AMK14450.1 protein (methanogenic archaeon mixed)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

AMK14450.1

EamA-like transporter family protein. (308 aa)

Predicted Functional Partners:

AMK14449.1

0.691

AMK13211.1

0.667

AMK14482.1

0.553

AMK14448.1

0.540

AMK13813.1

0.493

AMK13814.1

0.493

AMK13297.1

0.468

AMK13303.1

0.468

AMK14291.1

0.468

AMK14447.1

0.453

Your Current Organism:

methanogenic archaeon mixed

NCBI taxonomy Id: 1452364
Other names: m. archaeon mixed culture ISO4-G1, methanogenic archaeon mixed culture ISO4-G1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMK13211.1	AMK14448.1	AUP07_0151	AUP07_1411	Undecaprenyl pyrophosphate synthetase UppS.	EamA-like transporter family protein.	0.667
AMK13211.1	AMK14449.1	AUP07_0151	AUP07_1412	Undecaprenyl pyrophosphate synthetase UppS.	EamA-like transporter family protein.	0.667
AMK13211.1	AMK14450.1	AUP07_0151	AUP07_1413	Undecaprenyl pyrophosphate synthetase UppS.	EamA-like transporter family protein.	0.667
AMK13211.1	AMK14482.1	AUP07_0151	AUP07_1446	Undecaprenyl pyrophosphate synthetase UppS.	EamA-like transporter family protein.	0.667
AMK13297.1	AMK13813.1	AUP07_0239	AUP07_0764	Transporter monovalent cation:proton antiporter-2 family.	Site-specific recombinase/resolvase.	0.493
AMK13297.1	AMK13814.1	AUP07_0239	AUP07_0765	Transporter monovalent cation:proton antiporter-2 family.	Site-specific recombinase/resolvase.	0.493
AMK13297.1	AMK14449.1	AUP07_0239	AUP07_1412	Transporter monovalent cation:proton antiporter-2 family.	EamA-like transporter family protein.	0.468
AMK13297.1	AMK14450.1	AUP07_0239	AUP07_1413	Transporter monovalent cation:proton antiporter-2 family.	EamA-like transporter family protein.	0.468
AMK13303.1	AMK13813.1	AUP07_0246	AUP07_0764	Transporter monovalent cation:proton antiporter-2 family.	Site-specific recombinase/resolvase.	0.493
AMK13303.1	AMK13814.1	AUP07_0246	AUP07_0765	Transporter monovalent cation:proton antiporter-2 family.	Site-specific recombinase/resolvase.	0.493
AMK13303.1	AMK14449.1	AUP07_0246	AUP07_1412	Transporter monovalent cation:proton antiporter-2 family.	EamA-like transporter family protein.	0.468
AMK13303.1	AMK14450.1	AUP07_0246	AUP07_1413	Transporter monovalent cation:proton antiporter-2 family.	EamA-like transporter family protein.	0.468
AMK13813.1	AMK13297.1	AUP07_0764	AUP07_0239	Site-specific recombinase/resolvase.	Transporter monovalent cation:proton antiporter-2 family.	0.493
AMK13813.1	AMK13303.1	AUP07_0764	AUP07_0246	Site-specific recombinase/resolvase.	Transporter monovalent cation:proton antiporter-2 family.	0.493
AMK13813.1	AMK13814.1	AUP07_0764	AUP07_0765	Site-specific recombinase/resolvase.	Site-specific recombinase/resolvase.	0.786
AMK13813.1	AMK14291.1	AUP07_0764	AUP07_1254	Site-specific recombinase/resolvase.	Transporter monovalent cation:proton antiporter-2 family.	0.493
AMK13813.1	AMK14449.1	AUP07_0764	AUP07_1412	Site-specific recombinase/resolvase.	EamA-like transporter family protein.	0.493
AMK13813.1	AMK14450.1	AUP07_0764	AUP07_1413	Site-specific recombinase/resolvase.	EamA-like transporter family protein.	0.493
AMK13814.1	AMK13297.1	AUP07_0765	AUP07_0239	Site-specific recombinase/resolvase.	Transporter monovalent cation:proton antiporter-2 family.	0.493
AMK13814.1	AMK13303.1	AUP07_0765	AUP07_0246	Site-specific recombinase/resolvase.	Transporter monovalent cation:proton antiporter-2 family.	0.493

page 1 of 3

Network Stats

number of nodes:

9

number of edges:

8

average node degree:

1.78

avg. local clustering coefficient:

0.889

expected number of edges:

8

PPI enrichment p-value:

0.55

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006281

DNA repair

7 of 49

1.75

3.18

7.26e-09

GO:0090304

Nucleic acid metabolic process

8 of 304

1.02

1.1

5.62e-06

GO:0006284

Base-excision repair

2 of 8

2.0

0.98

0.0174

GO:0006304

DNA modification

2 of 11

1.86

0.85

0.0286

GO:0043170

Macromolecule metabolic process

9 of 703

0.71

0.62

7.74e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008853

Exodeoxyribonuclease III activity

4 of 4

2.6

3.41

9.18e-07

GO:0004519

Endonuclease activity

4 of 26

1.79

2.08

3.89e-05

GO:0140097

Catalytic activity, acting on DNA

6 of 83

1.46

1.92

3.23e-06

GO:0003905

Alkylbase DNA N-glycosylase activity

2 of 3

2.42

1.48

0.0027

GO:0008270

Zinc ion binding

4 of 60

1.42

1.34

0.00056

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:682

Base excision repair, and methylated-DNA-[protein]-cysteine S-methyltransferase activity

7 of 13

2.33

5.86

1.51e-12

CL:684

AP endonuclease 1, and DNA glycosylase

4 of 7

2.36

3.15

1.63e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

woc03410

Base excision repair

5 of 15

2.12

3.65

4.34e-08

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03372

Endonuclease/Exonuclease/phosphatase family

3 of 7

2.23

1.74

0.00076

PF02805

Metal binding domain of Ada

2 of 2

2.6

1.18

0.0097

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036691

Endonuclease/exonuclease/phosphatase superfamily

4 of 8

2.3

2.66

1.35e-05

IPR037493

Exodeoxyribonuclease III-like

3 of 3

2.6

2.19

0.00016

IPR004808

AP endonuclease 1

3 of 3

2.6

2.19

0.00016

IPR005135

Endonuclease/exonuclease/phosphatase

3 of 7

2.23

1.84

0.00049

IPR035451

Ada-like domain superfamily

2 of 2

2.6

1.17

0.0100

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00342

Helix_turn_helix, arabinose operon control protein

2 of 2

2.6

1.41

0.0038

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