tada2a protein (Stegastes partitus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

tada2a

Transcriptional adaptor 2A. (380 aa)

Predicted Functional Partners:

tada3

0.998

sgf29

0.997

LOC103367729

0.991

trrap

0.991

supt3h

0.986

taf10

0.985

kat2a

0.982

taf12

0.982

kat2b

0.982

supt20h

0.977

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103367729	kat2a	ENSSPAP00000005694	ENSSPAP00000008492	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	K(lysine) acetyltransferase 2A.	0.980
LOC103367729	kat2b	ENSSPAP00000005694	ENSSPAP00000020875	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.980
LOC103367729	sgf29	ENSSPAP00000005694	ENSSPAP00000025138	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	SAGA complex associated factor 29.	0.997
LOC103367729	supt20h	ENSSPAP00000005694	ENSSPAP00000004521	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	SPT20 homolog, SAGA complex component.	0.989
LOC103367729	supt3h	ENSSPAP00000005694	ENSSPAP00000030900	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	SPT3 homolog, SAGA and STAGA complex component.	0.997
LOC103367729	tada2a	ENSSPAP00000005694	ENSSPAP00000022814	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Transcriptional adaptor 2A.	0.991
LOC103367729	tada3	ENSSPAP00000005694	ENSSPAP00000027872	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Transcriptional adaptor 3 (NGG1 homolog, yeast)-like.	0.999
LOC103367729	taf10	ENSSPAP00000005694	ENSSPAP00000027589	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.999
LOC103367729	taf12	ENSSPAP00000005694	ENSSPAP00000017191	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.999
LOC103367729	trrap	ENSSPAP00000005694	ENSSPAP00000013920	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family.	0.999
kat2a	LOC103367729	ENSSPAP00000008492	ENSSPAP00000005694	K(lysine) acetyltransferase 2A.	TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.980
kat2a	kat2b	ENSSPAP00000008492	ENSSPAP00000020875	K(lysine) acetyltransferase 2A.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.898
kat2a	sgf29	ENSSPAP00000008492	ENSSPAP00000025138	K(lysine) acetyltransferase 2A.	SAGA complex associated factor 29.	0.977
kat2a	supt20h	ENSSPAP00000008492	ENSSPAP00000004521	K(lysine) acetyltransferase 2A.	SPT20 homolog, SAGA complex component.	0.950
kat2a	supt3h	ENSSPAP00000008492	ENSSPAP00000030900	K(lysine) acetyltransferase 2A.	SPT3 homolog, SAGA and STAGA complex component.	0.974
kat2a	tada2a	ENSSPAP00000008492	ENSSPAP00000022814	K(lysine) acetyltransferase 2A.	Transcriptional adaptor 2A.	0.982
kat2a	tada3	ENSSPAP00000008492	ENSSPAP00000027872	K(lysine) acetyltransferase 2A.	Transcriptional adaptor 3 (NGG1 homolog, yeast)-like.	0.985
kat2a	taf10	ENSSPAP00000008492	ENSSPAP00000027589	K(lysine) acetyltransferase 2A.	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.985
kat2a	taf12	ENSSPAP00000008492	ENSSPAP00000017191	K(lysine) acetyltransferase 2A.	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor.	0.965
kat2a	trrap	ENSSPAP00000008492	ENSSPAP00000013920	K(lysine) acetyltransferase 2A.	Transformation/transcription domain-associated protein; Belongs to the PI3/PI4-kinase family.	0.985

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.982

expected number of edges:

17

PPI enrichment p-value:

3.4e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098609

Cell-cell adhesion

5 of 435

1.54

1.27

0.0013

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045294

Alpha-catenin binding

2 of 10

2.78

0.97

0.0174

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0014704

Intercalated disc

2 of 11

2.74

1.28

0.0048

GO:0005911

Cell-cell junction

4 of 317

1.58

1.15

0.0032

GO:0016342

Catenin complex

2 of 30

2.31

0.98

0.0154

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:37965

Cadherin-like superfamily, and Plakophilin/Delta catenin

5 of 97

2.2

3.1

5.32e-07

CL:38071

Mixed, incl. Limb expression 1, and Retina layer formation

3 of 11

2.92

2.95

3.94e-06

CL:6049

RHOU GTPase cycle, and Unconventional class IX myosin

3 of 14

2.81

2.83

6.30e-06

CL:37972

Cadherin-like superfamily, and Plakophilin/Delta catenin

4 of 85

2.16

2.61

5.75e-06

CL:38074

Limb expression 1, and Retina layer formation

2 of 5

3.09

1.87

0.00042

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04392

Hippo signaling pathway - multiple species

3 of 102

1.95

1.51

0.00098

map04520

Adherens junction

3 of 115

1.9

1.49

0.00098

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9013026

RHOB GTPase cycle

3 of 71

2.11

1.35

0.0027

MAP-8980692

RHOA GTPase cycle

3 of 178

1.71

0.86

0.0199

MAP-5218920

VEGFR2 mediated vascular permeability

2 of 35

2.24

0.79

0.0347

MAP-418990

Adherens junctions interactions

2 of 40

2.18

0.79

0.0347

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005911

Cell-cell junction

4 of 224

1.74

1.42

0.0010

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0518

Myosin

2 of 56

2.04

0.7

0.0499

KW-0106

Calcium

3 of 368

1.39

0.62

0.0499

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046987

Unconventional class IX myosin

3 of 4

3.36

2.87

6.62e-06

IPR036023

Class IX myosin, motor domain

2 of 2

3.48

1.49

0.0021

IPR013284

Beta-catenin

2 of 3

3.31

1.47

0.0023

IPR020894

Cadherin conserved site

3 of 107

1.93

1.04

0.0100

IPR015919

Cadherin-like superfamily

3 of 122

1.87

0.99

0.0118

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00112

Cadherin repeats.

3 of 118

1.89

1.14

0.0057

SM00314

Ras association (RalGDS/AF-6) domain

2 of 30

2.31

0.94

0.0187

SM00185

Armadillo/beta-catenin-like repeats

2 of 32

2.28

0.94

0.0187

SM00242

Myosin. Large ATPases.

2 of 38

2.2

0.93

0.0187

SM00282

Laminin G domain

2 of 50

2.09

0.91

0.0199

(more ...)

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