slitrk2 protein (Stegastes partitus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

slitrk2

SLIT and NTRK-like family, member 2. (852 aa)

Predicted Functional Partners:

ENSSPAP00000007341

0.783

ENSSPAP00000008357

0.783

ENSSPAP00000005052

0.780

ENSSPAP00000005690

0.780

LOC103362234

0.780

ENSSPAP00000016882

0.780

ENSSPAP00000016914

0.780

LOC103364114

0.780

adgrl1

0.780

LOC103353172

0.780

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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... protein annotations:

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000005052	ENSSPAP00000005690	ENSSPAP00000005052	ENSSPAP00000005690	SUEL-type lectin domain-containing protein.	Olfactomedin-like domain-containing protein.	0.556
ENSSPAP00000005052	slitrk2	ENSSPAP00000005052	ENSSPAP00000026264	SUEL-type lectin domain-containing protein.	SLIT and NTRK-like family, member 2.	0.780
ENSSPAP00000005690	ENSSPAP00000005052	ENSSPAP00000005690	ENSSPAP00000005052	Olfactomedin-like domain-containing protein.	SUEL-type lectin domain-containing protein.	0.556
ENSSPAP00000005690	ENSSPAP00000016882	ENSSPAP00000005690	ENSSPAP00000016882	Olfactomedin-like domain-containing protein.	Latrophilin domain-containing protein.	0.663
ENSSPAP00000005690	ENSSPAP00000016914	ENSSPAP00000005690	ENSSPAP00000016914	Olfactomedin-like domain-containing protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.916
ENSSPAP00000005690	slitrk2	ENSSPAP00000005690	ENSSPAP00000026264	Olfactomedin-like domain-containing protein.	SLIT and NTRK-like family, member 2.	0.780
ENSSPAP00000007341	ENSSPAP00000008357	ENSSPAP00000007341	ENSSPAP00000008357	Netrin g1a.	Vav 3 guanine nucleotide exchange factor b.	0.648
ENSSPAP00000007341	slitrk2	ENSSPAP00000007341	ENSSPAP00000026264	Netrin g1a.	SLIT and NTRK-like family, member 2.	0.783
ENSSPAP00000008357	ENSSPAP00000007341	ENSSPAP00000008357	ENSSPAP00000007341	Vav 3 guanine nucleotide exchange factor b.	Netrin g1a.	0.648
ENSSPAP00000008357	slitrk2	ENSSPAP00000008357	ENSSPAP00000026264	Vav 3 guanine nucleotide exchange factor b.	SLIT and NTRK-like family, member 2.	0.783
ENSSPAP00000016882	ENSSPAP00000005690	ENSSPAP00000016882	ENSSPAP00000005690	Latrophilin domain-containing protein.	Olfactomedin-like domain-containing protein.	0.663
ENSSPAP00000016882	ENSSPAP00000016914	ENSSPAP00000016882	ENSSPAP00000016914	Latrophilin domain-containing protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.703
ENSSPAP00000016882	LOC103362234	ENSSPAP00000016882	ENSSPAP00000008800	Latrophilin domain-containing protein.	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	0.779
ENSSPAP00000016882	slitrk2	ENSSPAP00000016882	ENSSPAP00000026264	Latrophilin domain-containing protein.	SLIT and NTRK-like family, member 2.	0.780
ENSSPAP00000016914	ENSSPAP00000005690	ENSSPAP00000016914	ENSSPAP00000005690	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Olfactomedin-like domain-containing protein.	0.916
ENSSPAP00000016914	ENSSPAP00000016882	ENSSPAP00000016914	ENSSPAP00000016882	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Latrophilin domain-containing protein.	0.703
ENSSPAP00000016914	slitrk2	ENSSPAP00000016914	ENSSPAP00000026264	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	SLIT and NTRK-like family, member 2.	0.780
LOC103353172	slitrk2	ENSSPAP00000024723	ENSSPAP00000026264	Adhesion G protein-coupled receptor L3.1; Belongs to the G-protein coupled receptor 2 family.	SLIT and NTRK-like family, member 2.	0.780
LOC103362234	ENSSPAP00000016882	ENSSPAP00000008800	ENSSPAP00000016882	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Latrophilin domain-containing protein.	0.779
LOC103362234	slitrk2	ENSSPAP00000008800	ENSSPAP00000026264	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	SLIT and NTRK-like family, member 2.	0.780

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

47

average node degree:

8.55

avg. local clustering coefficient:

0.894

expected number of edges:

11

PPI enrichment p-value:

2.22e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090151

Establishment of protein localization to mitochondrial membrane

5 of 33

2.09

3.04

4.29e-07

GO:0072655

Establishment of protein localization to mitochondrion

6 of 58

1.92

2.99

1.71e-07

GO:0006839

Mitochondrial transport

6 of 59

1.92

2.97

1.71e-07

GO:0051205

Protein insertion into membrane

5 of 45

1.95

2.72

1.20e-06

GO:0006626

Protein targeting to mitochondrion

5 of 49

1.92

2.64

1.53e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030943

Mitochondrion targeting sequence binding

2 of 4

2.61

0.83

0.0307

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032592

Integral component of mitochondrial membrane

6 of 48

2.0

3.49

1.42e-08

GO:0005741

Mitochondrial outer membrane

6 of 54

1.95

3.41

1.42e-08

GO:0031307

Integral component of mitochondrial outer membrane

4 of 14

2.36

3.21

5.35e-07

GO:0031966

Mitochondrial membrane

7 of 306

1.27

1.6

1.52e-06

GO:0000127

Transcription factor TFIIIC complex

2 of 4

2.61

1.59

0.0012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9394

Protein localization to mitochondrion, and Mitochondrial calcium ion transport

5 of 41

1.99

2.66

2.14e-06

CL:9397

Protein import into mitochondrial matrix, and Tim10-like

3 of 22

2.04

1.57

0.00085

CL:9426

Mitochondrial outer membrane translocase complex

2 of 5

2.51

1.19

0.0067

CL:1471

Transcription factor TFIIIC complex

2 of 5

2.51

1.19

0.0067

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031307

Integral component of mitochondrial outer membrane

4 of 11

2.47

3.41

2.79e-07

GOCC:0032592

Integral component of mitochondrial membrane

5 of 33

2.09

3.18

1.90e-07

GOCC:0005741

Mitochondrial outer membrane

6 of 74

1.82

2.81

1.90e-07

GOCC:0031966

Mitochondrial membrane

7 of 241

1.37

1.88

4.38e-07

GOCC:0005742

Mitochondrial outer membrane translocase complex

2 of 5

2.51

1.53

0.0015

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