Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SCM55506.1Iron-sulfur flavoprotein AF_1519; Redox-active protein probably involved in electron transport. Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Note=Binds 1 FMN per subunit; Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 1 [4Fe-4S] cluster.; sp|O28753|ISF2_ARCFU;evalue=4e-079; PctID=74.35; score=293. (193 aa)    
Predicted Functional Partners:
fae-hps
Bifunctional enzyme Fae/Hps {ECO:0000255|HAMAP-Rule:MF_01268}; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the N-terminal section; belongs to the formaldehyde- activating enzyme family.
       0.802
SCM57444.1
Putative protein MJ0730; sp|Q58140|Y730_METJA;evalue=2e-043; PctID=49.73; score=174.
 
    0.778
SCM55510.1
Putative protein {ECO:0000313|EMBL:ADL57668,1}; tr|D9PTX0|D9PTX0_METTM;evalue=1e-023; PctID=61.46; score=114.
       0.766
wzx
Polysaccharide biosynthesis protein; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR); Hypothetical protein.
       0.611
aroA
2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase {ECO:0000255|HAMAP-Rule:MF_00960}; Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7- dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids.
 
  
 0.517
SCM56374.1
Putative protein MJ0480; sp|Q57904|Y480_METJA;evalue=1e-013; PctID=33.61; score=76.3.
   
    0.500
hisB
Imidazoleglycerol-phosphate dehydratase catalyzes the dehydration of imidazole glycerol phosphate to imidazole acetol phosphate, the sixth step of histidine biosynthesis in plants and microorganisms where the histidine is synthesized de novo. There is an internal repeat in the protein domain that is related by pseudo-dyad symmetry, perhaps as a result of an ancient gene duplication; Hypothetical protein.
  
    0.484
trpB2
Tryptophan synthase beta chain 2; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
       0.437
SCM55500.1
Hypothetical protein.
     
 0.434
SCM55502.1
Putative transporter protein {ECO:0000313|EMBL:ADL57664,1}; tr|D9PYW9|D9PYW9_METTM;evalue=9e-047; PctID=46.88; score=192.
       0.429
Your Current Organism:
Methanothermobacter wolfeii
NCBI taxonomy Id: 145261
Other names: ATCC 43096, DSM 2970, JCM 14652, M. wolfeii, Methanobacterium wolfei, Methanobacterium wolfeii, Methanothermobacter wolfei, NBRC 100332, OCM 154
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