ENSSPAP00000029132 protein (Stegastes partitus)

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

ENSSPAP00000029132

RRM domain-containing protein. (96 aa)

Predicted Functional Partners:

nxf1

0.948

ncbp2

0.941

srpk1

0.926

LOC103370233

0.926

LOC103363951

0.900

srsf2

0.897

NCBP1

0.882

LOC103366532

0.882

ALYREF

0.879

cdc5l

0.876

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALYREF	ENSSPAP00000029132	ENSSPAP00000014818	ENSSPAP00000029132	Aly/REF export factor.	RRM domain-containing protein.	0.879
ALYREF	LOC103363951	ENSSPAP00000014818	ENSSPAP00000008496	Aly/REF export factor.	RRM domain-containing protein.	0.884
ALYREF	LOC103366532	ENSSPAP00000014818	ENSSPAP00000022550	Aly/REF export factor.	RRM domain-containing protein.	0.900
ALYREF	NCBP1	ENSSPAP00000014818	ENSSPAP00000016693	Aly/REF export factor.	Nuclear cap binding protein subunit 1.	0.981
ALYREF	cdc5l	ENSSPAP00000014818	ENSSPAP00000030891	Aly/REF export factor.	CDC5 cell division cycle 5-like (S. pombe).	0.556
ALYREF	ncbp2	ENSSPAP00000014818	ENSSPAP00000028694	Aly/REF export factor.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.982
ALYREF	nxf1	ENSSPAP00000014818	ENSSPAP00000009625	Aly/REF export factor.	Zgc:153681.	0.998
ALYREF	srsf2	ENSSPAP00000014818	ENSSPAP00000012812	Aly/REF export factor.	RRM domain-containing protein.	0.877
ENSSPAP00000029132	ALYREF	ENSSPAP00000029132	ENSSPAP00000014818	RRM domain-containing protein.	Aly/REF export factor.	0.879
ENSSPAP00000029132	LOC103363951	ENSSPAP00000029132	ENSSPAP00000008496	RRM domain-containing protein.	RRM domain-containing protein.	0.900
ENSSPAP00000029132	LOC103366532	ENSSPAP00000029132	ENSSPAP00000022550	RRM domain-containing protein.	RRM domain-containing protein.	0.882
ENSSPAP00000029132	LOC103370233	ENSSPAP00000029132	ENSSPAP00000015986	RRM domain-containing protein.	SRSF protein kinase 1b.	0.926
ENSSPAP00000029132	NCBP1	ENSSPAP00000029132	ENSSPAP00000016693	RRM domain-containing protein.	Nuclear cap binding protein subunit 1.	0.882
ENSSPAP00000029132	cdc5l	ENSSPAP00000029132	ENSSPAP00000030891	RRM domain-containing protein.	CDC5 cell division cycle 5-like (S. pombe).	0.876
ENSSPAP00000029132	ncbp2	ENSSPAP00000029132	ENSSPAP00000028694	RRM domain-containing protein.	Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...]	0.941
ENSSPAP00000029132	nxf1	ENSSPAP00000029132	ENSSPAP00000009625	RRM domain-containing protein.	Zgc:153681.	0.948
ENSSPAP00000029132	srpk1	ENSSPAP00000029132	ENSSPAP00000008538	RRM domain-containing protein.	SRSF protein kinase 1a.	0.926
ENSSPAP00000029132	srsf2	ENSSPAP00000029132	ENSSPAP00000012812	RRM domain-containing protein.	RRM domain-containing protein.	0.897
LOC103363951	ALYREF	ENSSPAP00000008496	ENSSPAP00000014818	RRM domain-containing protein.	Aly/REF export factor.	0.884
LOC103363951	ENSSPAP00000029132	ENSSPAP00000008496	ENSSPAP00000029132	RRM domain-containing protein.	RRM domain-containing protein.	0.900

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.895

expected number of edges:

11

PPI enrichment p-value:

1.9e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 100

1.34

2.22

1.96e-10

GO:0009059

Macromolecule biosynthetic process

11 of 164

1.17

1.72

1.96e-10

GO:0010467

Gene expression

11 of 187

1.11

1.57

1.96e-10

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 244

1.0

1.26

1.51e-09

GO:0044238

Primary metabolic process

11 of 736

0.52

0.45

0.00011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 55

1.6

3.41

7.00e-13

GO:0019843

rRNA binding

8 of 41

1.64

3.03

5.68e-10

GO:0003723

RNA binding

9 of 99

1.3

1.97

4.42e-09

GO:0070180

Large ribosomal subunit rRNA binding

2 of 2

2.34

1.08

0.0103

GO:0000049

tRNA binding

3 of 24

1.44

0.83

0.0156

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 57

1.59

3.45

1.16e-13

GO:0044391

Ribosomal subunit

4 of 14

1.8

2.22

9.87e-06

GO:0015934

Large ribosomal subunit

3 of 8

1.92

1.89

0.00012

GO:0032991

Protein-containing complex

5 of 143

0.89

0.69

0.0026

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:27330141

(2016) Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity.

7 of 26

1.78

2.96

3.35e-08

PMID:28977619

(2017) The stability of an mRNA is influenced by its concentration: a potential physical mechanism to regulate gene expression.

8 of 51

1.54

2.45

3.35e-08

PMID:22043294

(2011) Gut microbiome metagenomics analysis suggests a functional model for the development of autoimmunity for type 1 diabetes.

4 of 8

2.04

1.98

0.00011

PMID:20019804

(2009) Transcriptome and proteome exploration to model translation efficiency and protein stability in Lactococcus lactis.

6 of 65

1.31

1.32

0.00015

PMID:30779773

(2019) Multiplexing polysome profiling experiments to study translation in Escherichia coli.

3 of 7

1.98

1.24

0.0040

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:95

rRNA-binding

8 of 31

1.76

3.73

1.37e-11

CL:86

Ribosome, and Translational elongation

11 of 69

1.55

3.38

1.30e-14

CL:89

Ribosome

10 of 59

1.57

3.36

2.01e-13

CL:91

Ribosome

9 of 50

1.6

3.28

4.05e-12

CL:147

Large ribosomal subunit rRNA binding, and Translation regulation

4 of 5

2.25

3.03

9.25e-07

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

llm03010

Ribosome

10 of 55

1.6

3.53

9.24e-14

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0015934

Large ribosomal subunit

5 of 10

2.04

3.23

1.01e-07

GOCC:0005840

Ribosome

8 of 45

1.59

2.87

9.60e-10

GOCC:0022625

Cytosolic large ribosomal subunit

3 of 6

2.04

1.94

0.00013

GOCC:0043229

Intracellular organelle

10 of 224

0.99

1.19

5.88e-08

GOCC:0032991

Protein-containing complex

6 of 331

0.6

0.38

0.0297

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 56

1.6

3.45

2.01e-13

KW-0699

rRNA-binding

8 of 39

1.66

3.24

9.68e-11

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