STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
herc4HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1046 aa)    
Predicted Functional Partners:
ENSSPAP00000023371
HECT domain-containing protein.
  
 
0.882
tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.842
herc3
HECT and RLD domain containing E3 ubiquitin protein ligase 3.
  
  
 
0.833
ENSSPAP00000016068
Uncharacterized protein.
  
  
 
0.822
LOC103355560
Membrane associated guanylate kinase, WW and PDZ domain containing 3b.
    
  0.815
ENSSPAP00000009435
PDZ domain-containing protein.
    
  0.815
magi3
Uncharacterized protein.
    
  0.815
tsc2
TSC complex subunit 2.
    
 0.759
LOC103371291
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.749
trip12
Thyroid hormone receptor interactor 12.
   
 
0.746
Your Current Organism:
Stegastes partitus
NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.