Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SCM55755.1 | SCM55762.1 | MWSIV6_0138 | MWSIV6_0142 | Hypothetical Protein. | Protein archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | 0.686 |
| SCM55755.1 | mtiP | MWSIV6_0138 | MWSIV6_0140 | Hypothetical Protein. | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.846 |
| SCM55755.1 | rtcB | MWSIV6_0138 | MWSIV6_0141 | Hypothetical Protein. | tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. Binds 2 manganese ions per subunit. steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RtcB reacts with GTP to form a covalent RtcB-histidine-GMP intermediate with re [...] | 0.806 |
| SCM55755.1 | wrbA | MWSIV6_0138 | MWSIV6_0139 | Hypothetical Protein. | Multimeric flavodoxin WrbA. | 0.866 |
| SCM55762.1 | SCM55755.1 | MWSIV6_0142 | MWSIV6_0138 | Protein archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Hypothetical Protein. | 0.686 |
| SCM55762.1 | mtiP | MWSIV6_0142 | MWSIV6_0140 | Protein archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.763 |
| SCM55762.1 | rtcB | MWSIV6_0142 | MWSIV6_0141 | Protein archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | tRNA-splicing ligase that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs. Binds 2 manganese ions per subunit. steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RtcB reacts with GTP to form a covalent RtcB-histidine-GMP intermediate with re [...] | 0.997 |
| SCM55762.1 | wrbA | MWSIV6_0142 | MWSIV6_0139 | Protein archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently. | Multimeric flavodoxin WrbA. | 0.680 |
| SCM56237.1 | fucA | MWSIV6_0403 | MWSIV6_1786 | Putative methylthioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_01678}; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde. (S)-lactaldehyde. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit; lactaldehyde and glycerone phosphate from L-fucose: step 3/3. subfamily; sp|P44777|FUCA_HAEIN;evalue=5e-024; PctID=36.61; score=110. | 0.801 |
| SCM56237.1 | hpt | MWSIV6_0403 | MWSIV6_1709 | Putative methylthioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_01678}; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. | Hypoxanthine/guanine phosphoribosyltransferase {ECO:0000255|HAMAP-Rule:MF_01467}; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.652 |
| SCM56237.1 | mtiP | MWSIV6_0403 | MWSIV6_0140 | Putative methylthioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_01678}; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.974 |
| dadD | mtiP | MWSIV6_0045 | MWSIV6_0140 | 5'-deoxyadenosine deaminase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'- [...] | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.983 |
| dadD | upp | MWSIV6_0045 | MWSIV6_1506 | 5'-deoxyadenosine deaminase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'- [...] | Uracil phosphoribosyltransferase {ECO:0000255|HAMAP-Rule:MF_01218}; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.447 |
| fucA | SCM56237.1 | MWSIV6_1786 | MWSIV6_0403 | Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde. (S)-lactaldehyde. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit; lactaldehyde and glycerone phosphate from L-fucose: step 3/3. subfamily; sp|P44777|FUCA_HAEIN;evalue=5e-024; PctID=36.61; score=110. | Putative methylthioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_01678}; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.801 |
| fucA | hpt | MWSIV6_1786 | MWSIV6_1709 | Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde. (S)-lactaldehyde. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit; lactaldehyde and glycerone phosphate from L-fucose: step 3/3. subfamily; sp|P44777|FUCA_HAEIN;evalue=5e-024; PctID=36.61; score=110. | Hypoxanthine/guanine phosphoribosyltransferase {ECO:0000255|HAMAP-Rule:MF_01467}; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.637 |
| fucA | mtiP | MWSIV6_1786 | MWSIV6_0140 | Catalyzes the cleavage of L-fuculose 1-phosphate to glycerone phosphate and L-lactaldehyde. (S)-lactaldehyde. Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit; lactaldehyde and glycerone phosphate from L-fucose: step 3/3. subfamily; sp|P44777|FUCA_HAEIN;evalue=5e-024; PctID=36.61; score=110. | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.706 |
| guaAB | hpt | MWSIV6_1087 | MWSIV6_1709 | GMP synthase [glutamine-hydrolyzing] subunit B; Catalyzes the synthesis of GMP from XMP. | Hypoxanthine/guanine phosphoribosyltransferase {ECO:0000255|HAMAP-Rule:MF_01467}; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.989 |
| guaAB | mtiP | MWSIV6_1087 | MWSIV6_0140 | GMP synthase [glutamine-hydrolyzing] subunit B; Catalyzes the synthesis of GMP from XMP. | S-methyl-5'-thioinosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. | 0.721 |
| guaAB | upp | MWSIV6_1087 | MWSIV6_1506 | GMP synthase [glutamine-hydrolyzing] subunit B; Catalyzes the synthesis of GMP from XMP. | Uracil phosphoribosyltransferase {ECO:0000255|HAMAP-Rule:MF_01218}; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.770 |
| hpt | SCM56237.1 | MWSIV6_1709 | MWSIV6_0403 | Hypoxanthine/guanine phosphoribosyltransferase {ECO:0000255|HAMAP-Rule:MF_01467}; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Putative methylthioribose-1-phosphate isomerase {ECO:0000255|HAMAP-Rule:MF_01678}; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. | 0.652 |
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