AMK14312.1 protein (methanogenic archaeon mixed)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AMK14312.1

DNA-directed RNA polymerase subunit P RpoP. (46 aa)

Predicted Functional Partners:

AMK13173.1

0.999

AMK13194.1

0.999

AMK13296.1

0.999

AMK14038.1

0.999

AMK14109.1

0.999

AMK14242.1

0.999

AMK14464.1

0.999

AMK14465.1

0.999

AMK14545.1

0.999

AMK13087.1

0.997

Your Current Organism:

methanogenic archaeon mixed

NCBI taxonomy Id: 1452364
Other names: m. archaeon mixed culture ISO4-G1, methanogenic archaeon mixed culture ISO4-G1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMK13087.1	AMK13173.1	AUP07_0027	AUP07_0113	Transcription initiation factor IIB.	DNA-directed RNA polymerase subunit K RpoK.	0.996
AMK13087.1	AMK13194.1	AUP07_0027	AUP07_0134	Transcription initiation factor IIB.	Transcription termination factor Tfs.	0.992
AMK13087.1	AMK13296.1	AUP07_0027	AUP07_0238	Transcription initiation factor IIB.	DNA-directed RNA polymerase subunit N RpoN.	0.992
AMK13087.1	AMK14242.1	AUP07_0027	AUP07_1201	Transcription initiation factor IIB.	DNA-directed RNA polymerase subunit D RpoD.	0.995
AMK13087.1	AMK14312.1	AUP07_0027	AUP07_1275	Transcription initiation factor IIB.	DNA-directed RNA polymerase subunit P RpoP.	0.997
AMK13087.1	AMK14464.1	AUP07_0027	AUP07_1427	Transcription initiation factor IIB.	DNA-directed RNA polymerase subunit B RpoB.	0.995
AMK13087.1	AMK14465.1	AUP07_0027	AUP07_1428	Transcription initiation factor IIB.	DNA-directed RNA polymerase subunit H RpoH.	0.999
AMK13087.1	AMK14545.1	AUP07_0027	AUP07_1512	Transcription initiation factor IIB.	Helicase.	0.997
AMK13173.1	AMK13087.1	AUP07_0113	AUP07_0027	DNA-directed RNA polymerase subunit K RpoK.	Transcription initiation factor IIB.	0.996
AMK13173.1	AMK13194.1	AUP07_0113	AUP07_0134	DNA-directed RNA polymerase subunit K RpoK.	Transcription termination factor Tfs.	0.999
AMK13173.1	AMK13296.1	AUP07_0113	AUP07_0238	DNA-directed RNA polymerase subunit K RpoK.	DNA-directed RNA polymerase subunit N RpoN.	0.999
AMK13173.1	AMK14038.1	AUP07_0113	AUP07_0995	DNA-directed RNA polymerase subunit K RpoK.	DNA-directed RNA polymerase subunit E RpoE1.	0.999
AMK13173.1	AMK14109.1	AUP07_0113	AUP07_1067	DNA-directed RNA polymerase subunit K RpoK.	DNA-directed RNA polymerase subunit L RpoL.	0.999
AMK13173.1	AMK14242.1	AUP07_0113	AUP07_1201	DNA-directed RNA polymerase subunit K RpoK.	DNA-directed RNA polymerase subunit D RpoD.	0.999
AMK13173.1	AMK14312.1	AUP07_0113	AUP07_1275	DNA-directed RNA polymerase subunit K RpoK.	DNA-directed RNA polymerase subunit P RpoP.	0.999
AMK13173.1	AMK14464.1	AUP07_0113	AUP07_1427	DNA-directed RNA polymerase subunit K RpoK.	DNA-directed RNA polymerase subunit B RpoB.	0.999
AMK13173.1	AMK14465.1	AUP07_0113	AUP07_1428	DNA-directed RNA polymerase subunit K RpoK.	DNA-directed RNA polymerase subunit H RpoH.	0.999
AMK13173.1	AMK14545.1	AUP07_0113	AUP07_1512	DNA-directed RNA polymerase subunit K RpoK.	Helicase.	0.997
AMK13194.1	AMK13087.1	AUP07_0134	AUP07_0027	Transcription termination factor Tfs.	Transcription initiation factor IIB.	0.992
AMK13194.1	AMK13173.1	AUP07_0134	AUP07_0113	Transcription termination factor Tfs.	DNA-directed RNA polymerase subunit K RpoK.	0.999

page 1 of 6

Network Stats

number of nodes:

4

number of edges:

4

average node degree:

2

avg. local clustering coefficient:

0.833

expected number of edges:

3

PPI enrichment p-value:

0.331

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006096

Glycolytic process

8 of 18

2.19

5.5

3.20e-13

GO:0006006

Glucose metabolic process

4 of 13

2.03

2.6

3.64e-06

GO:0006091

Generation of precursor metabolites and energy

9 of 142

1.34

2.15

7.09e-10

GO:0005975

Carbohydrate metabolic process

10 of 176

1.29

2.11

5.19e-11

GO:0006094

Gluconeogenesis

3 of 8

2.11

2.04

9.25e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009986

Cell surface

2 of 3

2.36

1.31

0.0038

GO:0005737

Cytoplasm

11 of 1372

0.44

0.36

0.0021

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2472

Glycolysis, and Pentose-phosphate shunt

9 of 16

2.29

6.92

2.11e-16

CL:2473

Glycolysis, and Glyceraldehyde-3-phosphate dehydrogenase, type I

7 of 10

2.38

5.92

4.02e-13

CL:2476

Glycolysis

5 of 5

2.54

4.56

1.37e-09

CL:2492

Pentose-phosphate shunt, and Shikimate kinase

2 of 6

2.06

0.96

0.0152

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

8 of 41

1.83

4.08

4.41e-12

map01200

Carbon metabolism

11 of 133

1.46

2.97

2.06e-14

map00680

Methane metabolism

5 of 31

1.75

2.55

5.55e-07

map01230

Biosynthesis of amino acids

9 of 143

1.34

2.16

4.64e-10

map00030

Pentose phosphate pathway

4 of 24

1.76

2.12

1.41e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009986

Cell surface

2 of 11

1.8

0.72

0.0421

GOCC:0005829

Cytosol

7 of 537

0.65

0.4

0.0333

GOCC:0005737

Cytoplasm

10 of 1084

0.5

0.37

0.0088

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

7 of 9

2.43

6.02

3.70e-13

KW-0312

Gluconeogenesis

3 of 5

2.32

2.08

0.00011

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00855

Phosphoglycerate mutase family

2 of 5

2.14

0.93

0.0188

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