pole4 protein (Stegastes partitus) - STRING interaction network

Nodes:

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

pole4

Polymerase (DNA-directed), epsilon 4, accessory subunit. (167 aa)

Predicted Functional Partners:

pole3

0.999

pole2

0.998

pole

0.998

pola1

0.933

pold1

0.901

ENSSPAP00000010489

0.878

ENSSPAP00000010503

0.878

cdc45

0.873

mcm5

0.822

rfc3

0.822

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000010489	ENSSPAP00000010503	ENSSPAP00000010489	ENSSPAP00000010503	Uncharacterized protein.	DNA_pol_B domain-containing protein.	0.900
ENSSPAP00000010489	cdc45	ENSSPAP00000010489	ENSSPAP00000001178	Uncharacterized protein.	CDC45 cell division cycle 45 homolog (S. cerevisiae).	0.952
ENSSPAP00000010489	mcm5	ENSSPAP00000010489	ENSSPAP00000004991	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.968
ENSSPAP00000010489	pola1	ENSSPAP00000010489	ENSSPAP00000020631	Uncharacterized protein.	DNA polymerase.	0.532
ENSSPAP00000010489	pold1	ENSSPAP00000010489	ENSSPAP00000012880	Uncharacterized protein.	DNA polymerase.	0.858
ENSSPAP00000010489	pole	ENSSPAP00000010489	ENSSPAP00000025346	Uncharacterized protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.766
ENSSPAP00000010489	pole2	ENSSPAP00000010489	ENSSPAP00000023534	Uncharacterized protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.975
ENSSPAP00000010489	pole3	ENSSPAP00000010489	ENSSPAP00000021121	Uncharacterized protein.	Polymerase (DNA directed), epsilon 3 (p17 subunit).	0.968
ENSSPAP00000010489	pole4	ENSSPAP00000010489	ENSSPAP00000021976	Uncharacterized protein.	Polymerase (DNA-directed), epsilon 4, accessory subunit.	0.878
ENSSPAP00000010489	rfc3	ENSSPAP00000010489	ENSSPAP00000015957	Uncharacterized protein.	Replication factor C (activator 1) 3.	0.815
ENSSPAP00000010503	ENSSPAP00000010489	ENSSPAP00000010503	ENSSPAP00000010489	DNA_pol_B domain-containing protein.	Uncharacterized protein.	0.900
ENSSPAP00000010503	cdc45	ENSSPAP00000010503	ENSSPAP00000001178	DNA_pol_B domain-containing protein.	CDC45 cell division cycle 45 homolog (S. cerevisiae).	0.952
ENSSPAP00000010503	mcm5	ENSSPAP00000010503	ENSSPAP00000004991	DNA_pol_B domain-containing protein.	DNA helicase; Belongs to the MCM family.	0.968
ENSSPAP00000010503	pola1	ENSSPAP00000010503	ENSSPAP00000020631	DNA_pol_B domain-containing protein.	DNA polymerase.	0.532
ENSSPAP00000010503	pold1	ENSSPAP00000010503	ENSSPAP00000012880	DNA_pol_B domain-containing protein.	DNA polymerase.	0.837
ENSSPAP00000010503	pole	ENSSPAP00000010503	ENSSPAP00000025346	DNA_pol_B domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.844
ENSSPAP00000010503	pole2	ENSSPAP00000010503	ENSSPAP00000023534	DNA_pol_B domain-containing protein.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.983
ENSSPAP00000010503	pole3	ENSSPAP00000010503	ENSSPAP00000021121	DNA_pol_B domain-containing protein.	Polymerase (DNA directed), epsilon 3 (p17 subunit).	0.968
ENSSPAP00000010503	pole4	ENSSPAP00000010503	ENSSPAP00000021976	DNA_pol_B domain-containing protein.	Polymerase (DNA-directed), epsilon 4, accessory subunit.	0.878
ENSSPAP00000010503	rfc3	ENSSPAP00000010503	ENSSPAP00000015957	DNA_pol_B domain-containing protein.	Replication factor C (activator 1) 3.	0.815

