LOC103355409 protein (Stegastes partitus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

LOC103355409

Uncharacterized protein. (141 aa)

Predicted Functional Partners:

ENSSPAP00000018958

0.503

LOC103356287

0.478

LOC103375440

0.473

LOC103358892

0.433

mfap3

0.427

ENSSPAP00000027178

0.417

ENSSPAP00000020459

0.408

LOC103374165

0.404

ENSSPAP00000015532

0.403

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000015532	ENSSPAP00000020459	ENSSPAP00000015532	ENSSPAP00000020459	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Fibronectin type-III domain-containing protein.	0.486
ENSSPAP00000015532	ENSSPAP00000027178	ENSSPAP00000015532	ENSSPAP00000027178	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Melanocortin 4 receptor.	0.463
ENSSPAP00000015532	LOC103355409	ENSSPAP00000015532	ENSSPAP00000025240	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Uncharacterized protein.	0.403
ENSSPAP00000015532	LOC103356287	ENSSPAP00000015532	ENSSPAP00000003398	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Protein S100; Belongs to the S-100 family.	0.503
ENSSPAP00000015532	LOC103374165	ENSSPAP00000015532	ENSSPAP00000012837	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Bone morphogenetic protein/retinoic acid inducible neural-specific 2.	0.494
ENSSPAP00000015532	LOC103375440	ENSSPAP00000015532	ENSSPAP00000018365	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Protein S100; Belongs to the S-100 family.	0.475
ENSSPAP00000015532	mfap3	ENSSPAP00000015532	ENSSPAP00000010271	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Microfibril associated protein 3.	0.430
ENSSPAP00000018958	ENSSPAP00000020459	ENSSPAP00000018958	ENSSPAP00000020459	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Fibronectin type-III domain-containing protein.	0.456
ENSSPAP00000018958	ENSSPAP00000027178	ENSSPAP00000018958	ENSSPAP00000027178	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Melanocortin 4 receptor.	0.468
ENSSPAP00000018958	LOC103355409	ENSSPAP00000018958	ENSSPAP00000025240	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Uncharacterized protein.	0.503
ENSSPAP00000018958	LOC103356287	ENSSPAP00000018958	ENSSPAP00000003398	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Protein S100; Belongs to the S-100 family.	0.491
ENSSPAP00000018958	LOC103374165	ENSSPAP00000018958	ENSSPAP00000012837	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Bone morphogenetic protein/retinoic acid inducible neural-specific 2.	0.498
ENSSPAP00000018958	LOC103375440	ENSSPAP00000018958	ENSSPAP00000018365	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Protein S100; Belongs to the S-100 family.	0.473
ENSSPAP00000018958	mfap3	ENSSPAP00000018958	ENSSPAP00000010271	Neurexophilin; May be signaling molecules that resemble neuropeptides.	Microfibril associated protein 3.	0.473
ENSSPAP00000020459	ENSSPAP00000015532	ENSSPAP00000020459	ENSSPAP00000015532	Fibronectin type-III domain-containing protein.	Neurexophilin; May be signaling molecules that resemble neuropeptides.	0.486
ENSSPAP00000020459	ENSSPAP00000018958	ENSSPAP00000020459	ENSSPAP00000018958	Fibronectin type-III domain-containing protein.	Neurexophilin; May be signaling molecules that resemble neuropeptides.	0.456
ENSSPAP00000020459	LOC103355409	ENSSPAP00000020459	ENSSPAP00000025240	Fibronectin type-III domain-containing protein.	Uncharacterized protein.	0.408
ENSSPAP00000020459	LOC103356287	ENSSPAP00000020459	ENSSPAP00000003398	Fibronectin type-III domain-containing protein.	Protein S100; Belongs to the S-100 family.	0.607
ENSSPAP00000020459	LOC103358892	ENSSPAP00000020459	ENSSPAP00000005575	Fibronectin type-III domain-containing protein.	Neurexophilin; May be signaling molecules that resemble neuropeptides.	0.446
ENSSPAP00000020459	LOC103374165	ENSSPAP00000020459	ENSSPAP00000012837	Fibronectin type-III domain-containing protein.	Bone morphogenetic protein/retinoic acid inducible neural-specific 2.	0.418

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.824

expected number of edges:

59

PPI enrichment p-value:

0.999

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035721

Intraciliary retrograde transport

4 of 9

2.96

4.04

3.64e-08

GO:0060271

Cilium assembly

8 of 289

1.75

3.28

1.13e-09

GO:0061512

Protein localization to cilium

4 of 32

2.41

3.02

1.49e-06

GO:0099111

Microtubule-based transport

5 of 133

1.88

2.52

2.50e-06

GO:0036158

Outer dynein arm assembly

3 of 14

2.64

2.41

3.45e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030991

Intraciliary transport particle A

4 of 5

3.21

4.56

5.00e-09

GO:0005929

Cilium

7 of 519

1.44

2.01

4.85e-07

GO:0120293

Dynein axonemal particle

2 of 15

2.43

1.26

0.0047

GO:0005930

Axoneme

3 of 110

1.74

1.16

0.0042

GO:0036064

Ciliary basal body

3 of 127

1.68

1.12

0.0047

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7847

Intraciliary transport particle A

4 of 5

3.21

4.25

1.83e-08

CL:9966

Mixed, incl. Inner dynein arm assembly, and Radial spokehead-like protein

4 of 16

2.71

3.46

3.51e-07

CL:9970

Radial spokehead-like protein, and Inner dynein arm assembly

3 of 6

3.01

2.95

4.14e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5620924

Intraflagellar transport

4 of 53

2.19

2.38

2.05e-05

MAP-5617833

Cilium Assembly

4 of 244

1.52

1.09

0.0038

MAP-1852241

Organelle biogenesis and maintenance

4 of 302

1.43

0.98

0.0058

MAP-5610787

Hedgehog off state

3 of 130

1.67

0.92

0.0136

MAP-5358351

Signaling by Hedgehog

3 of 187

1.51

0.73

0.0315

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030991

Intraciliary transport particle A

4 of 4

3.31

4.67

3.35e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0969

Cilium

3 of 16

2.58

2.43

2.95e-05

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