
UBB | trip12 | ENSSPAP00000003565 | ENSSPAP00000015155 | Ubiquitin B. | Thyroid hormone receptor interactor 12. | 0.973 |
UBB | xpc | ENSSPAP00000003565 | ENSSPAP00000013868 | Ubiquitin B. | Xeroderma pigmentosum, complementation group C. | 0.896 |
get3 | UBB | ENSSPAP00000009209 | ENSSPAP00000003565 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Ubiquitin B. | 0.748 |
get3 | mysm1 | ENSSPAP00000009209 | ENSSPAP00000017862 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Myb-like, SWIRM and MPN domains 1. | 0.568 |
get3 | psmd14 | ENSSPAP00000009209 | ENSSPAP00000007064 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | Proteasome 26S subunit, non-ATPase 14. | 0.786 |
get3 | rad23b | ENSSPAP00000009209 | ENSSPAP00000004252 | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | RAD23 homolog B, nucleotide excision repair protein. | 0.949 |
mysm1 | UBB | ENSSPAP00000017862 | ENSSPAP00000003565 | Myb-like, SWIRM and MPN domains 1. | Ubiquitin B. | 0.997 |
mysm1 | get3 | ENSSPAP00000017862 | ENSSPAP00000009209 | Myb-like, SWIRM and MPN domains 1. | ATPase ASNA1; ATPase required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. [...] | 0.568 |
mysm1 | psmc1 | ENSSPAP00000017862 | ENSSPAP00000008264 | Myb-like, SWIRM and MPN domains 1. | Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. | 0.992 |
mysm1 | psmd2 | ENSSPAP00000017862 | ENSSPAP00000004622 | Myb-like, SWIRM and MPN domains 1. | 26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. | 0.984 |
mysm1 | rad23b | ENSSPAP00000017862 | ENSSPAP00000004252 | Myb-like, SWIRM and MPN domains 1. | RAD23 homolog B, nucleotide excision repair protein. | 0.993 |
mysm1 | traf7 | ENSSPAP00000017862 | ENSSPAP00000020334 | Myb-like, SWIRM and MPN domains 1. | TNF receptor-associated factor 7. | 0.714 |