ENSSPAP00000029079 protein (Stegastes partitus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSSPAP00000029079

Zgc:110182. (267 aa)

Predicted Functional Partners:

urod

0.535

vwa5b2

0.416

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

Network Stats

number of nodes:

11

number of edges:

14

average node degree:

2.55

avg. local clustering coefficient:

0.917

expected number of edges:

11

PPI enrichment p-value:

0.216

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007186

G protein-coupled receptor signaling pathway

11 of 846

1.39

2.54

3.95e-12

GO:0007188

Adenylate cyclase-modulating G protein-coupled receptor signaling pathway

5 of 259

1.57

1.55

0.00021

GO:0007189

Adenylate cyclase-activating G protein-coupled receptor signaling pathway

4 of 146

1.72

1.43

0.00091

GO:0045987

Positive regulation of smooth muscle contraction

2 of 8

2.68

1.21

0.0064

GO:0007204

Positive regulation of cytosolic calcium ion concentration

3 of 80

1.85

1.12

0.0063

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045125

Bioactive lipid receptor activity

3 of 12

2.68

2.24

7.50e-05

GO:0001664

G protein-coupled receptor binding

5 of 189

1.7

1.82

7.50e-05

GO:0070915

Lysophosphatidic acid receptor activity

2 of 4

2.98

1.44

0.0025

GO:0038036

sphingosine-1-phosphate receptor activity

2 of 9

2.63

1.25

0.0052

GO:0004930

G protein-coupled receptor activity

6 of 631

1.26

1.21

0.00027

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7085

Mixed, incl. ARHGEF1-like, PH domain, and D5 dopamine receptor binding

4 of 14

2.74

3.37

5.41e-07

CL:7102

Regulator of G protein signalling-like domain, and D5 dopamine receptor binding

3 of 5

3.06

2.78

8.69e-06

CL:32429

Amine ligand-binding receptors, and GTPase complex

5 of 151

1.8

2.21

1.03e-05

CL:32430

Amine ligand-binding receptors, and GTPase complex

4 of 137

1.75

1.61

0.00034

CL:32689

Sphingosine 1-phosphate receptor

2 of 7

2.74

1.34

0.0036

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04810

Regulation of actin cytoskeleton

6 of 318

1.56

2.16

1.08e-06

map04270

Vascular smooth muscle contraction

4 of 206

1.57

1.56

0.00020

map04080

Neuroactive ligand-receptor interaction

6 of 623

1.26

1.4

2.79e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-416482

G alpha (12/13) signalling events

6 of 114

2.0

3.58

7.66e-09

MAP-372790

Signaling by GPCR

11 of 913

1.36

2.45

1.87e-12

MAP-419408

Lysosphingolipid and LPA receptors

3 of 21

2.44

2.28

5.10e-05

MAP-388396

GPCR downstream signalling

10 of 861

1.35

2.24

1.26e-10

MAP-500792

GPCR ligand binding

7 of 570

1.37

1.8

1.42e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0807

Transducer

6 of 426

1.43

1.73

9.90e-06

KW-0297

G-protein coupled receptor

4 of 368

1.32

0.95

0.0046

KW-0344

Guanine-nucleotide releasing factor

2 of 66

1.76

0.7

0.0437

KW-0675

Receptor

5 of 1211

0.9

0.54

0.0237

KW-0472

Membrane

8 of 4710

0.51

0.32

0.0437

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF09128

Regulator of G protein signalling-like domain

2 of 2

3.28

1.54

0.0017

PF00001

7 transmembrane receptor (rhodopsin family)

5 of 330

1.46

1.25

0.00098

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015212

Regulator of G protein signalling-like domain

3 of 3

3.28

2.68

1.45e-05

IPR041020

ARHGEF1-like, PH domain

3 of 8

2.85

2.31

5.96e-05

IPR000276

G protein-coupled receptor, rhodopsin-like

6 of 403

1.45

1.59

5.96e-05

IPR017452

GPCR, rhodopsin-like, 7TM

6 of 405

1.45

1.58

5.96e-05

IPR044926

RGS, subdomain 2

3 of 49

2.07

1.3

0.0032

(more ...)

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node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000029079	urod	ENSSPAP00000029079	ENSSPAP00000002912	Zgc:110182.	Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family.	0.535
ENSSPAP00000029079	vwa5b2	ENSSPAP00000029079	ENSSPAP00000020639	Zgc:110182.	Von Willebrand factor A domain containing 5B2.	0.416
urod	ENSSPAP00000029079	ENSSPAP00000002912	ENSSPAP00000029079	Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family.	Zgc:110182.	0.535
vwa5b2	ENSSPAP00000029079	ENSSPAP00000020639	ENSSPAP00000029079	Von Willebrand factor A domain containing 5B2.	Zgc:110182.	0.416

Network

Cooccurrence

Experiments

Neighborhood

Textmining

Fusion

Databases

Coexpression

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