ENSSPAP00000029945 protein (Stegastes partitus)

Nodes:

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white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

ENSSPAP00000029945

Uncharacterized protein. (167 aa)

Predicted Functional Partners:

fau

0.913

LOC103372083

0.840

pla2g4a

0.826

rag2

0.825

rpl21

0.803

bard1

0.780

babam1

0.770

mrpl2

0.736

rpl8

0.720

ENSSPAP00000029682

0.719

Your Current Organism:

Stegastes partitus

NCBI taxonomy Id: 144197
Other names: S. partitus, bicolor damselfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSSPAP00000029682	ENSSPAP00000029945	ENSSPAP00000029682	ENSSPAP00000029945	Uncharacterized protein.	Uncharacterized protein.	0.719
ENSSPAP00000029682	LOC103372083	ENSSPAP00000029682	ENSSPAP00000022588	Uncharacterized protein.	Heme-binding protein soul4.	0.567
ENSSPAP00000029682	fau	ENSSPAP00000029682	ENSSPAP00000000178	Uncharacterized protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.999
ENSSPAP00000029682	mrpl2	ENSSPAP00000029682	ENSSPAP00000008655	Uncharacterized protein.	Mitochondrial ribosomal protein L2.	0.994
ENSSPAP00000029682	rpl21	ENSSPAP00000029682	ENSSPAP00000019939	Uncharacterized protein.	Ribosomal protein L21.	0.999
ENSSPAP00000029682	rpl8	ENSSPAP00000029682	ENSSPAP00000011312	Uncharacterized protein.	Ribosomal protein L8.	0.999
ENSSPAP00000029945	ENSSPAP00000029682	ENSSPAP00000029945	ENSSPAP00000029682	Uncharacterized protein.	Uncharacterized protein.	0.719
ENSSPAP00000029945	LOC103372083	ENSSPAP00000029945	ENSSPAP00000022588	Uncharacterized protein.	Heme-binding protein soul4.	0.840
ENSSPAP00000029945	babam1	ENSSPAP00000029945	ENSSPAP00000005023	Uncharacterized protein.	BRISC and BRCA1 A complex member 1.	0.770
ENSSPAP00000029945	bard1	ENSSPAP00000029945	ENSSPAP00000005852	Uncharacterized protein.	BRCA1 associated RING domain 1.	0.780
ENSSPAP00000029945	fau	ENSSPAP00000029945	ENSSPAP00000000178	Uncharacterized protein.	40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family.	0.913
ENSSPAP00000029945	mrpl2	ENSSPAP00000029945	ENSSPAP00000008655	Uncharacterized protein.	Mitochondrial ribosomal protein L2.	0.736
ENSSPAP00000029945	pla2g4a	ENSSPAP00000029945	ENSSPAP00000020508	Uncharacterized protein.	Phospholipase A2.	0.826
ENSSPAP00000029945	rag2	ENSSPAP00000029945	ENSSPAP00000019494	Uncharacterized protein.	Recombination activating gene 2.	0.825
ENSSPAP00000029945	rpl21	ENSSPAP00000029945	ENSSPAP00000019939	Uncharacterized protein.	Ribosomal protein L21.	0.803
ENSSPAP00000029945	rpl8	ENSSPAP00000029945	ENSSPAP00000011312	Uncharacterized protein.	Ribosomal protein L8.	0.720
LOC103372083	ENSSPAP00000029682	ENSSPAP00000022588	ENSSPAP00000029682	Heme-binding protein soul4.	Uncharacterized protein.	0.567
LOC103372083	ENSSPAP00000029945	ENSSPAP00000022588	ENSSPAP00000029945	Heme-binding protein soul4.	Uncharacterized protein.	0.840
LOC103372083	bard1	ENSSPAP00000022588	ENSSPAP00000005852	Heme-binding protein soul4.	BRCA1 associated RING domain 1.	0.588
LOC103372083	mrpl2	ENSSPAP00000022588	ENSSPAP00000008655	Heme-binding protein soul4.	Mitochondrial ribosomal protein L2.	0.640

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.859

expected number of edges:

10

PPI enrichment p-value:

0.105

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032957

Inositol trisphosphate metabolic process

4 of 5

3.24

4.19

2.40e-08

GO:0070266

Necroptotic process

4 of 13

2.83

3.59

2.27e-07

GO:0006066

Alcohol metabolic process

5 of 291

1.58

1.61

0.00014

GO:0052746

Inositol phosphorylation

2 of 3

3.16

1.54

0.0017

GO:0032958

Inositol phosphate biosynthetic process

2 of 14

2.5

0.97

0.0167

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000825

Inositol tetrakisphosphate 6-kinase activity

4 of 4

3.34

4.61

4.39e-09

GO:0051766

Inositol trisphosphate kinase activity

4 of 9

2.99

4.26

1.49e-08

GO:0003993

Acid phosphatase activity

3 of 7

2.97

2.88

5.66e-06

GO:0102732

myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

GO:0052726

inositol-1,3,4-trisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30075

Acid phosphatase activity, and Alkaline phosphatase activity

6 of 14

2.97

6.68

3.23e-13

CL:30076

Acid phosphatase activity, and Phosphodiesterase I activity

4 of 7

3.1

4.32

1.27e-08

CL:38050

Inositol trisphosphate kinase activity, and Inositol tetrakisphosphate phosphatase activity

4 of 17

2.71

3.62

1.72e-07

CL:38074

Inositol phosphorylation, and Inositol tetrakisphosphate 5-kinase activity

3 of 5

3.12

2.98

3.89e-06

CL:30089

Alkaline phosphatase activity, and Acid phosphatase activity

2 of 7

2.8

1.41

0.0028

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00730

Thiamine metabolism

4 of 21

2.62

3.84

5.24e-08

map00740

Riboflavin metabolism

3 of 19

2.54

2.8

5.30e-06

map00562

Inositol phosphate metabolism

5 of 169

1.81

2.66

5.39e-07

map04070

Phosphatidylinositol signaling system

4 of 181

1.68

1.89

4.16e-05

map01100

Metabolic pathways

11 of 3242

0.87

0.96

5.24e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483249

Inositol phosphate metabolism

5 of 70

2.19

3.28

1.94e-07

MAP-196819

Vitamin B1 (thiamin) metabolism

2 of 5

2.94

1.47

0.0022

MAP-1855191

Synthesis of IPs in the nucleus

2 of 7

2.8

1.41

0.0028

MAP-1855167

Synthesis of pyrophosphates in the cytosol

2 of 10

2.64

1.3

0.0042

MAP-196849

Metabolism of water-soluble vitamins and cofactors

3 of 192

1.53

0.79

0.0228

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00149

Calcineurin-like phosphoesterase

3 of 14

2.67

2.15

0.00011

PF05770

Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain

2 of 2

3.34

1.6

0.0013

PF03770

Inositol polyphosphate kinase

2 of 9

2.69

1.15

0.0081

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