sh3glb2 protein (Stegastes partitus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

sh3glb2

Uncharacterized protein. (382 aa)

Predicted Functional Partners:

uvrag

0.905

sh3kbp1

0.862

LOC103367561

0.821

LOC103369338

0.821

LOC103358795

0.805

usp14

0.716

sh3d21

0.704

cd2ap

0.704

LOC103369640

0.685

atg9b

0.671

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103358795	LOC103367561	ENSSPAP00000001124	ENSSPAP00000024033	SH3-domain GRB2-like 1b.	Protein kinase domain-containing protein.	0.884
LOC103358795	LOC103369338	ENSSPAP00000001124	ENSSPAP00000024604	SH3-domain GRB2-like 1b.	Receptor protein-tyrosine kinase.	0.884
LOC103358795	LOC103369640	ENSSPAP00000001124	ENSSPAP00000015940	SH3-domain GRB2-like 1b.	SH3 domain containing GRB2 like 2a, endophilin A1.	0.804
LOC103358795	cd2ap	ENSSPAP00000001124	ENSSPAP00000027869	SH3-domain GRB2-like 1b.	CD2-associated protein.	0.697
LOC103358795	sh3d21	ENSSPAP00000001124	ENSSPAP00000023427	SH3-domain GRB2-like 1b.	SH3 domain containing 21.	0.697
LOC103358795	sh3glb2	ENSSPAP00000001124	ENSSPAP00000028214	SH3-domain GRB2-like 1b.	Uncharacterized protein.	0.805
LOC103358795	sh3kbp1	ENSSPAP00000001124	ENSSPAP00000019419	SH3-domain GRB2-like 1b.	SH3-domain kinase binding protein 1.	0.895
LOC103367561	LOC103358795	ENSSPAP00000024033	ENSSPAP00000001124	Protein kinase domain-containing protein.	SH3-domain GRB2-like 1b.	0.884
LOC103367561	LOC103369338	ENSSPAP00000024033	ENSSPAP00000024604	Protein kinase domain-containing protein.	Receptor protein-tyrosine kinase.	0.833
LOC103367561	LOC103369640	ENSSPAP00000024033	ENSSPAP00000015940	Protein kinase domain-containing protein.	SH3 domain containing GRB2 like 2a, endophilin A1.	0.884
LOC103367561	cd2ap	ENSSPAP00000024033	ENSSPAP00000027869	Protein kinase domain-containing protein.	CD2-associated protein.	0.665
LOC103367561	sh3d21	ENSSPAP00000024033	ENSSPAP00000023427	Protein kinase domain-containing protein.	SH3 domain containing 21.	0.665
LOC103367561	sh3glb2	ENSSPAP00000024033	ENSSPAP00000028214	Protein kinase domain-containing protein.	Uncharacterized protein.	0.821
LOC103367561	sh3kbp1	ENSSPAP00000024033	ENSSPAP00000019419	Protein kinase domain-containing protein.	SH3-domain kinase binding protein 1.	0.892
LOC103369338	LOC103358795	ENSSPAP00000024604	ENSSPAP00000001124	Receptor protein-tyrosine kinase.	SH3-domain GRB2-like 1b.	0.884
LOC103369338	LOC103367561	ENSSPAP00000024604	ENSSPAP00000024033	Receptor protein-tyrosine kinase.	Protein kinase domain-containing protein.	0.833
LOC103369338	LOC103369640	ENSSPAP00000024604	ENSSPAP00000015940	Receptor protein-tyrosine kinase.	SH3 domain containing GRB2 like 2a, endophilin A1.	0.884
LOC103369338	cd2ap	ENSSPAP00000024604	ENSSPAP00000027869	Receptor protein-tyrosine kinase.	CD2-associated protein.	0.665
LOC103369338	sh3d21	ENSSPAP00000024604	ENSSPAP00000023427	Receptor protein-tyrosine kinase.	SH3 domain containing 21.	0.665
LOC103369338	sh3glb2	ENSSPAP00000024604	ENSSPAP00000028214	Receptor protein-tyrosine kinase.	Uncharacterized protein.	0.821

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.895

expected number of edges:

11

PPI enrichment p-value:

1.9e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 100

1.34

2.22

1.96e-10

GO:0009059

Macromolecule biosynthetic process

11 of 164

1.17

1.72

1.96e-10

GO:0010467

Gene expression

11 of 187

1.11

1.57

1.96e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 244

1.0

1.26

1.51e-09

GO:0044238

Primary metabolic process

11 of 736

0.52

0.45

0.00011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 55

1.6

3.41

7.00e-13

GO:0019843

rRNA binding

8 of 41

1.64

3.03

5.68e-10

GO:0003723

RNA binding

9 of 99

1.3

1.97

4.42e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.34

1.08

0.0103

GO:0000049

tRNA binding

3 of 24

1.44

0.83

0.0156

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 57

1.59

3.45

1.16e-13

GO:0044391

Ribosomal subunit

4 of 14

1.8

2.22

9.87e-06

GO:0015934

Large ribosomal subunit

3 of 8

1.92

1.89

0.00012

GO:0032991

Protein-containing complex

5 of 143

0.89

0.69

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27330141

(2016) Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity.

7 of 26

1.78

2.96

3.35e-08

PMID:28977619

(2017) The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression.

8 of 51

1.54

2.45

3.35e-08

PMID:22043294

(2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

4 of 8

2.04

1.98

0.00011

PMID:20019804

(2009) Transcriptome and proteome exploration to model translation efficiency and protein stability in Lactococcus lactis.

6 of 65

1.31

1.32

0.00015

PMID:30779773

(2019) Multiplexing polysome profiling experiments to study translation in Escherichia coli.

3 of 7

1.98

1.24

0.0040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95

rRNA-binding

8 of 31

1.76

3.73

1.37e-11

CL:86

Ribosome, and Translational elongation

11 of 69

1.55

3.38

1.30e-14

CL:89

Ribosome

10 of 59

1.57

3.36

2.01e-13

CL:91

Ribosome

9 of 50

1.6

3.28

4.05e-12

CL:147

Large ribosomal subunit rRNA binding, and Translation regulation

4 of 5

2.25

3.03

9.25e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

llm03010

Ribosome

10 of 55

1.6

3.53

9.24e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015934

Large ribosomal subunit

5 of 10

2.04

3.23

1.01e-07

GOCC:0005840

Ribosome

8 of 45

1.59

2.87

9.60e-10

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 6

2.04

1.94

0.00013

GOCC:0043229

Intracellular organelle

10 of 224

0.99

1.19

5.88e-08

GOCC:0032991

Protein-containing complex

6 of 331

0.6

0.38

0.0297

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.6

3.45

2.01e-13

KW-0699

rRNA-binding

8 of 39

1.66

3.24

9.68e-11

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (24%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About