LOC103367455 protein (Stegastes partitus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LOC103367455

Regulator of G protein signaling 16. (189 aa)

Predicted Functional Partners:

GNB5

0.879

GNAZ

0.836

LOC103367853

0.824

LOC103360495

0.824

LOC103373424

0.808

LOC103367862

0.808

LOC103356208

0.808

LOC103374184

0.808

gnai1

0.808

LOC103373780

0.808

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNAZ	GNB5	ENSSPAP00000004230	ENSSPAP00000028993	G protein subunit alpha z.	G protein subunit beta 5.	0.879
GNAZ	LOC103356208	ENSSPAP00000004230	ENSSPAP00000010546	G protein subunit alpha z.	Guanine nucleotide binding protein (G protein) alpha v1.	0.500
GNAZ	LOC103360495	ENSSPAP00000004230	ENSSPAP00000026536	G protein subunit alpha z.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1.	0.436
GNAZ	LOC103367455	ENSSPAP00000004230	ENSSPAP00000004682	G protein subunit alpha z.	Regulator of G protein signaling 16.	0.836
GNAZ	LOC103367853	ENSSPAP00000004230	ENSSPAP00000006013	G protein subunit alpha z.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	0.437
GNAZ	LOC103367862	ENSSPAP00000004230	ENSSPAP00000006041	G protein subunit alpha z.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.486
GNAZ	LOC103373424	ENSSPAP00000004230	ENSSPAP00000005785	G protein subunit alpha z.	Uncharacterized protein.	0.507
GNAZ	LOC103373780	ENSSPAP00000004230	ENSSPAP00000023745	G protein subunit alpha z.	Uncharacterized protein.	0.486
GNAZ	LOC103374184	ENSSPAP00000004230	ENSSPAP00000013366	G protein subunit alpha z.	Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b.	0.490
GNAZ	gnai1	ENSSPAP00000004230	ENSSPAP00000017842	G protein subunit alpha z.	Uncharacterized protein.	0.486
GNB5	GNAZ	ENSSPAP00000028993	ENSSPAP00000004230	G protein subunit beta 5.	G protein subunit alpha z.	0.879
GNB5	LOC103356208	ENSSPAP00000028993	ENSSPAP00000010546	G protein subunit beta 5.	Guanine nucleotide binding protein (G protein) alpha v1.	0.855
GNB5	LOC103360495	ENSSPAP00000028993	ENSSPAP00000026536	G protein subunit beta 5.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1.	0.869
GNB5	LOC103367455	ENSSPAP00000028993	ENSSPAP00000004682	G protein subunit beta 5.	Regulator of G protein signaling 16.	0.879
GNB5	LOC103367853	ENSSPAP00000028993	ENSSPAP00000006013	G protein subunit beta 5.	Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2.	0.869
GNB5	LOC103367862	ENSSPAP00000028993	ENSSPAP00000006041	G protein subunit beta 5.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.855
GNB5	LOC103373424	ENSSPAP00000028993	ENSSPAP00000005785	G protein subunit beta 5.	Uncharacterized protein.	0.855
GNB5	LOC103373780	ENSSPAP00000028993	ENSSPAP00000023745	G protein subunit beta 5.	Uncharacterized protein.	0.855
GNB5	LOC103374184	ENSSPAP00000028993	ENSSPAP00000013366	G protein subunit beta 5.	Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b.	0.855
GNB5	gnai1	ENSSPAP00000028993	ENSSPAP00000017842	G protein subunit beta 5.	Uncharacterized protein.	0.855

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.782

expected number of edges:

11

PPI enrichment p-value:

0.000292

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006749

Glutathione metabolic process

3 of 47

2.11

1.09

0.0090

GO:0006534

Cysteine metabolic process

2 of 8

2.71

1.03

0.0133

GO:0009064

Glutamine family amino acid metabolic process

3 of 65

1.97

1.01

0.0117

GO:0006750

Glutathione biosynthetic process

2 of 10

2.61

1.01

0.0146

GO:1901605

Alpha-amino acid metabolic process

4 of 170

1.68

1.0

0.0090

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 44

2.14

1.28

0.0037

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005814

Centriole

3 of 108

1.75

0.83

0.0239

GO:0005813

Centrosome

4 of 413

1.29

0.71

0.0239

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:28614

Glutathione metabolism, and Oxidoreductase activity, acting on a sulfur group of donors

8 of 127

2.11

5.12

1.06e-12

CL:28680

Gamma-glutamyltranspeptidase, and Glutamate-cysteine ligase complex

3 of 7

2.94

2.75

9.75e-06

CL:28789

Mixed, incl. Metalloaminopeptidase activity, and Aspartate and asparagine metabolism

4 of 38

2.33

2.64

8.07e-06

CL:28620

Glutathione conjugation, and Glutathione peroxidase

4 of 39

2.32

2.63

8.07e-06

CL:28845

Negative regulation of cilium assembly, and Domain in ubiquitin-specific proteases.

3 of 10

2.79

2.57

1.94e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00480

Glutathione metabolism

5 of 126

1.91

2.78

5.66e-07

map00270

Cysteine and methionine metabolism

4 of 78

2.02

2.52

5.36e-06

map00250

Alanine, aspartate and glutamate metabolism

2 of 64

1.8

0.84

0.0229

map04216

Ferroptosis

2 of 74

1.74

0.82

0.0243

map01100

Metabolic pathways

9 of 3053

0.78

0.72

4.65e-05

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-174403

Glutathione synthesis and recycling

4 of 19

2.63

3.37

4.63e-07

MAP-156590

Glutathione conjugation

4 of 34

2.38

2.96

1.92e-06

MAP-156580

Phase II - Conjugation of compounds

4 of 95

1.93

2.02

6.44e-05

MAP-211859

Biological oxidations

4 of 254

1.51

1.17

0.0022

MAP-5620912

Anchoring of the basal body to the plasma membrane

3 of 105

1.76

1.11

0.0058

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0097721

Ciliary vesicle

2 of 4

3.01

1.32

0.0042

GOCC:0005814

Centriole

3 of 59

2.01

1.23

0.0042

GOCC:0005815

Microtubule organizing center

4 of 215

1.58

1.1

0.0042

GOCC:0005813

Centrosome

3 of 120

1.71

0.99

0.0098

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