A0A2T2NW12 protein (Corynespora cassiicola) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

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Cooccurrence

Coexpression

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[Homology]

Score

A0A2T2NW12

NOT2_3_5 domain-containing protein. (689 aa)

Predicted Functional Partners:

A0A2T2P2J3

0.985

A0A2T2P0F5

0.984

A0A2T2P3J0

0.984

A0A2T2P5L3

0.984

A0A2T2NCC4

0.968

A0A2T2P7Q4

0.952

A0A2T2P7P3

0.928

A0A2T2NJX1

0.927

A0A2T2PCH7

0.883

A0A2T2NAS2

0.858

Your Current Organism:

Corynespora cassiicola

NCBI taxonomy Id: 1448308
Other names: C. cassiicola Philippines, Corynespora cassiicola INRA-Clermont Ferrand, Corynespora cassiicola Philippines

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2T2NAS2	A0A2T2NCC4	PAT1 domain-containing protein.	Endo/exonuclease/phosphatase domain-containing protein.	0.951
A0A2T2NAS2	A0A2T2NJX1	PAT1 domain-containing protein.	Uncharacterized protein.	0.888
A0A2T2NAS2	A0A2T2NW12	PAT1 domain-containing protein.	NOT2_3_5 domain-containing protein.	0.858
A0A2T2NAS2	A0A2T2P0F5	PAT1 domain-containing protein.	Ribonuclease H-like protein.	0.988
A0A2T2NAS2	A0A2T2P2J3	PAT1 domain-containing protein.	Not1-domain-containing protein.	0.950
A0A2T2NAS2	A0A2T2P3J0	PAT1 domain-containing protein.	CCR4-NOT transcription complex.	0.968
A0A2T2NAS2	A0A2T2P5L3	PAT1 domain-containing protein.	Rcd1-domain-containing protein.	0.431
A0A2T2NAS2	A0A2T2P7P3	PAT1 domain-containing protein.	Uncharacterized protein.	0.890
A0A2T2NAS2	A0A2T2P7Q4	PAT1 domain-containing protein.	Uncharacterized protein.	0.890
A0A2T2NCC4	A0A2T2NAS2	Endo/exonuclease/phosphatase domain-containing protein.	PAT1 domain-containing protein.	0.951
A0A2T2NCC4	A0A2T2NW12	Endo/exonuclease/phosphatase domain-containing protein.	NOT2_3_5 domain-containing protein.	0.968
A0A2T2NCC4	A0A2T2P0F5	Endo/exonuclease/phosphatase domain-containing protein.	Ribonuclease H-like protein.	0.996
A0A2T2NCC4	A0A2T2P2J3	Endo/exonuclease/phosphatase domain-containing protein.	Not1-domain-containing protein.	0.996
A0A2T2NCC4	A0A2T2P3J0	Endo/exonuclease/phosphatase domain-containing protein.	CCR4-NOT transcription complex.	0.991
A0A2T2NCC4	A0A2T2P5L3	Endo/exonuclease/phosphatase domain-containing protein.	Rcd1-domain-containing protein.	0.992
A0A2T2NCC4	A0A2T2P7P3	Endo/exonuclease/phosphatase domain-containing protein.	Uncharacterized protein.	0.968
A0A2T2NCC4	A0A2T2P7Q4	Endo/exonuclease/phosphatase domain-containing protein.	Uncharacterized protein.	0.968
A0A2T2NJX1	A0A2T2NAS2	Uncharacterized protein.	PAT1 domain-containing protein.	0.888
A0A2T2NJX1	A0A2T2NW12	Uncharacterized protein.	NOT2_3_5 domain-containing protein.	0.927
A0A2T2NJX1	A0A2T2P0F5	Uncharacterized protein.	Ribonuclease H-like protein.	0.976

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.855

expected number of edges:

13

PPI enrichment p-value:

2.76e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:2000272

Negative regulation of signaling receptor activity

3 of 4

3.06

2.55

2.32e-05

GO:0050730

Regulation of peptidyl-tyrosine phosphorylation

3 of 5

2.96

2.54

2.32e-05

GO:0007166

Cell surface receptor signaling pathway

5 of 147

1.72

1.98

2.64e-05

GO:0006469

Negative regulation of protein kinase activity

3 of 19

2.38

1.97

0.00020

GO:0048585

Negative regulation of response to stimulus

4 of 87

1.85

1.76

0.00020

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016755

Aminoacyltransferase activity

3 of 7

2.82

2.42

3.67e-05

GO:0017124

SH3 domain binding

3 of 9

2.71

2.41

3.67e-05

GO:0001784

Phosphotyrosine residue binding

3 of 11

2.62

2.39

3.67e-05

GO:0005102

Signaling receptor binding

4 of 59

2.02

2.17

3.67e-05

GO:0019901

Protein kinase binding

3 of 76

1.78

1.25

0.0029

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045121

Membrane raft

3 of 11

2.62

2.29

5.72e-05

GO:0071944

Cell periphery

5 of 929

0.92

0.49

0.0458

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:662

Mixed, incl. Regulation of cell migration, and Protein tyrosine kinase activity

6 of 61

2.18

4.03

2.71e-09

CL:685

Phosphotyrosine residue binding, and Transmembrane receptor protein kinase activity

3 of 20

2.36

2.07

0.00012

CL:768

VHS domain, and Semaphorin interactions

2 of 5

2.79

1.61

0.0012

CL:688

Mixed, incl. Phosphotyrosine residue binding, and Basal plasma membrane

2 of 13

2.37

1.22

0.0055

CL:1687

Mixed, incl. Protein tyrosine phosphatase, catalytic domain, and EGF-like domain

2 of 28

2.04

0.89

0.0212

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04144

Endocytosis

4 of 223

1.44

1.2

0.0013

map04120

Ubiquitin mediated proteolysis

3 of 173

1.42

0.87

0.0114

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045121

Membrane raft

3 of 8

2.76

2.47

2.94e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02761

CBL proto-oncogene N-terminus, EF hand-like domain

3 of 14

2.52

2.0

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR024159

Adaptor protein Cbl, PTB domain

3 of 7

2.82

2.21

8.99e-05

IPR014741

Adaptor protein Cbl, EF hand-like

3 of 15

2.49

1.89

0.00030

IPR000980

SH2 domain

3 of 84

1.74

0.81

0.0257

IPR036860

SH2 domain superfamily

3 of 94

1.69

0.79

0.0268

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00252

Src homology 2 domains

3 of 93

1.69

0.96

0.0114

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