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.91

expected number of edges:

11

PPI enrichment p-value:

4.18e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009401

Phosphoenolpyruvate-dependent sugar phosphotransferase system

4 of 5

2.73

3.42

4.23e-07

GO:0006289

Nucleotide-excision repair

3 of 11

2.26

1.98

0.00016

GO:0009432

SOS response

3 of 19

2.02

1.66

0.00052

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009381

Excinuclease ABC activity

3 of 10

2.3

1.76

0.00048

GO:0008965

Phosphoenolpyruvate-protein phosphotransferase activity

2 of 2

2.82

1.53

0.0017

GO:0004518

Nuclease activity

4 of 61

1.64

1.48

0.00048

GO:0016887

ATP hydrolysis activity

3 of 61

1.52

0.94

0.0096

GO:0140640

Catalytic activity, acting on a nucleic acid

4 of 245

1.04

0.6

0.0266

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009380

Excinuclease repair complex

3 of 10

2.3

2.11

9.25e-05

GO:0005737

Cytoplasm

8 of 1249

0.63

0.49

0.0024

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:18485189

(2008) Unraveling the evolutionary history of the phosphoryl-transfer chain of the phosphoenolpyruvate:phosphotransferase system through phylogenetic analyses and genome context.

5 of 6

2.74

5.21

1.31e-10

PMID:26257709

(2015) The reduced genomes of Parcubacteria (OD1) contain signatures of a symbiotic lifestyle.

3 of 24

1.92

1.68

0.00039

PMID:15886391

(2005) An SOS-regulated operon involved in damage-inducible mutagenesis in Caulobacter crescentus.

2 of 5

2.43

1.51

0.0016

PMID:23902135

(2013) GTAG- and CGTC-tagged palindromic DNA repeats in prokaryotes.

2 of 6

2.35

1.5

0.0016

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9636

Mixed, incl. Import across plasma membrane, and Mannoside phosphorylase

5 of 17

2.29

3.7

3.41e-08

CL:9655

Import across plasma membrane, and Type I phosphodiesterase / nucleotide pyrophosphatase

4 of 6

2.65

3.6

1.72e-07

CL:9634

Mostly uncharacterized, incl. Import across plasma membrane, and Glycosyl hydrolase, five-bladed beta-propellor domain superfamily

6 of 39

2.01

3.41

2.56e-08

CL:915

DNA excision

3 of 6

2.52

2.29

5.26e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rba02060

Phosphotransferase system (PTS)

4 of 5

2.73

3.97

3.71e-08

rba03420

Nucleotide excision repair

3 of 12

2.22

2.17

6.10e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009380

Excinuclease repair complex

3 of 10

2.3

1.97

0.00018

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0267

Excision nuclease

3 of 5

2.6

2.43

3.02e-05

KW-0228

DNA excision

3 of 5

2.6

2.43

3.02e-05

KW-0598

Phosphotransferase system

2 of 2

2.82

1.83

0.00046

KW-0762

Sugar transport

2 of 3

2.65

1.75

0.00063

KW-0670

Pyruvate

2 of 13

2.01

1.17

0.0057

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF05524

PEP-utilising enzyme, N-terminal

2 of 2

2.82

1.16

0.0079

PF02896

PEP-utilising enzyme, PEP-binding domain

2 of 3

2.65

1.16

0.0079

PF00391

PEP-utilising enzyme, mobile domain

2 of 3

2.65

1.16

0.0079

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR041102

UvrA, interaction domain

2 of 3

2.65

0.95

0.0192

IPR036637

Phosphohistidine domain superfamily

2 of 3

2.65

0.95

0.0192

IPR036618

PtsI, HPr-binding domain superfamily

2 of 2

2.82

0.95

0.0192

IPR024692

Phosphotransferase system, enzyme I

2 of 2

2.82

0.95

0.0192

IPR023151

PEP-utilising enzyme, conserved site

2 of 3

2.65

0.95

0.0192

(more ...)

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