KALB_1168 protein (Kutzneria albida) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

KALB_1168

Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism. (231 aa)

Predicted Functional Partners:

KALB_1169

0.996

KALB_1858

0.841

KALB_5383

0.838

KALB_5643

0.830

KALB_5728

0.830

KALB_598

0.822

KALB_6824

0.822

KALB_1167

0.815

KALB_6621

0.807

KALB_4616

0.778

Your Current Organism:

Kutzneria albida

NCBI taxonomy Id: 1449976
Other names: K. albida DSM 43870, Kutzneria albida DSM 43870

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
KALB_1167	KALB_1168	Peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin.	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	0.815
KALB_1167	KALB_1169	Peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin.	Signal transduction histidine kinase-like protein.	0.889
KALB_1168	KALB_1167	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	Peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin.	0.815
KALB_1168	KALB_1169	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	Signal transduction histidine kinase-like protein.	0.996
KALB_1168	KALB_1858	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	Integral membrane sensor signal transduction histidine kinase.	0.841
KALB_1168	KALB_4616	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	Hypothetical protein.	0.778
KALB_1168	KALB_5383	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	Hypothetical protein.	0.838
KALB_1168	KALB_5643	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	Hypothetical protein.	0.830
KALB_1168	KALB_5728	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	Hypothetical protein.	0.830
KALB_1168	KALB_598	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	Integral membrane sensor signal transduction histidine kinase.	0.822
KALB_1168	KALB_6621	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	Hypothetical protein.	0.807
KALB_1168	KALB_6824	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	Hypothetical protein.	0.822
KALB_1169	KALB_1167	Signal transduction histidine kinase-like protein.	Peptidase M15B and M15C DD-carboxypeptidase VanY/endolysin.	0.889
KALB_1169	KALB_1168	Signal transduction histidine kinase-like protein.	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	0.996
KALB_1169	KALB_4616	Signal transduction histidine kinase-like protein.	Hypothetical protein.	0.620
KALB_1858	KALB_1168	Integral membrane sensor signal transduction histidine kinase.	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	0.841
KALB_1858	KALB_4616	Integral membrane sensor signal transduction histidine kinase.	Hypothetical protein.	0.631
KALB_1858	KALB_6621	Integral membrane sensor signal transduction histidine kinase.	Hypothetical protein.	0.413
KALB_4616	KALB_1168	Hypothetical protein.	Member of the two-component regulatory system CutS/CutR, involved in the regulation of copper metabolism. CutR suppresses a defective melC1 gene, encoding a putative copper-transfer gene, probably by altering copper metabolism.	0.778
KALB_4616	KALB_1169	Hypothetical protein.	Signal transduction histidine kinase-like protein.	0.620

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Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.876

expected number of edges:

10

PPI enrichment p-value:

0.00102

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006284

Base-excision repair

7 of 20

2.44

5.78

1.47e-12

GO:0006285

Base-excision repair, AP site formation

5 of 8

2.69

4.53

2.62e-09

GO:0006281

DNA repair

8 of 234

1.43

2.13

6.25e-08

GO:0097510

Base-excision repair, AP site formation via deaminated base removal

2 of 2

2.89

1.41

0.0028

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019104

DNA N-glycosylase activity

5 of 12

2.51

4.26

5.27e-09

GO:0003906

DNA-(apurinic or apyrimidinic site) endonuclease activity

4 of 5

2.79

3.91

5.28e-08

GO:0140097

Catalytic activity, acting on DNA

9 of 153

1.66

3.39

1.87e-11

GO:0000702

Oxidized base lesion DNA N-glycosylase activity

3 of 8

2.47

2.28

5.29e-05

GO:0140078

Class I DNA-(apurinic or apyrimidinic site) endonuclease activity

2 of 3

2.72

1.47

0.0021

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7191

Base-excision repair

5 of 10

2.59

4.32

5.37e-09

CL:7196

DNA-(apurinic or apyrimidinic site) endonuclease activity, and DNA dealkylation

4 of 5

2.79

3.7

1.38e-07

CL:6867

DNA metabolic process

7 of 175

1.49

2.17

2.66e-07

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03410

Base excision repair

7 of 40

2.13

4.97

4.54e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-73929

Base-Excision Repair, AP Site Formation

4 of 14

2.35

2.89

2.47e-06

MAP-73884

Base Excision Repair

5 of 46

1.93

2.57

2.47e-06

MAP-73928

Depyrimidination

3 of 7

2.52

2.34

4.24e-05

MAP-110329

Cleavage of the damaged pyrimidine

3 of 7

2.52

2.34

4.24e-05

MAP-73894

DNA Repair

6 of 223

1.32

1.45

4.22e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0227

DNA damage

3 of 27

1.94

1.44

0.0014

KW-0234

DNA repair

2 of 21

1.87

0.78

0.0330

KW-0378

Hydrolase

4 of 271

1.06

0.58

0.0330

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000445

Helix-hairpin-helix motif

2 of 2

2.89

0.91

0.0224

IPR023170

Helix-hairpin-helix, base-excision DNA repair, C-terminal

2 of 4

2.59

0.86

0.0280

IPR003265

HhH-GPD domain

2 of 4

2.59

0.86

0.0280

IPR011257

DNA glycosylase

2 of 7

2.35

0.81

0.0335

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00478

Endonuclease III

2 of 3

2.72

1.29

0.0045

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