KALB_3412 protein (Kutzneria albida) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

KALB_3412

Hypothetical protein; Belongs to the cytochrome P450 family. (405 aa)

Predicted Functional Partners:

KALB_6133

0.963

KALB_2591

0.893

KALB_5512

0.891

acuAVIII

0.886

KALB_6154

0.885

KALB_3882

0.868

KALB_3411

0.838

KALB_3410

0.807

KALB_3409

0.773

acuAV

0.757

Your Current Organism:

Kutzneria albida

NCBI taxonomy Id: 1449976
Other names: K. albida DSM 43870, Kutzneria albida DSM 43870

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KALB_2591	KALB_3411	KALB_2591	KALB_3411	Hypothetical protein.	Cytochrome P450.	0.893
KALB_2591	KALB_3412	KALB_2591	KALB_3412	Hypothetical protein.	Hypothetical protein; Belongs to the cytochrome P450 family.	0.893
KALB_2591	KALB_3882	KALB_2591	KALB_3882	Hypothetical protein.	Amino acid adenylation domain-containing protein.	0.846
KALB_2591	KALB_5512	KALB_2591	KALB_5512	Hypothetical protein.	Hypothetical protein.	0.888
KALB_2591	KALB_6133	KALB_2591	KALB_6133	Hypothetical protein.	Hypothetical protein.	0.997
KALB_2591	KALB_6154	KALB_2591	KALB_6154	Hypothetical protein.	Hypothetical protein.	0.991
KALB_2591	acuAV	KALB_2591	KALB_6563	Hypothetical protein.	PKS I.	0.995
KALB_2591	acuAVIII	KALB_2591	KALB_6560	Hypothetical protein.	PKS I.	0.996
KALB_3409	KALB_3410	KALB_3409	KALB_3410	VioB - polyketide synthase.	FAD-binding monooxygenase.	0.945
KALB_3409	KALB_3411	KALB_3409	KALB_3411	VioB - polyketide synthase.	Cytochrome P450.	0.820
KALB_3409	KALB_3412	KALB_3409	KALB_3412	VioB - polyketide synthase.	Hypothetical protein; Belongs to the cytochrome P450 family.	0.773
KALB_3409	KALB_6133	KALB_3409	KALB_6133	VioB - polyketide synthase.	Hypothetical protein.	0.782
KALB_3409	KALB_6154	KALB_3409	KALB_6154	VioB - polyketide synthase.	Hypothetical protein.	0.403
KALB_3409	acuAV	KALB_3409	KALB_6563	VioB - polyketide synthase.	PKS I.	0.440
KALB_3409	acuAVIII	KALB_3409	KALB_6560	VioB - polyketide synthase.	PKS I.	0.403
KALB_3410	KALB_3409	KALB_3410	KALB_3409	FAD-binding monooxygenase.	VioB - polyketide synthase.	0.945
KALB_3410	KALB_3411	KALB_3410	KALB_3411	FAD-binding monooxygenase.	Cytochrome P450.	0.829
KALB_3410	KALB_3412	KALB_3410	KALB_3412	FAD-binding monooxygenase.	Hypothetical protein; Belongs to the cytochrome P450 family.	0.807
KALB_3411	KALB_2591	KALB_3411	KALB_2591	Cytochrome P450.	Hypothetical protein.	0.893
KALB_3411	KALB_3409	KALB_3411	KALB_3409	Cytochrome P450.	VioB - polyketide synthase.	0.820

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.962

expected number of edges:

12

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006351

Transcription, DNA-templated

11 of 156

2.14

7.45

2.46e-20

GO:0006360

Transcription by RNA polymerase I

6 of 11

3.03

7.26

2.80e-14

GO:0006352

DNA-templated transcription, initiation

7 of 49

2.44

6.29

9.77e-14

GO:0006361

Transcription initiation from RNA polymerase I promoter

4 of 6

3.11

4.78

1.80e-09

GO:0001188

RNA polymerase I preinitiation complex assembly

3 of 5

3.07

3.24

1.23e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140223

General transcription initiation factor activity

3 of 15

2.59

2.05

0.00016

GO:0001181

RNA polymerase I general transcription initiation factor activity

2 of 2

3.29

1.68

0.00095

GO:0001179

RNA polymerase I general transcription initiation factor binding

2 of 2

3.29

1.68

0.00095

GO:0003899

DNA-directed 5-3 RNA polymerase activity

2 of 16

2.39

1.08

0.0103

GO:0008134

Transcription factor binding

3 of 105

1.74

1.05

0.0076

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0055029

Nuclear DNA-directed RNA polymerase complex

8 of 66

2.37

6.79

2.27e-15

GO:0005675

Transcription factor TFIIH holo complex

4 of 7

3.05

4.74

1.92e-09

GO:0005736

RNA polymerase I complex

4 of 9

2.94

4.58

3.38e-09

GO:0000439

Transcription factor TFIIH core complex

3 of 6

2.99

3.48

4.24e-07

GO:0005730

Nucleolus

5 of 300

1.51

1.84

1.12e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1775

RNA Polymerase II Pre-transcription Events, and RNA Polymerase III Transcription Initiation

11 of 112

2.28

8.72

4.38e-22

CL:1939

RNA Polymerase III Transcription Initiation From Type 1 Promoter, and RNA polymerase I complex

6 of 25

2.67

6.09

1.55e-12

CL:1793

Transcription factor TFIIH holo complex, and RNA polymerase II general transcription initiation factor activity

5 of 14

2.84

5.43

6.24e-11

CL:1977

RNA polymerase I complex

4 of 5

3.19

4.8

1.76e-09

CL:1796

Transcription factor TFIIH holo complex

3 of 5

3.07

3.23

1.32e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pcan03020

RNA polymerase

2 of 18

2.33

1.21

0.0057

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-73772

RNA Polymerase I Promoter Escape

11 of 25

2.93

14.18

7.24e-29

MAP-73864

RNA Polymerase I Transcription

11 of 33

2.81

13.4

4.62e-28

MAP-73854

RNA Polymerase I Promoter Clearance

11 of 33

2.81

13.4

4.62e-28

MAP-73762

RNA Polymerase I Transcription Initiation

10 of 25

2.89

12.59

1.18e-25

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

5 of 35

2.44

4.43

1.74e-09

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

8 of 63

2.39

6.88

1.80e-15

GOCC:0032806

Carboxy-terminal domain protein kinase complex

4 of 12

2.81

4.19

1.54e-08

GOCC:0016591

RNA polymerase II, holoenzyme

4 of 35

2.35

3.22

4.94e-07

GOCC:0031981

Nuclear lumen

5 of 561

1.24

1.13

0.00053

GOCC:0005634

Nucleus

7 of 1786

0.88

0.75

0.00061

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

2 of 10

2.59

1.3

0.0042

KW-0548

Nucleotidyltransferase

2 of 17

2.36

1.23

0.0054

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF06870

A49-like RNA polymerase I associated factor

2 of 2

3.29

1.49

0.0021

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009668

RNA polymerase I associated factor, A49-like

2 of 2

3.29

1.24

0.0059

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